Peripheral Antihypertensive Mechanisms Of Zing/Ber Officinale Var. Rubrumin Spontaneously Hypertensive Rats

Hypertension has been associated with end-organ damage that may eventually lead to stroke, heart, and renal failure. Blood pressure variability is possibly the most important determining factor for the end-organ damage. Zingiber officinale var. rubrum (ZOVR) (Halia bara) is a Malay traditional me...

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Main Author:	Razali, Nadiah
Format:	Thesis
Language:	English
Published:	2022
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/60051/1/24%20Pages%20from%20NADIAH%20BINTI%20RAZALI.pdf
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id	my-usm-ep.60051
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spelling	my-usm-ep.600512024-03-05T02:04:15Z Peripheral Antihypertensive Mechanisms Of Zing/Ber Officinale Var. Rubrumin Spontaneously Hypertensive Rats 2022-11 Razali, Nadiah RS1-441 Pharmacy and materia medica Hypertension has been associated with end-organ damage that may eventually lead to stroke, heart, and renal failure. Blood pressure variability is possibly the most important determining factor for the end-organ damage. Zingiber officinale var. rubrum (ZOVR) (Halia bara) is a Malay traditional medicine claimed to have antihypertensive effects. This study investigated the effects of ZOVR (250 mg/kg b.w) on vascular responsiveness and reactivity in spontaneously hypertensive rats (SHRs) and the mechanisms involved. SHRs were orally fed daily for 28 days with ZOVR extracts and non-invasive systolic blood pressure, mean arterial pressure, heart rate and body weight were measured. Vascular reactivity and responsiveness were assessed using isolated aortic rings, anaesthetised non- and pithed rats, respectively. Appropriate agonists and antagonists (L-NAME, indomethacin, methylene blue, atropine, glibenclamide, hexamethonium, prazosin and propranolol) for the mechanism study were employed. All three crude extracts of ZOVR significantly reduced the mean arterial pressure (MAP) of SHRs in comparison or comparable with verapamil during the 28-day daily oral feeding of ZOVR extracts, with petroleum ether extract (ZOP) produced the most antihypertensive effect and selected for fractionation. 2022-11 Thesis http://eprints.usm.my/60051/ http://eprints.usm.my/60051/1/24%20Pages%20from%20NADIAH%20BINTI%20RAZALI.pdf application/pdf en public phd doctoral Perpustakaan Hamzah Sendut Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Razali, Nadiah Peripheral Antihypertensive Mechanisms Of Zing/Ber Officinale Var. Rubrumin Spontaneously Hypertensive Rats
description	Hypertension has been associated with end-organ damage that may eventually lead to stroke, heart, and renal failure. Blood pressure variability is possibly the most important determining factor for the end-organ damage. Zingiber officinale var. rubrum (ZOVR) (Halia bara) is a Malay traditional medicine claimed to have antihypertensive effects. This study investigated the effects of ZOVR (250 mg/kg b.w) on vascular responsiveness and reactivity in spontaneously hypertensive rats (SHRs) and the mechanisms involved. SHRs were orally fed daily for 28 days with ZOVR extracts and non-invasive systolic blood pressure, mean arterial pressure, heart rate and body weight were measured. Vascular reactivity and responsiveness were assessed using isolated aortic rings, anaesthetised non- and pithed rats, respectively. Appropriate agonists and antagonists (L-NAME, indomethacin, methylene blue, atropine, glibenclamide, hexamethonium, prazosin and propranolol) for the mechanism study were employed. All three crude extracts of ZOVR significantly reduced the mean arterial pressure (MAP) of SHRs in comparison or comparable with verapamil during the 28-day daily oral feeding of ZOVR extracts, with petroleum ether extract (ZOP) produced the most antihypertensive effect and selected for fractionation.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Razali, Nadiah
author_facet	Razali, Nadiah
author_sort	Razali, Nadiah
title	Peripheral Antihypertensive Mechanisms Of Zing/Ber Officinale Var. Rubrumin Spontaneously Hypertensive Rats
title_short	Peripheral Antihypertensive Mechanisms Of Zing/Ber Officinale Var. Rubrumin Spontaneously Hypertensive Rats
title_full	Peripheral Antihypertensive Mechanisms Of Zing/Ber Officinale Var. Rubrumin Spontaneously Hypertensive Rats
title_fullStr	Peripheral Antihypertensive Mechanisms Of Zing/Ber Officinale Var. Rubrumin Spontaneously Hypertensive Rats
title_full_unstemmed	Peripheral Antihypertensive Mechanisms Of Zing/Ber Officinale Var. Rubrumin Spontaneously Hypertensive Rats
title_sort	peripheral antihypertensive mechanisms of zing/ber officinale var. rubrumin spontaneously hypertensive rats
granting_institution	Perpustakaan Hamzah Sendut
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2022
url	http://eprints.usm.my/60051/1/24%20Pages%20from%20NADIAH%20BINTI%20RAZALI.pdf
_version_	1794024083400163328

Peripheral Antihypertensive Mechanisms Of Zing/Ber Officinale Var. Rubrumin Spontaneously Hypertensive Rats

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