Development Of Electrospun Nanofibres Containing Ibuprofen Grafted Nanocrystalline Cellulose For Dermal Delivery

Development Of Electrospun Nanofibres Containing Ibuprofen Grafted Nanocrystalline Cellulose For Dermal Delivery

Nanomaterials offer various benefits in dermal drug delivery, including a large surface-to-volume ratio and enhanced drug disposition in the skin. Nanocrystalline cellulose (NCC) is a potential drug nanocarrier due to its abundant surface hydroxyl groups, making it suitable to be grafted with active...

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Main Author: Ahmed Al-Mashhadani, Abdulsalam Qahtan
Format: Thesis
Language:English
Published: 2022
Subjects:
RS1-441 Pharmacy and materia medica
Online Access:http://eprints.usm.my/59658/1/24%20Pages%20from%20ABDULSALAM%20QAHTAN%20AHMED%20AL%20MASHHADANI%20-%20TESIS.pdf
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spelling my-usm-ep.596582023-12-13T01:22:18Z Development Of Electrospun Nanofibres Containing Ibuprofen Grafted Nanocrystalline Cellulose For Dermal Delivery 2022-09 Ahmed Al-Mashhadani, Abdulsalam Qahtan RS1-441 Pharmacy and materia medica Nanomaterials offer various benefits in dermal drug delivery, including a large surface-to-volume ratio and enhanced drug disposition in the skin. Nanocrystalline cellulose (NCC) is a potential drug nanocarrier due to its abundant surface hydroxyl groups, making it suitable to be grafted with active pharmaceutical ingredients. However, dermal delivery of nanomaterials needs a proper platform to ensure a good distribution in the formulations. The objective of the thesis is to investigate the electrospun nanofibres carrying ibuprofen-grafted NCC for dermal delivery system application. Firstly, NCC was isolated from kapok pulp using multiple acid hydrolysis with the assistance of central composite design to optimise the reaction conditions, namely acid concentration, reaction temperature and time. At the optimum condition, NCC produced showed a rod-like shape with a length of 230.3 ± 39.8 nm, zeta potential of -39.7 ± 0.6 mV, yield of 18.8 ± 1.5% and crystallinity index of 72.6%. 2022-09 Thesis http://eprints.usm.my/59658/ http://eprints.usm.my/59658/1/24%20Pages%20from%20ABDULSALAM%20QAHTAN%20AHMED%20AL%20MASHHADANI%20-%20TESIS.pdf application/pdf en public phd doctoral Perpustakaan Hamzah Sendut Pusat Pengajian Sains Farmasi
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Ahmed Al-Mashhadani, Abdulsalam Qahtan
Development Of Electrospun Nanofibres Containing Ibuprofen Grafted Nanocrystalline Cellulose For Dermal Delivery
description Nanomaterials offer various benefits in dermal drug delivery, including a large surface-to-volume ratio and enhanced drug disposition in the skin. Nanocrystalline cellulose (NCC) is a potential drug nanocarrier due to its abundant surface hydroxyl groups, making it suitable to be grafted with active pharmaceutical ingredients. However, dermal delivery of nanomaterials needs a proper platform to ensure a good distribution in the formulations. The objective of the thesis is to investigate the electrospun nanofibres carrying ibuprofen-grafted NCC for dermal delivery system application. Firstly, NCC was isolated from kapok pulp using multiple acid hydrolysis with the assistance of central composite design to optimise the reaction conditions, namely acid concentration, reaction temperature and time. At the optimum condition, NCC produced showed a rod-like shape with a length of 230.3 ± 39.8 nm, zeta potential of -39.7 ± 0.6 mV, yield of 18.8 ± 1.5% and crystallinity index of 72.6%.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Ahmed Al-Mashhadani, Abdulsalam Qahtan
author_facet Ahmed Al-Mashhadani, Abdulsalam Qahtan
author_sort Ahmed Al-Mashhadani, Abdulsalam Qahtan
title Development Of Electrospun Nanofibres Containing Ibuprofen Grafted Nanocrystalline Cellulose For Dermal Delivery
title_short Development Of Electrospun Nanofibres Containing Ibuprofen Grafted Nanocrystalline Cellulose For Dermal Delivery
title_full Development Of Electrospun Nanofibres Containing Ibuprofen Grafted Nanocrystalline Cellulose For Dermal Delivery
title_fullStr Development Of Electrospun Nanofibres Containing Ibuprofen Grafted Nanocrystalline Cellulose For Dermal Delivery
title_full_unstemmed Development Of Electrospun Nanofibres Containing Ibuprofen Grafted Nanocrystalline Cellulose For Dermal Delivery
title_sort development of electrospun nanofibres containing ibuprofen grafted nanocrystalline cellulose for dermal delivery
granting_institution Perpustakaan Hamzah Sendut
granting_department Pusat Pengajian Sains Farmasi
publishDate 2022
url http://eprints.usm.my/59658/1/24%20Pages%20from%20ABDULSALAM%20QAHTAN%20AHMED%20AL%20MASHHADANI%20-%20TESIS.pdf
_version_ 1794024028784033792

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