Dosimetric verification of monaco treatment planning system (TPS) in heterogeneous medium for 6 mv linac

The Monaco TPS, employing the Monte Carlo dose calculation algorithm, offers high precision in radiotherapy planning. Accurate dose calculation in heterogeneous tissues necessitates comprehensive commissioning and verification due to its impact on patient outcomes. This study evaluates the dose calc...

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Main Author:	Azlan, Adriana Batrisyia Noor Mohd
Format:	Thesis
Language:	English
Published:	2024
Subjects:	R Medicine
Online Access:	http://eprints.usm.my/61084/1/Adriana%20Batrisyia%20Noor%20Mohd%20Azlan-E.pdf
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spelling	my-usm-ep.610842024-10-17T05:17:39Z Dosimetric verification of monaco treatment planning system (TPS) in heterogeneous medium for 6 mv linac 2024-07 Azlan, Adriana Batrisyia Noor Mohd R Medicine RA440-440.87 Study and teaching. Research The Monaco TPS, employing the Monte Carlo dose calculation algorithm, offers high precision in radiotherapy planning. Accurate dose calculation in heterogeneous tissues necessitates comprehensive commissioning and verification due to its impact on patient outcomes. This study evaluates the dose calculation accuracy of Monaco TPS using Rando phantoms, thermoluminescence dosimeters (TLD-100) dosimeters, EBT3 Gafchromic films, and clinical patient data through patient-specific quality assurance (PSQA). Methods : Dosimetric verification of Monaco TPS was conducted on a head and neck Rando phantom for 3D conformal radiotherapy (3DCRT) whole brain radiotherapy (WBRT) and volumetric modulated arc therapy (VMAT) meningioma planning in heterogeneous environments, using 12 TLD-100s and EBT3 Gafchromic films. Additionally, six Eclipse TPS patient plans were replicated on Monaco TPS, and PSQA was performed using gamma criteria of 3% dose difference (DD) and 3 mm distance-to-agreement (DTA). Results :Monaco TPS demonstrated consistent percentage deviations within ±10% (ranging from 1.8% to 9.1%) between TPS calculated and TLD-measured doses for 3DCRT, with no significant difference (p > 0.05). EBT3 Gafchromic film dosimetry showed good agreement with TPS dose distributions, achieving a 97.3% gamma passing rate. However, VMAT planning revealed significant deviations (3.06% to 67.88%) between calculated and measured doses, with a significant difference (p < 0.01) and a 52.5% gamma passing rate for film dosimetry. PSQA for six patient plans yielded high gamma passing rates (97.5% to 100%) and absolute dose deviations ranging from 0.29% to 3.48%.Conclusion : Monaco TPS is reliable and accurately commissioned for 3DCRT planning but shows significant deviations in VMAT planning. Future efforts should aim to improve verification methods, address challenges in gamma index analysis, and enhance VMAT dose calculation accuracy for consistent treatment planning. 2024-07 Thesis http://eprints.usm.my/61084/ http://eprints.usm.my/61084/1/Adriana%20Batrisyia%20Noor%20Mohd%20Azlan-E.pdf application/pdf en public other Universiti Sains Malaysia Pusat Pengajian Sains Kesihatan
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	R Medicine R Medicine
spellingShingle	R Medicine R Medicine Azlan, Adriana Batrisyia Noor Mohd Dosimetric verification of monaco treatment planning system (TPS) in heterogeneous medium for 6 mv linac
description	The Monaco TPS, employing the Monte Carlo dose calculation algorithm, offers high precision in radiotherapy planning. Accurate dose calculation in heterogeneous tissues necessitates comprehensive commissioning and verification due to its impact on patient outcomes. This study evaluates the dose calculation accuracy of Monaco TPS using Rando phantoms, thermoluminescence dosimeters (TLD-100) dosimeters, EBT3 Gafchromic films, and clinical patient data through patient-specific quality assurance (PSQA). Methods : Dosimetric verification of Monaco TPS was conducted on a head and neck Rando phantom for 3D conformal radiotherapy (3DCRT) whole brain radiotherapy (WBRT) and volumetric modulated arc therapy (VMAT) meningioma planning in heterogeneous environments, using 12 TLD-100s and EBT3 Gafchromic films. Additionally, six Eclipse TPS patient plans were replicated on Monaco TPS, and PSQA was performed using gamma criteria of 3% dose difference (DD) and 3 mm distance-to-agreement (DTA). Results :Monaco TPS demonstrated consistent percentage deviations within ±10% (ranging from 1.8% to 9.1%) between TPS calculated and TLD-measured doses for 3DCRT, with no significant difference (p > 0.05). EBT3 Gafchromic film dosimetry showed good agreement with TPS dose distributions, achieving a 97.3% gamma passing rate. However, VMAT planning revealed significant deviations (3.06% to 67.88%) between calculated and measured doses, with a significant difference (p < 0.01) and a 52.5% gamma passing rate for film dosimetry. PSQA for six patient plans yielded high gamma passing rates (97.5% to 100%) and absolute dose deviations ranging from 0.29% to 3.48%.Conclusion : Monaco TPS is reliable and accurately commissioned for 3DCRT planning but shows significant deviations in VMAT planning. Future efforts should aim to improve verification methods, address challenges in gamma index analysis, and enhance VMAT dose calculation accuracy for consistent treatment planning.
format	Thesis
qualification_level	other
author	Azlan, Adriana Batrisyia Noor Mohd
author_facet	Azlan, Adriana Batrisyia Noor Mohd
author_sort	Azlan, Adriana Batrisyia Noor Mohd
title	Dosimetric verification of monaco treatment planning system (TPS) in heterogeneous medium for 6 mv linac
title_short	Dosimetric verification of monaco treatment planning system (TPS) in heterogeneous medium for 6 mv linac
title_full	Dosimetric verification of monaco treatment planning system (TPS) in heterogeneous medium for 6 mv linac
title_fullStr	Dosimetric verification of monaco treatment planning system (TPS) in heterogeneous medium for 6 mv linac
title_full_unstemmed	Dosimetric verification of monaco treatment planning system (TPS) in heterogeneous medium for 6 mv linac
title_sort	dosimetric verification of monaco treatment planning system (tps) in heterogeneous medium for 6 mv linac
granting_institution	Universiti Sains Malaysia
granting_department	Pusat Pengajian Sains Kesihatan
publishDate	2024
url	http://eprints.usm.my/61084/1/Adriana%20Batrisyia%20Noor%20Mohd%20Azlan-E.pdf
_version_	1818647372625870848

Dosimetric verification of monaco treatment planning system (TPS) in heterogeneous medium for 6 mv linac

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