Theobromine-Based Synthetic Derivatives As Potential Inhibitors Of Dengue Virus Ii Serine Protease

Dengue is an RNA viral disease that is spread across tropical and subtropical urbanised districts. Up to June 2022, more than 17,497 cases of dengue infections have been reported in Malaysia since the beginning of the year, which is considered an increment of 57.6% compared to the first six month...

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Main Author:	Saqallah, Fadi Ghassan Mohammed
Format:	Thesis
Language:	English
Published:	2023
Subjects:	RS1-441 Pharmacy and materia medica
Online Access:	http://eprints.usm.my/61265/1/24%20Pages%20from%20FADI%20GHASSAN%20MOHAMMED%20SAQALLAH.pdf
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id	my-usm-ep.61265
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spelling	my-usm-ep.612652024-10-11T00:58:46Z Theobromine-Based Synthetic Derivatives As Potential Inhibitors Of Dengue Virus Ii Serine Protease 2023-02 Saqallah, Fadi Ghassan Mohammed RS1-441 Pharmacy and materia medica Dengue is an RNA viral disease that is spread across tropical and subtropical urbanised districts. Up to June 2022, more than 17,497 cases of dengue infections have been reported in Malaysia since the beginning of the year, which is considered an increment of 57.6% compared to the first six months of 2021. Moreover, up to date, there is no licensed drug treatment for the management of dengue infections. Dengue virus (DENV) uses the NS2B/NS3 protease to cleave its polyprotein throughout the virus’s replication and life cycle. Hence, inhibiting the viral protease can suppress the replication of DENV. Previously, some unpublished data by our group showed that Theobroma cacao inhibited the DENV2 protease. Theobromine is a naturally occurring alkaloid commonly found in Theobroma cacao. Theobromine has a purine chemical scaffold which resembles that of 19 famous antivirals, which are either commercially available or under clinical investigations, including acyclovir. Moreover, only a few studies have reported the synthesis of theobromine and its derivatives, but to date, none have been related to antiviral agents. In this study, a group of 137 theobromine-based hybrid molecules were designed by conjugating theobromine (at position °1; the secondary amine) with other commercially available chemical entities and compounds. 2023-02 Thesis http://eprints.usm.my/61265/ http://eprints.usm.my/61265/1/24%20Pages%20from%20FADI%20GHASSAN%20MOHAMMED%20SAQALLAH.pdf application/pdf en public phd doctoral Perpustakaan Hamzah Sendut Pusat Pengajian Sains Farmasi
institution	Universiti Sains Malaysia
collection	USM Institutional Repository
language	English
topic	RS1-441 Pharmacy and materia medica
spellingShingle	RS1-441 Pharmacy and materia medica Saqallah, Fadi Ghassan Mohammed Theobromine-Based Synthetic Derivatives As Potential Inhibitors Of Dengue Virus Ii Serine Protease
description	Dengue is an RNA viral disease that is spread across tropical and subtropical urbanised districts. Up to June 2022, more than 17,497 cases of dengue infections have been reported in Malaysia since the beginning of the year, which is considered an increment of 57.6% compared to the first six months of 2021. Moreover, up to date, there is no licensed drug treatment for the management of dengue infections. Dengue virus (DENV) uses the NS2B/NS3 protease to cleave its polyprotein throughout the virus’s replication and life cycle. Hence, inhibiting the viral protease can suppress the replication of DENV. Previously, some unpublished data by our group showed that Theobroma cacao inhibited the DENV2 protease. Theobromine is a naturally occurring alkaloid commonly found in Theobroma cacao. Theobromine has a purine chemical scaffold which resembles that of 19 famous antivirals, which are either commercially available or under clinical investigations, including acyclovir. Moreover, only a few studies have reported the synthesis of theobromine and its derivatives, but to date, none have been related to antiviral agents. In this study, a group of 137 theobromine-based hybrid molecules were designed by conjugating theobromine (at position °1; the secondary amine) with other commercially available chemical entities and compounds.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Saqallah, Fadi Ghassan Mohammed
author_facet	Saqallah, Fadi Ghassan Mohammed
author_sort	Saqallah, Fadi Ghassan Mohammed
title	Theobromine-Based Synthetic Derivatives As Potential Inhibitors Of Dengue Virus Ii Serine Protease
title_short	Theobromine-Based Synthetic Derivatives As Potential Inhibitors Of Dengue Virus Ii Serine Protease
title_full	Theobromine-Based Synthetic Derivatives As Potential Inhibitors Of Dengue Virus Ii Serine Protease
title_fullStr	Theobromine-Based Synthetic Derivatives As Potential Inhibitors Of Dengue Virus Ii Serine Protease
title_full_unstemmed	Theobromine-Based Synthetic Derivatives As Potential Inhibitors Of Dengue Virus Ii Serine Protease
title_sort	theobromine-based synthetic derivatives as potential inhibitors of dengue virus ii serine protease
granting_institution	Perpustakaan Hamzah Sendut
granting_department	Pusat Pengajian Sains Farmasi
publishDate	2023
url	http://eprints.usm.my/61265/1/24%20Pages%20from%20FADI%20GHASSAN%20MOHAMMED%20SAQALLAH.pdf
_version_	1818647381642575872

Theobromine-Based Synthetic Derivatives As Potential Inhibitors Of Dengue Virus Ii Serine Protease

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