Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival

Malaysia has one of the highest national incidences of Nasopharyngeal carcinoma (NPC) in South-East Asia. Treating patients with metastatic NPC is often a challenge as patients develop resistance to systemic anti-cancer therapies such as chemotherapy and retreating local recurrence with radiother...

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Main Author:	Abdul Rahman, Siti Fairus
Format:	Thesis
Language:	English
Published:	2022
Subjects:	QH1-278.5 Natural history (General)
Online Access:	http://eprints.usm.my/60127/1/24%20Pages%20from%20SITI%20FAIRUS%20BINTI%20ABDUL%20RAHMAN.pdf
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id	my-usm-ep.60127
record_format	uketd_dc
spelling	my-usm-ep.601272024-03-12T01:53:26Z Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival 2022-11 Abdul Rahman, Siti Fairus QH1-278.5 Natural history (General) Malaysia has one of the highest national incidences of Nasopharyngeal carcinoma (NPC) in South-East Asia. Treating patients with metastatic NPC is often a challenge as patients develop resistance to systemic anti-cancer therapies such as chemotherapy and retreating local recurrence with radiotherapy have many limitations. Hence, improved treatment strategies are needed for better patient outcome. Upregulation of the anti-apoptotic protein BCL-2 is one of the strategies that cancer cells adopt to evade cell death. Hence, these proteins have become attractive therapeutic targets. Given that different cell population rely on different anti-apoptotic proteins for survival, it is crucial to determine which proteins are important for NPC cell survival. Previous study reported that co-inhibition of BCL-2 and BCL-XL did not induce cell killing in NPC cells, which indicate that either MCL-1 or BFL-1 may play an important role in the survival the NPC cells. Given that the roles of MCL-1 and BFL-1 for NPC cell survival are under-explored, this study will primarily focus on delineating the functional roles of these two molecules for cell survival using gene editing and pharmacological approaches. 2022-11 Thesis http://eprints.usm.my/60127/ http://eprints.usm.my/60127/1/24%20Pages%20from%20SITI%20FAIRUS%20BINTI%20ABDUL%20RAHMAN.pdf application/pdf en public phd doctoral Perpustakaan Hamzah Sendut Pusat Pengajian Sains Kajihayat
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	QH1-278.5 Natural history (General)
spellingShingle	QH1-278.5 Natural history (General) Abdul Rahman, Siti Fairus Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival
description	Malaysia has one of the highest national incidences of Nasopharyngeal carcinoma (NPC) in South-East Asia. Treating patients with metastatic NPC is often a challenge as patients develop resistance to systemic anti-cancer therapies such as chemotherapy and retreating local recurrence with radiotherapy have many limitations. Hence, improved treatment strategies are needed for better patient outcome. Upregulation of the anti-apoptotic protein BCL-2 is one of the strategies that cancer cells adopt to evade cell death. Hence, these proteins have become attractive therapeutic targets. Given that different cell population rely on different anti-apoptotic proteins for survival, it is crucial to determine which proteins are important for NPC cell survival. Previous study reported that co-inhibition of BCL-2 and BCL-XL did not induce cell killing in NPC cells, which indicate that either MCL-1 or BFL-1 may play an important role in the survival the NPC cells. Given that the roles of MCL-1 and BFL-1 for NPC cell survival are under-explored, this study will primarily focus on delineating the functional roles of these two molecules for cell survival using gene editing and pharmacological approaches.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Abdul Rahman, Siti Fairus
author_facet	Abdul Rahman, Siti Fairus
author_sort	Abdul Rahman, Siti Fairus
title	Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival
title_short	Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival
title_full	Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival
title_fullStr	Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival
title_full_unstemmed	Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival
title_sort	anti-apoptotic proteins mcl-1 and bcl-xl are crucial for nasopharyngeal carcinoma cell survival
granting_institution	Perpustakaan Hamzah Sendut
granting_department	Pusat Pengajian Sains Kajihayat
publishDate	2022
url	http://eprints.usm.my/60127/1/24%20Pages%20from%20SITI%20FAIRUS%20BINTI%20ABDUL%20RAHMAN.pdf
_version_	1794024093786308608

Anti-Apoptotic Proteins Mcl-1 And Bcl-Xl Are Crucial For Nasopharyngeal Carcinoma Cell Survival

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