Correlation of apoptotic related protiens and clinicopathological parameters in liposarcoma

Information on prognostic factors is important to setup a proper therapeutic modalities for soft tissue sarcomas. Tumor growth depends on two distinctive pathways: cell proliferation and apoptosis. Liposarcoma is one of the most common soft tissue sarcomas (account about 20-30%), thus this study was...

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Main Author:	Abd Alabbas, Haider K.
Format:	Thesis
Language:	English
Published:	2012
Subjects:	R Medicine (General) RC31-1245 Internal medicine
Online Access:	http://eprints.usm.my/60987/1/DR%20HAIDER%20K.%20ABD%20ALABBAS%20-%20e.pdf
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id	my-usm-ep.60987
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spelling	my-usm-ep.609872024-11-17T04:02:32Z Correlation of apoptotic related protiens and clinicopathological parameters in liposarcoma 2012 Abd Alabbas, Haider K. R Medicine (General) RC254-282 Neoplasms. Tumors. Oncology (including Cancer) RC31-1245 Internal medicine Information on prognostic factors is important to setup a proper therapeutic modalities for soft tissue sarcomas. Tumor growth depends on two distinctive pathways: cell proliferation and apoptosis. Liposarcoma is one of the most common soft tissue sarcomas (account about 20-30%), thus this study was designed to look into apoptotic activity of LPS as single entity. In relation to that, we also try to correlate the relationship between apoptotic activity and the clinic-pathological parameters. A cross sectional study was conducted from April 2009 To October 2011. 45 cases of different histologic subtypes of LPS were included in this study. Tissue sections that were retrieved from archived tissue blocks were stained with immunohistochemical stain for Bcl-2 and Bax proteins. Higher expression of Bax in the tumor cells (71.1%) was seen compared to the expression of Bcl-2 (48.9%). Significant correlation between the expression of Bcl-2 and tumor grade (p< 0.005) and histologic subtypes (p<0.001) were found. At the same time Bax expression is higher in LPS and significantly correlate with histological grade and the site of the tumors (p<0.048) and histologic grade (p<0.014). However, there were no correlation between apoptotic activity and tumor size, tumor depth and surgical margins. In conclusion, apoptotic activity plays an important role in tumor developments and progression. Immunohistochemical detection of the proteins used in this study might be useful as markers for predicting the prognosis in LPS. 2012 Thesis http://eprints.usm.my/60987/ http://eprints.usm.my/60987/1/DR%20HAIDER%20K.%20ABD%20ALABBAS%20-%20e.pdf application/pdf en public masters Universiti Sains Malaysia Pusat Pengajian Sains Perubatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine (General) R Medicine (General) RC31-1245 Internal medicine
spellingShingle	R Medicine (General) R Medicine (General) RC31-1245 Internal medicine Abd Alabbas, Haider K. Correlation of apoptotic related protiens and clinicopathological parameters in liposarcoma
description	Information on prognostic factors is important to setup a proper therapeutic modalities for soft tissue sarcomas. Tumor growth depends on two distinctive pathways: cell proliferation and apoptosis. Liposarcoma is one of the most common soft tissue sarcomas (account about 20-30%), thus this study was designed to look into apoptotic activity of LPS as single entity. In relation to that, we also try to correlate the relationship between apoptotic activity and the clinic-pathological parameters. A cross sectional study was conducted from April 2009 To October 2011. 45 cases of different histologic subtypes of LPS were included in this study. Tissue sections that were retrieved from archived tissue blocks were stained with immunohistochemical stain for Bcl-2 and Bax proteins. Higher expression of Bax in the tumor cells (71.1%) was seen compared to the expression of Bcl-2 (48.9%). Significant correlation between the expression of Bcl-2 and tumor grade (p< 0.005) and histologic subtypes (p<0.001) were found. At the same time Bax expression is higher in LPS and significantly correlate with histological grade and the site of the tumors (p<0.048) and histologic grade (p<0.014). However, there were no correlation between apoptotic activity and tumor size, tumor depth and surgical margins. In conclusion, apoptotic activity plays an important role in tumor developments and progression. Immunohistochemical detection of the proteins used in this study might be useful as markers for predicting the prognosis in LPS.
format	Thesis
qualification_level	Master's degree
author	Abd Alabbas, Haider K.
author_facet	Abd Alabbas, Haider K.
author_sort	Abd Alabbas, Haider K.
title	Correlation of apoptotic related protiens and clinicopathological parameters in liposarcoma
title_short	Correlation of apoptotic related protiens and clinicopathological parameters in liposarcoma
title_full	Correlation of apoptotic related protiens and clinicopathological parameters in liposarcoma
title_fullStr	Correlation of apoptotic related protiens and clinicopathological parameters in liposarcoma
title_full_unstemmed	Correlation of apoptotic related protiens and clinicopathological parameters in liposarcoma
title_sort	correlation of apoptotic related protiens and clinicopathological parameters in liposarcoma
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Perubatan
publishDate	2012
url	http://eprints.usm.my/60987/1/DR%20HAIDER%20K.%20ABD%20ALABBAS%20-%20e.pdf
_version_	1818647365624528896

Correlation of apoptotic related protiens and clinicopathological parameters in liposarcoma

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