Perinatal, maternal and antenatal associated factors for autism: a case control study

Autism disorders are a group of neurodevelopmental disorders which characterized into three main domains which are social interaction impairment, communication delay and repetitive or stereotypic behavior. Many studies had suggested that the risk factors for autism derive from three big factors nam...

Full description

Saved in:

Bibliographic Details
Main Author:	Abdullah, Mohammad Nasir
Format:	Thesis
Language:	English
Published:	2011
Subjects:	RG551-591 Pregnancy
Online Access:	http://eprints.usm.my/59584/1/MOHAMMAD%20NASIR%20BIN%20ABDULLAH%20-%20e.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.59584
record_format	uketd_dc
spelling	my-usm-ep.595842023-11-14T07:42:53Z Perinatal, maternal and antenatal associated factors for autism: a case control study 2011 Abdullah, Mohammad Nasir RG551-591 Pregnancy Autism disorders are a group of neurodevelopmental disorders which characterized into three main domains which are social interaction impairment, communication delay and repetitive or stereotypic behavior. Many studies had suggested that the risk factors for autism derive from three big factors namely environmental factors, genetic predisposition and vaccine induced. The aim of this study was to investigate the perinatal, maternal and antenatal associated factors on autistic disorder children at Hospital Pulau Pinang and Hospital Bukit Mertajam, Pulau Pinang. A case control study involving 312 cases and control was conducted using data retrieved from hospital records at Pulau Pinang hospital and Bukit Mertajam hospital from 2001 to 2008. The departments involved were Psychiatric, Obstetrics and Gynecology and Record and Management Department. All cases which met the inclusion and exclusion criteria were included in the study. Univariable and multivariable logistic regression were used to explore the prenatal/perinatal risk factors associated with autistic disorder children. There were seven risk factors contributed most to autistic disorder determination. The factors were maternal age [Adjusted OR: 1.41; 95% CI: (1.27, 1.57)], maternal smoking reported at first antenatal visit [Adjusted OR: 13.61; 95% CI: (1.87, 99.35)], birth asphyxia [Adjusted OR: 0.35; 95% CI: (0.11, 1.08)], psychiatric history [Adjusted OR: 54.94; 95% CI: (12.07, 250.04)], multiple gestation [Adjusted OR: 4.81; 95% CI: (1.86, 12.45)], parity for more than 4 [Adjusted OR: 0.11; 95% CI: (0.03, 0.47)], parity between 0 and 1 [Adjusted OR: 0.19; 95% CI: (0.07,0.55)], Chinese race compared to the Malay race [Adjusted OR: 10.11; 95% CI: (3.61, 28.30)] and Indian race compared to the Malay race [Adjusted OR: 5.14; 95% CI: (1.38, 19.16)]. The results suggested that autistic disorders were associated with perinatal, maternal and antenatal factors such as delivery, pregnancy and maternal characteristics. Universiti Sains Malaysia 2011 Thesis http://eprints.usm.my/59584/ http://eprints.usm.my/59584/1/MOHAMMAD%20NASIR%20BIN%20ABDULLAH%20-%20e.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RG551-591 Pregnancy
spellingShingle	RG551-591 Pregnancy Abdullah, Mohammad Nasir Perinatal, maternal and antenatal associated factors for autism: a case control study
description	Autism disorders are a group of neurodevelopmental disorders which characterized into three main domains which are social interaction impairment, communication delay and repetitive or stereotypic behavior. Many studies had suggested that the risk factors for autism derive from three big factors namely environmental factors, genetic predisposition and vaccine induced. The aim of this study was to investigate the perinatal, maternal and antenatal associated factors on autistic disorder children at Hospital Pulau Pinang and Hospital Bukit Mertajam, Pulau Pinang. A case control study involving 312 cases and control was conducted using data retrieved from hospital records at Pulau Pinang hospital and Bukit Mertajam hospital from 2001 to 2008. The departments involved were Psychiatric, Obstetrics and Gynecology and Record and Management Department. All cases which met the inclusion and exclusion criteria were included in the study. Univariable and multivariable logistic regression were used to explore the prenatal/perinatal risk factors associated with autistic disorder children. There were seven risk factors contributed most to autistic disorder determination. The factors were maternal age [Adjusted OR: 1.41; 95% CI: (1.27, 1.57)], maternal smoking reported at first antenatal visit [Adjusted OR: 13.61; 95% CI: (1.87, 99.35)], birth asphyxia [Adjusted OR: 0.35; 95% CI: (0.11, 1.08)], psychiatric history [Adjusted OR: 54.94; 95% CI: (12.07, 250.04)], multiple gestation [Adjusted OR: 4.81; 95% CI: (1.86, 12.45)], parity for more than 4 [Adjusted OR: 0.11; 95% CI: (0.03, 0.47)], parity between 0 and 1 [Adjusted OR: 0.19; 95% CI: (0.07,0.55)], Chinese race compared to the Malay race [Adjusted OR: 10.11; 95% CI: (3.61, 28.30)] and Indian race compared to the Malay race [Adjusted OR: 5.14; 95% CI: (1.38, 19.16)]. The results suggested that autistic disorders were associated with perinatal, maternal and antenatal factors such as delivery, pregnancy and maternal characteristics.
format	Thesis
qualification_level	Master's degree
author	Abdullah, Mohammad Nasir
author_facet	Abdullah, Mohammad Nasir
author_sort	Abdullah, Mohammad Nasir
title	Perinatal, maternal and antenatal associated factors for autism: a case control study
title_short	Perinatal, maternal and antenatal associated factors for autism: a case control study
title_full	Perinatal, maternal and antenatal associated factors for autism: a case control study
title_fullStr	Perinatal, maternal and antenatal associated factors for autism: a case control study
title_full_unstemmed	Perinatal, maternal and antenatal associated factors for autism: a case control study
title_sort	perinatal, maternal and antenatal associated factors for autism: a case control study
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2011
url	http://eprints.usm.my/59584/1/MOHAMMAD%20NASIR%20BIN%20ABDULLAH%20-%20e.pdf
_version_	1783729581993230336

Perinatal, maternal and antenatal associated factors for autism: a case control study

Similar Items