Development Of Rice Starch Microneedles For Drug Delivery To The Skin

Microneedles (MNs) are minimally invasive biomedical devices that help drugs to bypass the skin barrier, resulting in systemic and localised pharmacological effects. Dissolving MNs are associated with high patient compliance and lower cross-contamination risk as compared to other MN types. Rice star...

Full description

Saved in:

Bibliographic Details
Main Author:	Mahmood Alrimawi, Bilal Harieth
Format:	Thesis
Language:	English
Published:	2023
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/60260/1/24%20Pages%20from%20BILAL%20HARIETH%20MAHMOOD%20ALRIMAWI.pdf
Tags:	Add Tag No Tags, Be the first to tag this record!

id	my-usm-ep.60260
record_format	uketd_dc
spelling	my-usm-ep.602602024-03-25T01:20:32Z Development Of Rice Starch Microneedles For Drug Delivery To The Skin 2023-04 Mahmood Alrimawi, Bilal Harieth RS1-441 Pharmacy and materia medica Microneedles (MNs) are minimally invasive biomedical devices that help drugs to bypass the skin barrier, resulting in systemic and localised pharmacological effects. Dissolving MNs are associated with high patient compliance and lower cross-contamination risk as compared to other MN types. Rice starch (RSC) has a high potential to be used in the development of dissolving MNs owing to its good film-forming properties, biodegradability, non-toxicity, and low cost. However, formulation of dissolving MNs using RSC is challenging due to the inherent brittleness of RSC. This thesis aims to explore RSC as a biopolymer for the fabrication of dissolving MN for drug delivery to the skin. Formulation of dissolving MNs with neat RSC was impossible due to the poor mechanical properties of RSC. Therefore, polymer blends of RSC with polyvinyl alcohol (PVA) or polyvinyl pyrrolidone (PVP) were initially used to develop films as a preliminary investigation before MN development. The addition of PVA or PVP enhanced the mechanical strength and dissolution of RSC-based films. Meanwhile, characterisation of different RSC blends demonstrated that MNs formulated with RSC blends using 20 %w/w of PVA (PVA20-MN) or 40 %w/w of PVP (PVP40-MN) showed intact needle formation with sufficient mechanical strength, skin insertion and dissolution within 60 min. 2023-04 Thesis http://eprints.usm.my/60260/ http://eprints.usm.my/60260/1/24%20Pages%20from%20BILAL%20HARIETH%20MAHMOOD%20ALRIMAWI.pdf application/pdf en public phd doctoral Perpustakaan Hamzah Sendut Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Mahmood Alrimawi, Bilal Harieth Development Of Rice Starch Microneedles For Drug Delivery To The Skin
description	Microneedles (MNs) are minimally invasive biomedical devices that help drugs to bypass the skin barrier, resulting in systemic and localised pharmacological effects. Dissolving MNs are associated with high patient compliance and lower cross-contamination risk as compared to other MN types. Rice starch (RSC) has a high potential to be used in the development of dissolving MNs owing to its good film-forming properties, biodegradability, non-toxicity, and low cost. However, formulation of dissolving MNs using RSC is challenging due to the inherent brittleness of RSC. This thesis aims to explore RSC as a biopolymer for the fabrication of dissolving MN for drug delivery to the skin. Formulation of dissolving MNs with neat RSC was impossible due to the poor mechanical properties of RSC. Therefore, polymer blends of RSC with polyvinyl alcohol (PVA) or polyvinyl pyrrolidone (PVP) were initially used to develop films as a preliminary investigation before MN development. The addition of PVA or PVP enhanced the mechanical strength and dissolution of RSC-based films. Meanwhile, characterisation of different RSC blends demonstrated that MNs formulated with RSC blends using 20 %w/w of PVA (PVA20-MN) or 40 %w/w of PVP (PVP40-MN) showed intact needle formation with sufficient mechanical strength, skin insertion and dissolution within 60 min.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Mahmood Alrimawi, Bilal Harieth
author_facet	Mahmood Alrimawi, Bilal Harieth
author_sort	Mahmood Alrimawi, Bilal Harieth
title	Development Of Rice Starch Microneedles For Drug Delivery To The Skin
title_short	Development Of Rice Starch Microneedles For Drug Delivery To The Skin
title_full	Development Of Rice Starch Microneedles For Drug Delivery To The Skin
title_fullStr	Development Of Rice Starch Microneedles For Drug Delivery To The Skin
title_full_unstemmed	Development Of Rice Starch Microneedles For Drug Delivery To The Skin
title_sort	development of rice starch microneedles for drug delivery to the skin
granting_institution	Perpustakaan Hamzah Sendut
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2023
url	http://eprints.usm.my/60260/1/24%20Pages%20from%20BILAL%20HARIETH%20MAHMOOD%20ALRIMAWI.pdf
_version_	1804888900175396864

Development Of Rice Starch Microneedles For Drug Delivery To The Skin

Similar Items