Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application
A study was conducted to formulate a semi-solid SEDDS with enhanced bioavailability using Gelucire® 44/14 as the self-emulsifying agent and a tocotrienols mixture (EVNol™ 50%) as the liquid model drug. A series of formulations with different proportions of tocotrienol extract and Gelucire® 44/14 wer...
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my-usm-ep.593212023-09-04T01:19:49Z Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application 2022-02 Abu Bakar, Syazana RS1-441 Pharmacy and materia medica A study was conducted to formulate a semi-solid SEDDS with enhanced bioavailability using Gelucire® 44/14 as the self-emulsifying agent and a tocotrienols mixture (EVNol™ 50%) as the liquid model drug. A series of formulations with different proportions of tocotrienol extract and Gelucire® 44/14 were prepared and evaluated. Finally, a formulation with 1:1 ratio of tocotrienols to Gelucire® 44/14 with the addition of 2.5% of propylene glycol was found most suitable to obtain a semi-solid SEDDS with satisfactory self-emulsifying properties. From a series of in vitro studies, the formulation was able to self-emulsify under gentle agitation and formed an oil in water emulsion within 3 minutes upon contact with the dissolution media. The emulsion formed was stable, with the emulsion particle size distribution achieving nano-range. Subsequently, 2022-02 Thesis http://eprints.usm.my/59321/ http://eprints.usm.my/59321/1/24%20Pages%20from%20SYAZANA%20BINTI%20ABU%20BAKAR%20-%20TESIS.pdf application/pdf en public phd doctoral Perpustakaan Hamzah Sendut Pusat Pengajian Sains Farmasi |
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RS1-441 Pharmacy and materia medica |
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RS1-441 Pharmacy and materia medica Abu Bakar, Syazana Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application |
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A study was conducted to formulate a semi-solid SEDDS with enhanced bioavailability using Gelucire® 44/14 as the self-emulsifying agent and a tocotrienols mixture (EVNol™ 50%) as the liquid model drug. A series of formulations with different proportions of tocotrienol extract and Gelucire® 44/14 were prepared and evaluated. Finally, a formulation with 1:1 ratio of tocotrienols to Gelucire® 44/14 with the addition of 2.5% of propylene glycol was found most suitable to obtain a semi-solid SEDDS with satisfactory self-emulsifying properties. From a series of in vitro studies, the formulation was able to self-emulsify under gentle agitation and formed an oil in water emulsion within 3 minutes upon contact with the dissolution media. The emulsion formed was stable, with the emulsion particle size distribution achieving nano-range. Subsequently, |
format |
Thesis |
qualification_name |
Doctor of Philosophy (PhD.) |
qualification_level |
Doctorate |
author |
Abu Bakar, Syazana |
author_facet |
Abu Bakar, Syazana |
author_sort |
Abu Bakar, Syazana |
title |
Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application |
title_short |
Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application |
title_full |
Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application |
title_fullStr |
Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application |
title_full_unstemmed |
Development Of Semi-Solid Self-Emulsifying Drug Delivery System (Sedds) Using Liquid Model Drug For Oral Drug Delivery Application |
title_sort |
development of semi-solid self-emulsifying drug delivery system (sedds) using liquid model drug for oral drug delivery application |
granting_institution |
Perpustakaan Hamzah Sendut |
granting_department |
Pusat Pengajian Sains Farmasi |
publishDate |
2022 |
url |
http://eprints.usm.my/59321/1/24%20Pages%20from%20SYAZANA%20BINTI%20ABU%20BAKAR%20-%20TESIS.pdf |
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1776101287804272640 |