Etomidate versus ketamine for procedural sedation in paediatric Patients in the emergency department

Etomidate versus ketamine for procedural sedation in paediatric patients in the Emergency Department. The objectives of the study was to compare the sedation time (Ti) between Etomidate versus Ketamine and the safety of both drugs in the procedural sedation and analgesia among paediatric patients...

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Main Author:	Fatan, Ahmad Abdulbasitz Ahmad
Format:	Thesis
Language:	English
Published:	2012
Subjects:	R Medicine (General) RJ Pediatrics
Online Access:	http://eprints.usm.my/60932/1/AHMAD%20ABDULBASITZ%20BIN%20AHMAD%20FATAN%20-%20e.pdf
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id	my-usm-ep.60932
record_format	uketd_dc
spelling	my-usm-ep.609322024-11-17T06:45:03Z Etomidate versus ketamine for procedural sedation in paediatric Patients in the emergency department 2012 Fatan, Ahmad Abdulbasitz Ahmad R Medicine (General) RJ Pediatrics Etomidate versus ketamine for procedural sedation in paediatric patients in the Emergency Department. The objectives of the study was to compare the sedation time (Ti) between Etomidate versus Ketamine and the safety of both drugs in the procedural sedation and analgesia among paediatric patients in Emergency department. A single blinded, randomized control study was conducted in Emergency Department Hospital Universiti Sains Malaysia, Kubang Kerian Kelantan, from 1s’ Jun 2010 untill 31st May 2011. 29 paediatric patients aged from 2 years old until 12 years old were recruited with the permission of their parents. They were randomized to two group, Etomidate group which received IV Fentanyl 1pg/kg plus IV Etomidate 0.2mg/kg and Ketamine group which received IV ketamine 1.5mg/kg. 13 patients randomized to Etomidate group and 16 patients to Ketamine group. Sedation time (Tj) was measured from the start of administrating the sedation drug until patients achieved adequate sedation which is characterized by Ramsay sedation score of 4. Vital sign was monitored and any adverse events documented until patients safely discharged/ admitted. From 29 subjects, only 23 subjects able to achieved adequate sedation level with the study drugs. All subjects who did not achieved adequate sedation level were from Etomidate group. From those 23 subjects, median Ti for Etomidate group was 5.0 minutes (IqR 9.0). In the Ketamine group, the median Ti was 1.5 minutes (IqR 4.0). There was no statistical difference in the Ti between the Etomidate group and Ketamine group (P value = 0.17). In this study, the adverse event that has been documented was retching and vomiting and the incidence between the two groups of study drug was similar and no significant difference. (P value = 0.53). There was no serious adverse effect documented during this study. This study proved that sedation time between Etomidate and Ketamine for the PSA were not significantly differ and Etomidate was less effective for PSA compared to the Ketamine in the paediatric age group. Nevertheless, both groups of sedative agents were relatively safe to be used without any serious adverse effect in the paediatric population in Malaysia. 2012 Thesis http://eprints.usm.my/60932/ http://eprints.usm.my/60932/1/AHMAD%20ABDULBASITZ%20BIN%20AHMAD%20FATAN%20-%20e.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine (General) RJ Pediatrics
spellingShingle	R Medicine (General) RJ Pediatrics Fatan, Ahmad Abdulbasitz Ahmad Etomidate versus ketamine for procedural sedation in paediatric Patients in the emergency department
description	Etomidate versus ketamine for procedural sedation in paediatric patients in the Emergency Department. The objectives of the study was to compare the sedation time (Ti) between Etomidate versus Ketamine and the safety of both drugs in the procedural sedation and analgesia among paediatric patients in Emergency department. A single blinded, randomized control study was conducted in Emergency Department Hospital Universiti Sains Malaysia, Kubang Kerian Kelantan, from 1s’ Jun 2010 untill 31st May 2011. 29 paediatric patients aged from 2 years old until 12 years old were recruited with the permission of their parents. They were randomized to two group, Etomidate group which received IV Fentanyl 1pg/kg plus IV Etomidate 0.2mg/kg and Ketamine group which received IV ketamine 1.5mg/kg. 13 patients randomized to Etomidate group and 16 patients to Ketamine group. Sedation time (Tj) was measured from the start of administrating the sedation drug until patients achieved adequate sedation which is characterized by Ramsay sedation score of 4. Vital sign was monitored and any adverse events documented until patients safely discharged/ admitted. From 29 subjects, only 23 subjects able to achieved adequate sedation level with the study drugs. All subjects who did not achieved adequate sedation level were from Etomidate group. From those 23 subjects, median Ti for Etomidate group was 5.0 minutes (IqR 9.0). In the Ketamine group, the median Ti was 1.5 minutes (IqR 4.0). There was no statistical difference in the Ti between the Etomidate group and Ketamine group (P value = 0.17). In this study, the adverse event that has been documented was retching and vomiting and the incidence between the two groups of study drug was similar and no significant difference. (P value = 0.53). There was no serious adverse effect documented during this study. This study proved that sedation time between Etomidate and Ketamine for the PSA were not significantly differ and Etomidate was less effective for PSA compared to the Ketamine in the paediatric age group. Nevertheless, both groups of sedative agents were relatively safe to be used without any serious adverse effect in the paediatric population in Malaysia.
format	Thesis
qualification_level	Master's degree
author	Fatan, Ahmad Abdulbasitz Ahmad
author_facet	Fatan, Ahmad Abdulbasitz Ahmad
author_sort	Fatan, Ahmad Abdulbasitz Ahmad
title	Etomidate versus ketamine for procedural sedation in paediatric Patients in the emergency department
title_short	Etomidate versus ketamine for procedural sedation in paediatric Patients in the emergency department
title_full	Etomidate versus ketamine for procedural sedation in paediatric Patients in the emergency department
title_fullStr	Etomidate versus ketamine for procedural sedation in paediatric Patients in the emergency department
title_full_unstemmed	Etomidate versus ketamine for procedural sedation in paediatric Patients in the emergency department
title_sort	etomidate versus ketamine for procedural sedation in paediatric patients in the emergency department
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2012
url	http://eprints.usm.my/60932/1/AHMAD%20ABDULBASITZ%20BIN%20AHMAD%20FATAN%20-%20e.pdf
_version_	1818647359406473216

Etomidate versus ketamine for procedural sedation in paediatric Patients in the emergency department

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