Synergistic Activity Of Ceftriaxone And Polyalthia Longifolia Leaves Extract Against Methicillin Resistant Staphylococcus Aureus (Mrsa)

Methicillin‐resistant Staphylococcus aureus (MRSA) infection has become one of the most significant pathogenic bacterial infection health issues in developing countries. Furthermore, the most important mecA gene that is encodes a novel penicillin-binding protein PBP2a contributes to the methicillin...

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Main Author:	Valiappan, Ranjutha
Format:	Thesis
Language:	English
Published:	2021
Subjects:	R5-920 Medicine (General)
Online Access:	http://eprints.usm.my/59556/1/24%20Pages%20from%20RANJUTHA%20AP%20VALIAPPAN.pdf
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id	my-usm-ep.59556
record_format	uketd_dc
spelling	my-usm-ep.595562023-10-26T02:59:24Z Synergistic Activity Of Ceftriaxone And Polyalthia Longifolia Leaves Extract Against Methicillin Resistant Staphylococcus Aureus (Mrsa) 2021-09 Valiappan, Ranjutha R5-920 Medicine (General) Methicillin‐resistant Staphylococcus aureus (MRSA) infection has become one of the most significant pathogenic bacterial infection health issues in developing countries. Furthermore, the most important mecA gene that is encodes a novel penicillin-binding protein PBP2a contributes to the methicillin resistance in MRSA strains. Therefore, new alternative strategies are needed to address this issue by developing a new antimicrobial agent, modifying the existing antibiotic activity with a combination of plant extracts as resistance modifying agents, or using the plant extract combined with existing antibiotics against resistant bacteria. Consequently, the current study was conducted to evaluate the antibiotic modifying activity and synergistic effects of methanol extract Polyalthia longifolia (Sonn.) Thwaites (Annonaceae family) against MRSA in combination with ceftriaxone. The antibiotic modifying activity and synergistic effects of P. longifolia leaf methanol extract (PLLME) were evaluated in this study by disc diffusion method, broth microdilution method, checkerboard microdilution method, and detection of the mecA gene suppression by multiplex Polymerase chain reaction (PCR). 2021-09 Thesis http://eprints.usm.my/59556/ http://eprints.usm.my/59556/1/24%20Pages%20from%20RANJUTHA%20AP%20VALIAPPAN.pdf application/pdf en public masters Universiti Sains Malaysia Institut Penyelidikan Perubatan Molekul (Institute for Research in Molecular Medicine INFORMM)
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R5-920 Medicine (General)
spellingShingle	R5-920 Medicine (General) Valiappan, Ranjutha Synergistic Activity Of Ceftriaxone And Polyalthia Longifolia Leaves Extract Against Methicillin Resistant Staphylococcus Aureus (Mrsa)
description	Methicillin‐resistant Staphylococcus aureus (MRSA) infection has become one of the most significant pathogenic bacterial infection health issues in developing countries. Furthermore, the most important mecA gene that is encodes a novel penicillin-binding protein PBP2a contributes to the methicillin resistance in MRSA strains. Therefore, new alternative strategies are needed to address this issue by developing a new antimicrobial agent, modifying the existing antibiotic activity with a combination of plant extracts as resistance modifying agents, or using the plant extract combined with existing antibiotics against resistant bacteria. Consequently, the current study was conducted to evaluate the antibiotic modifying activity and synergistic effects of methanol extract Polyalthia longifolia (Sonn.) Thwaites (Annonaceae family) against MRSA in combination with ceftriaxone. The antibiotic modifying activity and synergistic effects of P. longifolia leaf methanol extract (PLLME) were evaluated in this study by disc diffusion method, broth microdilution method, checkerboard microdilution method, and detection of the mecA gene suppression by multiplex Polymerase chain reaction (PCR).
format	Thesis
qualification_level	Master's degree
author	Valiappan, Ranjutha
author_facet	Valiappan, Ranjutha
author_sort	Valiappan, Ranjutha
title	Synergistic Activity Of Ceftriaxone And Polyalthia Longifolia Leaves Extract Against Methicillin Resistant Staphylococcus Aureus (Mrsa)
title_short	Synergistic Activity Of Ceftriaxone And Polyalthia Longifolia Leaves Extract Against Methicillin Resistant Staphylococcus Aureus (Mrsa)
title_full	Synergistic Activity Of Ceftriaxone And Polyalthia Longifolia Leaves Extract Against Methicillin Resistant Staphylococcus Aureus (Mrsa)
title_fullStr	Synergistic Activity Of Ceftriaxone And Polyalthia Longifolia Leaves Extract Against Methicillin Resistant Staphylococcus Aureus (Mrsa)
title_full_unstemmed	Synergistic Activity Of Ceftriaxone And Polyalthia Longifolia Leaves Extract Against Methicillin Resistant Staphylococcus Aureus (Mrsa)
title_sort	synergistic activity of ceftriaxone and polyalthia longifolia leaves extract against methicillin resistant staphylococcus aureus (mrsa)
granting_institution	Universiti Sains Malaysia
granting_department	Institut Penyelidikan Perubatan Molekul (Institute for Research in Molecular Medicine INFORMM)
publishDate	2021
url	http://eprints.usm.my/59556/1/24%20Pages%20from%20RANJUTHA%20AP%20VALIAPPAN.pdf
_version_	1783729577485402112

Synergistic Activity Of Ceftriaxone And Polyalthia Longifolia Leaves Extract Against Methicillin Resistant Staphylococcus Aureus (Mrsa)

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