Development And Characterisation Of Electrospun Solid Dispersions Of Atovaquone For Enhanced Buccal Drug Delivery

Development And Characterisation Of Electrospun Solid Dispersions Of Atovaquone For Enhanced Buccal Drug Delivery

The present study investigated a poorly aqueous soluble drug, atovaquone (ATQ) formulated using an electrospinning solid dispersion strategy with polymer carrier systems. Thermal treatment was applied to ATQ form I and reported heat-sensitive properties where it sublimates and degrades before meltin...

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Main Author: Teoh, Xin Yi
Format: Thesis
Language:English
Published: 2023
Subjects:
RS1-441 Pharmacy and materia medica
Online Access:http://eprints.usm.my/61343/1/24%20Pages%20from%20TEOH%20XIN%20YI.pdf
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spelling my-usm-ep.613432024-10-22T00:40:03Z Development And Characterisation Of Electrospun Solid Dispersions Of Atovaquone For Enhanced Buccal Drug Delivery 2023-02 Teoh, Xin Yi RS1-441 Pharmacy and materia medica The present study investigated a poorly aqueous soluble drug, atovaquone (ATQ) formulated using an electrospinning solid dispersion strategy with polymer carrier systems. Thermal treatment was applied to ATQ form I and reported heat-sensitive properties where it sublimates and degrades before melting temperature. Following the thermal treatment, a new polymorph (ATQ form sub/eva) was obtained as a result of sublimation and evaporation. Besides, an anomalous stepwise transition circa -20°C was identified from the ATQ produced via melt-quenching demonstrating the possibility of ATQ amorphisation. Subsequently, a non-heat invasive electrospinning technique was utilised to produce solid dispersions of ATQ with the polymer PVPVA or/and PVP. High content recovery of ATQ electrospun samples was quantitated by a novel HPLC method developed herein. Hydrogen bonding interactions between ATQ and polymers were identified through ATR-FTIR analysis. A reduction of ATQ crystallinity was confirmed in the electrospun samples and the ATQ electrospun solid dispersions have been shown to improve the solubility and drug release profiles compared to the raw crystalline ATQ. However, there was no proportional relationship between the degree of crystallinity reduction and the improvement of the drug release profile reported. Instead, an optimisation of the hydrophilic-hydrophobic balance of the polymeric system was highlighted to sustain the supersaturation state by preventing solution-mediated recrystallisation of the electrospun samples. 2023-02 Thesis http://eprints.usm.my/61343/ http://eprints.usm.my/61343/1/24%20Pages%20from%20TEOH%20XIN%20YI.pdf application/pdf en public phd doctoral Perpustakaan Hamzah Sendut Pusat Pengajian Sains Farmasi
institution Universiti Sains Malaysia
collection USM Institutional Repository
language English
topic RS1-441 Pharmacy and materia medica
spellingShingle RS1-441 Pharmacy and materia medica
Teoh, Xin Yi
Development And Characterisation Of Electrospun Solid Dispersions Of Atovaquone For Enhanced Buccal Drug Delivery
description The present study investigated a poorly aqueous soluble drug, atovaquone (ATQ) formulated using an electrospinning solid dispersion strategy with polymer carrier systems. Thermal treatment was applied to ATQ form I and reported heat-sensitive properties where it sublimates and degrades before melting temperature. Following the thermal treatment, a new polymorph (ATQ form sub/eva) was obtained as a result of sublimation and evaporation. Besides, an anomalous stepwise transition circa -20°C was identified from the ATQ produced via melt-quenching demonstrating the possibility of ATQ amorphisation. Subsequently, a non-heat invasive electrospinning technique was utilised to produce solid dispersions of ATQ with the polymer PVPVA or/and PVP. High content recovery of ATQ electrospun samples was quantitated by a novel HPLC method developed herein. Hydrogen bonding interactions between ATQ and polymers were identified through ATR-FTIR analysis. A reduction of ATQ crystallinity was confirmed in the electrospun samples and the ATQ electrospun solid dispersions have been shown to improve the solubility and drug release profiles compared to the raw crystalline ATQ. However, there was no proportional relationship between the degree of crystallinity reduction and the improvement of the drug release profile reported. Instead, an optimisation of the hydrophilic-hydrophobic balance of the polymeric system was highlighted to sustain the supersaturation state by preventing solution-mediated recrystallisation of the electrospun samples.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Teoh, Xin Yi
author_facet Teoh, Xin Yi
author_sort Teoh, Xin Yi
title Development And Characterisation Of Electrospun Solid Dispersions Of Atovaquone For Enhanced Buccal Drug Delivery
title_short Development And Characterisation Of Electrospun Solid Dispersions Of Atovaquone For Enhanced Buccal Drug Delivery
title_full Development And Characterisation Of Electrospun Solid Dispersions Of Atovaquone For Enhanced Buccal Drug Delivery
title_fullStr Development And Characterisation Of Electrospun Solid Dispersions Of Atovaquone For Enhanced Buccal Drug Delivery
title_full_unstemmed Development And Characterisation Of Electrospun Solid Dispersions Of Atovaquone For Enhanced Buccal Drug Delivery
title_sort development and characterisation of electrospun solid dispersions of atovaquone for enhanced buccal drug delivery
granting_institution Perpustakaan Hamzah Sendut
granting_department Pusat Pengajian Sains Farmasi
publishDate 2023
url http://eprints.usm.my/61343/1/24%20Pages%20from%20TEOH%20XIN%20YI.pdf
_version_ 1818647398506823680

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