Evaluation Of Tacrolimus, Associated Adverse Effects, Quality Of Life, And Treatment Satisfaction Among Kidney Transplant Patients In Riyadh, Saudi Arabia

The number of renal transplanted patients in Saudi Arabia is markedly increased. Tacrolimus is a well-known immunosuppressive drug used to prevent allograft rejection. Due to tacrolimus- unwanted adverse effects, narrow therapeutic index, drug-drug interactions, and significant inter-individual vari...

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Main Author:	Ahmed Alboghdadly, Amany Mohamed Hussien
Format:	Thesis
Language:	English
Published:	2023
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/60157/1/24%20Pages%20from%20AMANY%20MOHAMED%20HUSSIEN%20AHMED%20ALBOGHDADLY.pdf
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id	my-usm-ep.60157
record_format	uketd_dc
spelling	my-usm-ep.601572024-03-13T01:39:44Z Evaluation Of Tacrolimus, Associated Adverse Effects, Quality Of Life, And Treatment Satisfaction Among Kidney Transplant Patients In Riyadh, Saudi Arabia 2023-07 Ahmed Alboghdadly, Amany Mohamed Hussien RS1-441 Pharmacy and materia medica The number of renal transplanted patients in Saudi Arabia is markedly increased. Tacrolimus is a well-known immunosuppressive drug used to prevent allograft rejection. Due to tacrolimus- unwanted adverse effects, narrow therapeutic index, drug-drug interactions, and significant inter-individual variability in pharmacokinetics, it requires constant therapeutic drug monitoring. This study aims to determine the tacrolimus-associated adverse effects and the factors associated with their occurrence, acute cellular rejection, and graft loss. Also, to evaluate the relationship between tacrolimus trough concentration (FK506-C0) levels with all of these variables. Finally, the effect of demographic, clinical, and social factors on health-related quality of life (HRQoL) and treatment satisfaction in tacrolimus-treated patients’ post-renal transplantation (RTP) in Saudi population was investigated. It is a pre-experimental study design conducted at the Security Forces Hospital in Riyadh, Saudi Arabia. The study included all patients over the age of 18 who received a kidney transplant between January 2006 and January 2019 and were treated with tacrolimus, mycophenolate mofetil, and prednisolone (322 patients). Patients were monitored at each clinic visit and followed up until September 2019 2023-07 Thesis http://eprints.usm.my/60157/ http://eprints.usm.my/60157/1/24%20Pages%20from%20AMANY%20MOHAMED%20HUSSIEN%20AHMED%20ALBOGHDADLY.pdf application/pdf en public phd doctoral Perpustakaan Hamzah Sendut Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Ahmed Alboghdadly, Amany Mohamed Hussien Evaluation Of Tacrolimus, Associated Adverse Effects, Quality Of Life, And Treatment Satisfaction Among Kidney Transplant Patients In Riyadh, Saudi Arabia
description	The number of renal transplanted patients in Saudi Arabia is markedly increased. Tacrolimus is a well-known immunosuppressive drug used to prevent allograft rejection. Due to tacrolimus- unwanted adverse effects, narrow therapeutic index, drug-drug interactions, and significant inter-individual variability in pharmacokinetics, it requires constant therapeutic drug monitoring. This study aims to determine the tacrolimus-associated adverse effects and the factors associated with their occurrence, acute cellular rejection, and graft loss. Also, to evaluate the relationship between tacrolimus trough concentration (FK506-C0) levels with all of these variables. Finally, the effect of demographic, clinical, and social factors on health-related quality of life (HRQoL) and treatment satisfaction in tacrolimus-treated patients’ post-renal transplantation (RTP) in Saudi population was investigated. It is a pre-experimental study design conducted at the Security Forces Hospital in Riyadh, Saudi Arabia. The study included all patients over the age of 18 who received a kidney transplant between January 2006 and January 2019 and were treated with tacrolimus, mycophenolate mofetil, and prednisolone (322 patients). Patients were monitored at each clinic visit and followed up until September 2019
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Ahmed Alboghdadly, Amany Mohamed Hussien
author_facet	Ahmed Alboghdadly, Amany Mohamed Hussien
author_sort	Ahmed Alboghdadly, Amany Mohamed Hussien
title	Evaluation Of Tacrolimus, Associated Adverse Effects, Quality Of Life, And Treatment Satisfaction Among Kidney Transplant Patients In Riyadh, Saudi Arabia
title_short	Evaluation Of Tacrolimus, Associated Adverse Effects, Quality Of Life, And Treatment Satisfaction Among Kidney Transplant Patients In Riyadh, Saudi Arabia
title_full	Evaluation Of Tacrolimus, Associated Adverse Effects, Quality Of Life, And Treatment Satisfaction Among Kidney Transplant Patients In Riyadh, Saudi Arabia
title_fullStr	Evaluation Of Tacrolimus, Associated Adverse Effects, Quality Of Life, And Treatment Satisfaction Among Kidney Transplant Patients In Riyadh, Saudi Arabia
title_full_unstemmed	Evaluation Of Tacrolimus, Associated Adverse Effects, Quality Of Life, And Treatment Satisfaction Among Kidney Transplant Patients In Riyadh, Saudi Arabia
title_sort	evaluation of tacrolimus, associated adverse effects, quality of life, and treatment satisfaction among kidney transplant patients in riyadh, saudi arabia
granting_institution	Perpustakaan Hamzah Sendut
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2023
url	http://eprints.usm.my/60157/1/24%20Pages%20from%20AMANY%20MOHAMED%20HUSSIEN%20AHMED%20ALBOGHDADLY.pdf
_version_	1794024098022555648

Evaluation Of Tacrolimus, Associated Adverse Effects, Quality Of Life, And Treatment Satisfaction Among Kidney Transplant Patients In Riyadh, Saudi Arabia

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