Isolation Of Antimigratory Chemical Constituents From Curcuma Caesia, Curcuma Aeruginosa Rhizomes And Dioscorea Bulbifera Tubers Using Human Breast Cancer Cell Lines

Curcuma caesia, Curcuma aeruginosa and Dioscorea bulbifera are used traditionally for the treatment of human ailments including cancer. The present study was carried out to search for antimigratory compounds from C. caesia, C. aeruginosa rhizomes and D. bulbifera tubers using breast cancer cell l...

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Main Author:	Al-Amin, Md
Format:	Thesis
Language:	English
Published:	2021
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/51998/1/MD%20AL-AMIN%20-%20TESIS.pdf
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id	my-usm-ep.51998
record_format	uketd_dc
spelling	my-usm-ep.519982022-03-22T07:27:15Z Isolation Of Antimigratory Chemical Constituents From Curcuma Caesia, Curcuma Aeruginosa Rhizomes And Dioscorea Bulbifera Tubers Using Human Breast Cancer Cell Lines 2021-04 Al-Amin, Md RS1-441 Pharmacy and materia medica Curcuma caesia, Curcuma aeruginosa and Dioscorea bulbifera are used traditionally for the treatment of human ailments including cancer. The present study was carried out to search for antimigratory compounds from C. caesia, C. aeruginosa rhizomes and D. bulbifera tubers using breast cancer cell lines. The chemical constituents from C. caesia and C. aeruginosa rhizomes have been isolated through fractionation. The extracts of C. caesia and C. aeruginosa rhizomes showed concentration-dependent inhibition of MCF-7 and MDA-MB-231 cells. Further study showed that hexane and chloroform fractions of C. caesia rhizomes and chloroform fraction of C. aeruginosa rhizomes are the bioactive fractions that significantly inhibit the viability of breast cancer cells. The chromatographic separation afforded germacrone (1), zerumbone (2), furanodienone (3), curzerenone (4), curcumenol (5), zederone (6), curcumenone (7) and dehydrocurdione (8) from hexane fraction and curcuminol G (9), curcuzederone (10), (1S, 10S), (4S,5S)-germacrone-1(10), 4- diepoxide (11), wenyujinin B (12), alismoxide (13), aerugidiol (14), zedoarolide B (15), zedoalactone B (16) zedoarondiol (17) and isozedoarondiol (18) from chloroform fraction of C. caesia rhizomes. The chromatographic separation afforded germacrone (1), furanodienone (3), curzerenone (4), curcumenol (5) and zederone (6) from chloroform fraction of C. aeruginosa. Cell viability assay of these isolated compounds further revealed that compounds 1-4 and 10, and compounds 1, 3 and 4 are the bioactive compounds of C. caesia and C. aeruginosa, respectively. 2021-04 Thesis http://eprints.usm.my/51998/ http://eprints.usm.my/51998/1/MD%20AL-AMIN%20-%20TESIS.pdf application/pdf en public masters Perpustakaan Hamzah Sendut Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Al-Amin, Md Isolation Of Antimigratory Chemical Constituents From Curcuma Caesia, Curcuma Aeruginosa Rhizomes And Dioscorea Bulbifera Tubers Using Human Breast Cancer Cell Lines
description	Curcuma caesia, Curcuma aeruginosa and Dioscorea bulbifera are used traditionally for the treatment of human ailments including cancer. The present study was carried out to search for antimigratory compounds from C. caesia, C. aeruginosa rhizomes and D. bulbifera tubers using breast cancer cell lines. The chemical constituents from C. caesia and C. aeruginosa rhizomes have been isolated through fractionation. The extracts of C. caesia and C. aeruginosa rhizomes showed concentration-dependent inhibition of MCF-7 and MDA-MB-231 cells. Further study showed that hexane and chloroform fractions of C. caesia rhizomes and chloroform fraction of C. aeruginosa rhizomes are the bioactive fractions that significantly inhibit the viability of breast cancer cells. The chromatographic separation afforded germacrone (1), zerumbone (2), furanodienone (3), curzerenone (4), curcumenol (5), zederone (6), curcumenone (7) and dehydrocurdione (8) from hexane fraction and curcuminol G (9), curcuzederone (10), (1S, 10S), (4S,5S)-germacrone-1(10), 4- diepoxide (11), wenyujinin B (12), alismoxide (13), aerugidiol (14), zedoarolide B (15), zedoalactone B (16) zedoarondiol (17) and isozedoarondiol (18) from chloroform fraction of C. caesia rhizomes. The chromatographic separation afforded germacrone (1), furanodienone (3), curzerenone (4), curcumenol (5) and zederone (6) from chloroform fraction of C. aeruginosa. Cell viability assay of these isolated compounds further revealed that compounds 1-4 and 10, and compounds 1, 3 and 4 are the bioactive compounds of C. caesia and C. aeruginosa, respectively.
format	Thesis
qualification_level	Master's degree
author	Al-Amin, Md
author_facet	Al-Amin, Md
author_sort	Al-Amin, Md
title	Isolation Of Antimigratory Chemical Constituents From Curcuma Caesia, Curcuma Aeruginosa Rhizomes And Dioscorea Bulbifera Tubers Using Human Breast Cancer Cell Lines
title_short	Isolation Of Antimigratory Chemical Constituents From Curcuma Caesia, Curcuma Aeruginosa Rhizomes And Dioscorea Bulbifera Tubers Using Human Breast Cancer Cell Lines
title_full	Isolation Of Antimigratory Chemical Constituents From Curcuma Caesia, Curcuma Aeruginosa Rhizomes And Dioscorea Bulbifera Tubers Using Human Breast Cancer Cell Lines
title_fullStr	Isolation Of Antimigratory Chemical Constituents From Curcuma Caesia, Curcuma Aeruginosa Rhizomes And Dioscorea Bulbifera Tubers Using Human Breast Cancer Cell Lines
title_full_unstemmed	Isolation Of Antimigratory Chemical Constituents From Curcuma Caesia, Curcuma Aeruginosa Rhizomes And Dioscorea Bulbifera Tubers Using Human Breast Cancer Cell Lines
title_sort	isolation of antimigratory chemical constituents from curcuma caesia, curcuma aeruginosa rhizomes and dioscorea bulbifera tubers using human breast cancer cell lines
granting_institution	Perpustakaan Hamzah Sendut
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2021
url	http://eprints.usm.my/51998/1/MD%20AL-AMIN%20-%20TESIS.pdf
_version_	1747822123457445888

Isolation Of Antimigratory Chemical Constituents From Curcuma Caesia, Curcuma Aeruginosa Rhizomes And Dioscorea Bulbifera Tubers Using Human Breast Cancer Cell Lines

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