Rational Design And Synthesis Of Peptide Inhibitors Of Ns2b/Ns3 Protease As Therapeutic Agents For Dengue Virus Type 2

Rational Design And Synthesis Of Peptide Inhibitors Of Ns2b/Ns3 Protease As Therapeutic Agents For Dengue Virus Type 2

The main objectives of this study are to design potent and selective peptide inhibitors by studying the interactions between the designed peptides and the NS2B/NS3 dengue protease using two independent docking programs (MOE and AutoDock4.2), thus, to evaluate the quantitative and qualitative docking...

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Main Author: Abdalrazaq, Nadeem Abdalsatar
Format: Thesis
Language:English
Published: 2021
Subjects:
RS1-441 Pharmacy and materia medica
Online Access:http://eprints.usm.my/59307/1/NADEEM%20ABDALSATAR%20ABDALRAZAQ%20ABDALRAZAQ%20-%20TESIS%20cut.pdf
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spelling my-usm-ep.593072023-09-01T02:10:49Z Rational Design And Synthesis Of Peptide Inhibitors Of Ns2b/Ns3 Protease As Therapeutic Agents For Dengue Virus Type 2 2021-10 Abdalrazaq, Nadeem Abdalsatar RS1-441 Pharmacy and materia medica The main objectives of this study are to design potent and selective peptide inhibitors by studying the interactions between the designed peptides and the NS2B/NS3 dengue protease using two independent docking programs (MOE and AutoDock4.2), thus, to evaluate the quantitative and qualitative docking results from both programs. The other objectives are to synthesize and characterize the potential peptides by using Fmoc Solid Phase Peptide Synthesis (SPPS) technique, to perform NS2B/NS3 dengue protease expression and purification, and finally to investigate the biological evaluation of the selected peptides using in vitro NS2B/NS3 dengue protease inhibition assay. 2021-10 Thesis http://eprints.usm.my/59307/ http://eprints.usm.my/59307/1/NADEEM%20ABDALSATAR%20ABDALRAZAQ%20ABDALRAZAQ%20-%20TESIS%20cut.pdf application/pdf en public phd doctoral Universiti Sains Malaysia Pusat Pengajian Sains Farmasi (School of Pharmacy)
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Abdalrazaq, Nadeem Abdalsatar
Rational Design And Synthesis Of Peptide Inhibitors Of Ns2b/Ns3 Protease As Therapeutic Agents For Dengue Virus Type 2
description The main objectives of this study are to design potent and selective peptide inhibitors by studying the interactions between the designed peptides and the NS2B/NS3 dengue protease using two independent docking programs (MOE and AutoDock4.2), thus, to evaluate the quantitative and qualitative docking results from both programs. The other objectives are to synthesize and characterize the potential peptides by using Fmoc Solid Phase Peptide Synthesis (SPPS) technique, to perform NS2B/NS3 dengue protease expression and purification, and finally to investigate the biological evaluation of the selected peptides using in vitro NS2B/NS3 dengue protease inhibition assay.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Abdalrazaq, Nadeem Abdalsatar
author_facet Abdalrazaq, Nadeem Abdalsatar
author_sort Abdalrazaq, Nadeem Abdalsatar
title Rational Design And Synthesis Of Peptide Inhibitors Of Ns2b/Ns3 Protease As Therapeutic Agents For Dengue Virus Type 2
title_short Rational Design And Synthesis Of Peptide Inhibitors Of Ns2b/Ns3 Protease As Therapeutic Agents For Dengue Virus Type 2
title_full Rational Design And Synthesis Of Peptide Inhibitors Of Ns2b/Ns3 Protease As Therapeutic Agents For Dengue Virus Type 2
title_fullStr Rational Design And Synthesis Of Peptide Inhibitors Of Ns2b/Ns3 Protease As Therapeutic Agents For Dengue Virus Type 2
title_full_unstemmed Rational Design And Synthesis Of Peptide Inhibitors Of Ns2b/Ns3 Protease As Therapeutic Agents For Dengue Virus Type 2
title_sort rational design and synthesis of peptide inhibitors of ns2b/ns3 protease as therapeutic agents for dengue virus type 2
granting_institution Universiti Sains Malaysia
granting_department Pusat Pengajian Sains Farmasi (School of Pharmacy)
publishDate 2021
url http://eprints.usm.my/59307/1/NADEEM%20ABDALSATAR%20ABDALRAZAQ%20ABDALRAZAQ%20-%20TESIS%20cut.pdf
_version_ 1776101284485529600

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