Pharmacokinetic And Pharmacodynamic Modeling Of Mitragynine In PainTolerance

Mitragyna speciosa, also known as ‘Ketum’or ‘Biak-biak’ in Malaysia and Kratom in Thailand, is a native plant to Southeast Asia. It has a long history of folk medicine use in Southeast Asia and recently has gained popularity in Western countries. Mitragynine (MG) is the principal alkaloid found in t...

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Main Author:	Ramachandram, Dinesh Sangarran
Format:	Thesis
Language:	English
Published:	2020
Subjects:	RM300-666 Drugs and their actions
Online Access:	http://eprints.usm.my/52605/1/Pages%20from%20DINESH%20SANGARRAN%20AL%20RAMACHANDRAM%20-%20TESIS.pdf
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spelling	my-usm-ep.526052022-05-26T07:11:37Z Pharmacokinetic And Pharmacodynamic Modeling Of Mitragynine In PainTolerance 2020-11 Ramachandram, Dinesh Sangarran RM300-666 Drugs and their actions Mitragyna speciosa, also known as ‘Ketum’or ‘Biak-biak’ in Malaysia and Kratom in Thailand, is a native plant to Southeast Asia. It has a long history of folk medicine use in Southeast Asia and recently has gained popularity in Western countries. Mitragynine (MG) is the principal alkaloid found in the leaves of Mitragyna speciosa and has been reported to be responsible for the plant’s therapeutic actions. Pain relief is among many self-reported beneficial kratom effects. However, there have not been any controlled clinical studies reported on the analgesic property of Ketum employed a standardized formulation. The objective of this study is to evaluate the PKPD of mitragynine in human subjects. In view of this, work was undertaken in Universiti Sains Malaysia to scientifically assess the pain relief effects of Ketum decoction in a randomized, double-blind, placebo- controlled study. Ketum and placebo decoctions were prepared and standardized as a formulation to be administered to the subjects in the clinical study. 2020-11 Thesis http://eprints.usm.my/52605/ http://eprints.usm.my/52605/1/Pages%20from%20DINESH%20SANGARRAN%20AL%20RAMACHANDRAM%20-%20TESIS.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Penyelidikan Dadah Dan Ubat-Ubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RM300-666 Drugs and their actions
spellingShingle	RM300-666 Drugs and their actions Ramachandram, Dinesh Sangarran Pharmacokinetic And Pharmacodynamic Modeling Of Mitragynine In PainTolerance
description	Mitragyna speciosa, also known as ‘Ketum’or ‘Biak-biak’ in Malaysia and Kratom in Thailand, is a native plant to Southeast Asia. It has a long history of folk medicine use in Southeast Asia and recently has gained popularity in Western countries. Mitragynine (MG) is the principal alkaloid found in the leaves of Mitragyna speciosa and has been reported to be responsible for the plant’s therapeutic actions. Pain relief is among many self-reported beneficial kratom effects. However, there have not been any controlled clinical studies reported on the analgesic property of Ketum employed a standardized formulation. The objective of this study is to evaluate the PKPD of mitragynine in human subjects. In view of this, work was undertaken in Universiti Sains Malaysia to scientifically assess the pain relief effects of Ketum decoction in a randomized, double-blind, placebo- controlled study. Ketum and placebo decoctions were prepared and standardized as a formulation to be administered to the subjects in the clinical study.
format	Thesis
qualification_level	Master's degree
author	Ramachandram, Dinesh Sangarran
author_facet	Ramachandram, Dinesh Sangarran
author_sort	Ramachandram, Dinesh Sangarran
title	Pharmacokinetic And Pharmacodynamic Modeling Of Mitragynine In PainTolerance
title_short	Pharmacokinetic And Pharmacodynamic Modeling Of Mitragynine In PainTolerance
title_full	Pharmacokinetic And Pharmacodynamic Modeling Of Mitragynine In PainTolerance
title_fullStr	Pharmacokinetic And Pharmacodynamic Modeling Of Mitragynine In PainTolerance
title_full_unstemmed	Pharmacokinetic And Pharmacodynamic Modeling Of Mitragynine In PainTolerance
title_sort	pharmacokinetic and pharmacodynamic modeling of mitragynine in paintolerance
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Penyelidikan Dadah Dan Ubat-Ubatan
publishDate	2020
url	http://eprints.usm.my/52605/1/Pages%20from%20DINESH%20SANGARRAN%20AL%20RAMACHANDRAM%20-%20TESIS.pdf
_version_	1747822198853206016

Pharmacokinetic And Pharmacodynamic Modeling Of Mitragynine In PainTolerance

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