The Evaluation Of The Potential Of Tetrahydro-Β-Carboline Derivatives For The Treatment Of Addiction Using In-Vivo Model With Zebrafish And Using Liquid Chromatography-Tandem Mass Spectrometry For The Neurotransmitter Analysis

Drug addiction treatment can include behavioural therapies, medications, or their combination. The available drug used in medication treatment is limited and has known side effects. The present study evaluates the addictive property of synthesized tetrahydro-β-carboline derivatives compounds since t...

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Main Author:	Mohamed, Siti Mazleena
Format:	Thesis
Language:	English
Published:	2022
Subjects:	RM300-666 Drugs and their actions
Online Access:	http://eprints.usm.my/60128/1/24%20Pages%20from%20SITI%20MAZLEENA%20BINTI%20MOHAMED.pdf
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id	my-usm-ep.60128
record_format	uketd_dc
spelling	my-usm-ep.601282024-03-12T01:55:25Z The Evaluation Of The Potential Of Tetrahydro-Β-Carboline Derivatives For The Treatment Of Addiction Using In-Vivo Model With Zebrafish And Using Liquid Chromatography-Tandem Mass Spectrometry For The Neurotransmitter Analysis 2022-10 Mohamed, Siti Mazleena RM300-666 Drugs and their actions Drug addiction treatment can include behavioural therapies, medications, or their combination. The available drug used in medication treatment is limited and has known side effects. The present study evaluates the addictive property of synthesized tetrahydro-β-carboline derivatives compounds since the previous study showed that the compounds positively impact analgesic activity. Forty-nine compounds have been screened for physicochemical properties before selecting further for in-vitro and in-vivo studies. Out of forty-nine compounds, fourteen compounds were chosen for in-vitro screening. Four compounds showed toxicity toward SK-N-SH cells, and two compounds were insoluble in the cell medium. Thus, only eight compounds proceeded for receptor functional activity through cAMP production. (6-methoxy-1,3,4,9-tetrahydro-2H-β-carbolin-2-yl)(phenyl)ethanone (OD1b) and 6-methoxy-2,3,4,9-tetrahydro-1H-β-carbolin-1-one (OD2a) showed the highest cAMP stimulation. Bioavailability radar for drug-likeness showed OD1b and OD2a located inside the optimal range suggesting good drug-like properties of the compounds. The rewarding effects of OD1b and OD2a were evaluated using the behavioural technique of conditioned place preference (CPP) using zebrafish as an animal model, and their neurotransmitters in the brain and body were measured. 2022-10 Thesis http://eprints.usm.my/60128/ http://eprints.usm.my/60128/1/24%20Pages%20from%20SITI%20MAZLEENA%20BINTI%20MOHAMED.pdf application/pdf en public phd doctoral Perpustakaan Hamzah Sendut Pusat Penyelidikan Dadah Dan Ubat-Ubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RM300-666 Drugs and their actions
spellingShingle	RM300-666 Drugs and their actions Mohamed, Siti Mazleena The Evaluation Of The Potential Of Tetrahydro-Β-Carboline Derivatives For The Treatment Of Addiction Using In-Vivo Model With Zebrafish And Using Liquid Chromatography-Tandem Mass Spectrometry For The Neurotransmitter Analysis
description	Drug addiction treatment can include behavioural therapies, medications, or their combination. The available drug used in medication treatment is limited and has known side effects. The present study evaluates the addictive property of synthesized tetrahydro-β-carboline derivatives compounds since the previous study showed that the compounds positively impact analgesic activity. Forty-nine compounds have been screened for physicochemical properties before selecting further for in-vitro and in-vivo studies. Out of forty-nine compounds, fourteen compounds were chosen for in-vitro screening. Four compounds showed toxicity toward SK-N-SH cells, and two compounds were insoluble in the cell medium. Thus, only eight compounds proceeded for receptor functional activity through cAMP production. (6-methoxy-1,3,4,9-tetrahydro-2H-β-carbolin-2-yl)(phenyl)ethanone (OD1b) and 6-methoxy-2,3,4,9-tetrahydro-1H-β-carbolin-1-one (OD2a) showed the highest cAMP stimulation. Bioavailability radar for drug-likeness showed OD1b and OD2a located inside the optimal range suggesting good drug-like properties of the compounds. The rewarding effects of OD1b and OD2a were evaluated using the behavioural technique of conditioned place preference (CPP) using zebrafish as an animal model, and their neurotransmitters in the brain and body were measured.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Mohamed, Siti Mazleena
author_facet	Mohamed, Siti Mazleena
author_sort	Mohamed, Siti Mazleena
title	The Evaluation Of The Potential Of Tetrahydro-Β-Carboline Derivatives For The Treatment Of Addiction Using In-Vivo Model With Zebrafish And Using Liquid Chromatography-Tandem Mass Spectrometry For The Neurotransmitter Analysis
title_short	The Evaluation Of The Potential Of Tetrahydro-Β-Carboline Derivatives For The Treatment Of Addiction Using In-Vivo Model With Zebrafish And Using Liquid Chromatography-Tandem Mass Spectrometry For The Neurotransmitter Analysis
title_full	The Evaluation Of The Potential Of Tetrahydro-Β-Carboline Derivatives For The Treatment Of Addiction Using In-Vivo Model With Zebrafish And Using Liquid Chromatography-Tandem Mass Spectrometry For The Neurotransmitter Analysis
title_fullStr	The Evaluation Of The Potential Of Tetrahydro-Β-Carboline Derivatives For The Treatment Of Addiction Using In-Vivo Model With Zebrafish And Using Liquid Chromatography-Tandem Mass Spectrometry For The Neurotransmitter Analysis
title_full_unstemmed	The Evaluation Of The Potential Of Tetrahydro-Β-Carboline Derivatives For The Treatment Of Addiction Using In-Vivo Model With Zebrafish And Using Liquid Chromatography-Tandem Mass Spectrometry For The Neurotransmitter Analysis
title_sort	evaluation of the potential of tetrahydro-β-carboline derivatives for the treatment of addiction using in-vivo model with zebrafish and using liquid chromatography-tandem mass spectrometry for the neurotransmitter analysis
granting_institution	Perpustakaan Hamzah Sendut
granting_department	Pusat Penyelidikan Dadah Dan Ubat-Ubatan
publishDate	2022
url	http://eprints.usm.my/60128/1/24%20Pages%20from%20SITI%20MAZLEENA%20BINTI%20MOHAMED.pdf
_version_	1794024094034821120

The Evaluation Of The Potential Of Tetrahydro-Β-Carboline Derivatives For The Treatment Of Addiction Using In-Vivo Model With Zebrafish And Using Liquid Chromatography-Tandem Mass Spectrometry For The Neurotransmitter Analysis

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