Prevalence and determinants of Small Intestine Bacterial Overgrowth (SIBO) and carbohydrate intolerance in symptomatic Functional Bowel Disorder (FBD)
Symptomatic Functional Bowel Disorder (FBD) has been a quite common presentation to the healthcare personnel. These patients often have other conditions that co-exist, such as Small Intestinal Bacterial Overgrowth (SIBO) and carbohydrate intolerance. SIBO and carbohydrate intolerance tend to wors...
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| Main Author: | |
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| Format: | Thesis |
| Language: | English |
| Published: |
2020
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| Subjects: | |
| Online Access: | http://eprints.usm.my/56917/1/SUFIAN%20CHONG%20CHERN%20SIONG%20-%20e%2024.pdf |
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| Summary: | Symptomatic Functional Bowel Disorder (FBD) has been a quite common
presentation to the healthcare personnel. These patients often have other conditions that
co-exist, such as Small Intestinal Bacterial Overgrowth (SIBO) and carbohydrate
intolerance. SIBO and carbohydrate intolerance tend to worsen the symptoms of FBD.
With the hydrogen breath test readily available nowadays, we can easily diagnose SIBO
and carbohydrate intolerance. The test is rather simple and safe. This allow us to tackle
the issue of refractory FBDs and improving the symptoms of those who has FBDs. This retrospective cross-sectional study involved all subjects who were more
than 12 years old and had undergone hydrogen breath test at Hospital Universiti Sains
Malaysia (HUSM) Kubang Kerian from 1st January until 1st July 2019. The data were
obtained from the subject’s medical record. We analysed the prevalence of SIBO and
carbohydrate intolerance. We also analysed the associated factors using simple and
multiple logistic regression. A total of 104 subjects were analysed. Among the 104 subjects, females were
51.9% (n=54), and males were 48.1% (n=50). The mean age of all the participants was
49.76 years old. The prevalence of SIBO, fructose intolerance /malabsorption, and lactose
intolerance /malabsorption were 20%, 39% and 66% respectively. There were significant
association between age (p≤0.050) and diabetes mellitus (p<0.001) with SIBO. There
were no significant association factors found for the carbohydrate intolerance. It appears that lactose intolerance /malabsorption has higher prevalence in
FBD compared to fructose intolerance /malabsorption and SIBO in this study. Not many
significant associated factors for the three conditions that we studied were obtained. |
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