Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity

The goal of this thesis is to design new FA analogues with higher selectivity to bind with FRα. Fifty FA-analogues with variant heterocyclic rings were designed and studied for their interaction with FRα. Docking results showed 20 out of the 50 FA-analogues showed higher binding affinity than methot...

Full description

Saved in:

Bibliographic Details
Main Author:	Althiabat, Mohammad Gasem Mohammad
Format:	Thesis
Language:	English
Published:	2020
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/53495/1/MOHAMMAD%20GASEM%20MOHAMMAD%20ALTHIABAT%20-%20TESIS.pdf%20cut.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.53495
record_format	uketd_dc
spelling	my-usm-ep.534952022-07-21T01:53:26Z Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity 2020-10 Althiabat, Mohammad Gasem Mohammad RS1-441 Pharmacy and materia medica The goal of this thesis is to design new FA analogues with higher selectivity to bind with FRα. Fifty FA-analogues with variant heterocyclic rings were designed and studied for their interaction with FRα. Docking results showed 20 out of the 50 FA-analogues showed higher binding affinity than methotrexate (MTX) and the parent folic acid (FA) towards FRα. 2020-10 Thesis http://eprints.usm.my/53495/ http://eprints.usm.my/53495/1/MOHAMMAD%20GASEM%20MOHAMMAD%20ALTHIABAT%20-%20TESIS.pdf%20cut.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Farmasi (School of Pharmacy)
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Althiabat, Mohammad Gasem Mohammad Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity
description	The goal of this thesis is to design new FA analogues with higher selectivity to bind with FRα. Fifty FA-analogues with variant heterocyclic rings were designed and studied for their interaction with FRα. Docking results showed 20 out of the 50 FA-analogues showed higher binding affinity than methotrexate (MTX) and the parent folic acid (FA) towards FRα.
format	Thesis
qualification_level	Master's degree
author	Althiabat, Mohammad Gasem Mohammad
author_facet	Althiabat, Mohammad Gasem Mohammad
author_sort	Althiabat, Mohammad Gasem Mohammad
title	Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity
title_short	Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity
title_full	Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity
title_fullStr	Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity
title_full_unstemmed	Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity
title_sort	rational drug design of new folic acid analogues with high binding affinity and anticancer activity
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Farmasi (School of Pharmacy)
publishDate	2020
url	http://eprints.usm.my/53495/1/MOHAMMAD%20GASEM%20MOHAMMAD%20ALTHIABAT%20-%20TESIS.pdf%20cut.pdf
_version_	1747822246905249792

Rational Drug Design Of New Folic Acid Analogues With High Binding Affinity And Anticancer Activity

Similar Items