Comparison of the efficacy of intravenous oxycodone versus morphine on postoperative pain following orthopaedics surgery under general anaesthesia

Background Acute, severe postoperative pain is common following orthopaedics surgery and morphine is the commonest used intravenous opioid. The introduction of intravenous (IV) oxycodone has replaced morphine as the first choice of opioid used in postoperative pain management in some countries. T...

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Main Author:	Sim, Chua Boon
Format:	Thesis
Language:	English
Published:	2020
Subjects:	RD701-811 Orthopedic surgery
Online Access:	http://eprints.usm.my/57285/1/DR%20CHUA%20BOON%20SIM-24%20pages.pdf
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spelling	my-usm-ep.572852023-03-14T09:14:09Z Comparison of the efficacy of intravenous oxycodone versus morphine on postoperative pain following orthopaedics surgery under general anaesthesia 2020 Sim, Chua Boon RD701-811 Orthopedic surgery Background Acute, severe postoperative pain is common following orthopaedics surgery and morphine is the commonest used intravenous opioid. The introduction of intravenous (IV) oxycodone has replaced morphine as the first choice of opioid used in postoperative pain management in some countries. The aim of this study is to assess the efficacy of IV oxycodone versus morphine on postoperative pain following orthopaedics surgery under general anaesthesia. Methods Fifty-eight American Society of Anesthesiologists (ASA) physical status I–II patients were randomly assigned to receive either 0.08 mg/kg IV oxycodone (Group O, n = 29) or 0.08 mg/kg morphine (Group M, n = 29) at the starting of skin closure. Postoperative pain was evaluated using a visual analogue scale (VAS) from at 0 min, hourly till 6th hour postoperatively. The time to first rescue analgesia, requirement of the first and second rescue analgesia and adverse effects were assessed. Results Postoperative pain score did not differ significantly in Group O and Group M from 0 min, hourly till 6th hour postoperatively (P > 0.950). There were no significant differences in the time to first rescue analgesia (P = 0.721), requirement of first (P = 0.594) and second rescue analgesia (P = 0.517) and adverse effects in both groups. Conclusion Intravenous oxycodone is equipotent to morphine in treating acute postoperative pain following orthopaedics surgery, and it is not associated with an increased risk of opioid related adverse events. 2020 Thesis http://eprints.usm.my/57285/ http://eprints.usm.my/57285/1/DR%20CHUA%20BOON%20SIM-24%20pages.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RD701-811 Orthopedic surgery
spellingShingle	RD701-811 Orthopedic surgery Sim, Chua Boon Comparison of the efficacy of intravenous oxycodone versus morphine on postoperative pain following orthopaedics surgery under general anaesthesia
description	Background Acute, severe postoperative pain is common following orthopaedics surgery and morphine is the commonest used intravenous opioid. The introduction of intravenous (IV) oxycodone has replaced morphine as the first choice of opioid used in postoperative pain management in some countries. The aim of this study is to assess the efficacy of IV oxycodone versus morphine on postoperative pain following orthopaedics surgery under general anaesthesia. Methods Fifty-eight American Society of Anesthesiologists (ASA) physical status I–II patients were randomly assigned to receive either 0.08 mg/kg IV oxycodone (Group O, n = 29) or 0.08 mg/kg morphine (Group M, n = 29) at the starting of skin closure. Postoperative pain was evaluated using a visual analogue scale (VAS) from at 0 min, hourly till 6th hour postoperatively. The time to first rescue analgesia, requirement of the first and second rescue analgesia and adverse effects were assessed. Results Postoperative pain score did not differ significantly in Group O and Group M from 0 min, hourly till 6th hour postoperatively (P > 0.950). There were no significant differences in the time to first rescue analgesia (P = 0.721), requirement of first (P = 0.594) and second rescue analgesia (P = 0.517) and adverse effects in both groups. Conclusion Intravenous oxycodone is equipotent to morphine in treating acute postoperative pain following orthopaedics surgery, and it is not associated with an increased risk of opioid related adverse events.
format	Thesis
qualification_level	Master's degree
author	Sim, Chua Boon
author_facet	Sim, Chua Boon
author_sort	Sim, Chua Boon
title	Comparison of the efficacy of intravenous oxycodone versus morphine on postoperative pain following orthopaedics surgery under general anaesthesia
title_short	Comparison of the efficacy of intravenous oxycodone versus morphine on postoperative pain following orthopaedics surgery under general anaesthesia
title_full	Comparison of the efficacy of intravenous oxycodone versus morphine on postoperative pain following orthopaedics surgery under general anaesthesia
title_fullStr	Comparison of the efficacy of intravenous oxycodone versus morphine on postoperative pain following orthopaedics surgery under general anaesthesia
title_full_unstemmed	Comparison of the efficacy of intravenous oxycodone versus morphine on postoperative pain following orthopaedics surgery under general anaesthesia
title_sort	comparison of the efficacy of intravenous oxycodone versus morphine on postoperative pain following orthopaedics surgery under general anaesthesia
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2020
url	http://eprints.usm.my/57285/1/DR%20CHUA%20BOON%20SIM-24%20pages.pdf
_version_	1776101196355862528

Comparison of the efficacy of intravenous oxycodone versus morphine on postoperative pain following orthopaedics surgery under general anaesthesia

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