Study of biomechanical properties of articular cartilage using low-field magnetic resonance imaging

Osteoarthritis (OA) is a major health issues among the population, causing pain in the human joints. It is well recognised that the OA is mainly caused by the degeneration of articular cartilage. The earliest stage of OA resulted in the alteration of the biomechanical properties of cartilage elastic...

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Main Author:	Yew, Wansin
Format:	Thesis
Language:	English English
Published:	2017
Subjects:	T Technology (General)
Online Access:	http://eprints.utem.edu.my/id/eprint/20555/1/Study%20Of%20Biomechanical%20Properties%20Of%20Articular%20Cartilage%20Using%20Low-Field%20Magnetic%20Resonance%20Imaging.pdf http://eprints.utem.edu.my/id/eprint/20555/2/Study%20of%20biomechanical%20properties%20of%20articular%20cartilage%20using%20low-field%20magnetic%20resonance%20imaging.pdf
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institution	Universiti Teknikal Malaysia Melaka
collection	UTeM Repository
language	English English
advisor	Abd Latif, Mohd Juzaila
topic	T Technology (General) T Technology (General)
spellingShingle	T Technology (General) T Technology (General) Yew, Wansin Study of biomechanical properties of articular cartilage using low-field magnetic resonance imaging
description	Osteoarthritis (OA) is a major health issues among the population, causing pain in the human joints. It is well recognised that the OA is mainly caused by the degeneration of articular cartilage. The earliest stage of OA resulted in the alteration of the biomechanical properties of cartilage elastic modulus and permeability. Hence, the ability to detect the disease at its earliest stage is crucial for early intervention of the disease. MRI technique is widely used to assess the condition of the articular cartilage by examining the geometrical data. However, most of the diagnoses were performed at the progressive stage of osteoarthritis. Furthermore, most of the previous works and current clinical procedures were performed using high-field MRI which require significant purchase and maintenance costs. Therefore, this study aimed to investigate the potential application of low-field MRI image in order to examine the condition of articular cartilage. Cartilage specimens obtained from the humeral head of bovine were scanned using 0.18 T MRI. It was found that the gradient echo sequence of the low-field MRI was the most suitable sequence to image the cartilage. The images of cartilage were characterised based on the intensity of the greyscale. Creep indentation test was then conducted on the cartilage specimens and subsequently the indentation test was simulated using finite element method. The biomechanical properties of cartilage elastic modulus and permeability were characterized by integrating the experimental indentation test data and computational finite element model. The average elastic modulus was found to be 0.93 ± 0.72 MPa while the permeability was 0.58 ± 0.31 ×10-15m4/Ns. Correlation analyses were performed to examine the relationship between the greyscale of MRI image and biomechanical properties of elastic modulus and permeability of the cartilage. It was found that the cartilage greyscale was moderately correlated with cartilage biphasic elastic modulus (r= 0. 513) and higher correlation was observed with the permeability (r= 0.613). Thus, present results indicate that the low-field MRI have the potential and provide promising insight to determine the condition of articular cartilage. It could be further develop to serve as an early intervention of OA disease.
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Yew, Wansin
author_facet	Yew, Wansin
author_sort	Yew, Wansin
title	Study of biomechanical properties of articular cartilage using low-field magnetic resonance imaging
title_short	Study of biomechanical properties of articular cartilage using low-field magnetic resonance imaging
title_full	Study of biomechanical properties of articular cartilage using low-field magnetic resonance imaging
title_fullStr	Study of biomechanical properties of articular cartilage using low-field magnetic resonance imaging
title_full_unstemmed	Study of biomechanical properties of articular cartilage using low-field magnetic resonance imaging
title_sort	study of biomechanical properties of articular cartilage using low-field magnetic resonance imaging
granting_institution	Universiti Teknikal Malaysia Melaka
granting_department	Faculty Of Mechanical Engineering
publishDate	2017
url	http://eprints.utem.edu.my/id/eprint/20555/1/Study%20Of%20Biomechanical%20Properties%20Of%20Articular%20Cartilage%20Using%20Low-Field%20Magnetic%20Resonance%20Imaging.pdf http://eprints.utem.edu.my/id/eprint/20555/2/Study%20of%20biomechanical%20properties%20of%20articular%20cartilage%20using%20low-field%20magnetic%20resonance%20imaging.pdf
_version_	1747833980839788544
spelling	my-utem-ep.205552022-06-02T08:17:28Z Study of biomechanical properties of articular cartilage using low-field magnetic resonance imaging 2017 Yew, Wansin T Technology (General) TK Electrical engineering. Electronics Nuclear engineering Osteoarthritis (OA) is a major health issues among the population, causing pain in the human joints. It is well recognised that the OA is mainly caused by the degeneration of articular cartilage. The earliest stage of OA resulted in the alteration of the biomechanical properties of cartilage elastic modulus and permeability. Hence, the ability to detect the disease at its earliest stage is crucial for early intervention of the disease. MRI technique is widely used to assess the condition of the articular cartilage by examining the geometrical data. However, most of the diagnoses were performed at the progressive stage of osteoarthritis. Furthermore, most of the previous works and current clinical procedures were performed using high-field MRI which require significant purchase and maintenance costs. Therefore, this study aimed to investigate the potential application of low-field MRI image in order to examine the condition of articular cartilage. Cartilage specimens obtained from the humeral head of bovine were scanned using 0.18 T MRI. It was found that the gradient echo sequence of the low-field MRI was the most suitable sequence to image the cartilage. The images of cartilage were characterised based on the intensity of the greyscale. Creep indentation test was then conducted on the cartilage specimens and subsequently the indentation test was simulated using finite element method. The biomechanical properties of cartilage elastic modulus and permeability were characterized by integrating the experimental indentation test data and computational finite element model. The average elastic modulus was found to be 0.93 ± 0.72 MPa while the permeability was 0.58 ± 0.31 ×10-15m4/Ns. Correlation analyses were performed to examine the relationship between the greyscale of MRI image and biomechanical properties of elastic modulus and permeability of the cartilage. It was found that the cartilage greyscale was moderately correlated with cartilage biphasic elastic modulus (r= 0. 513) and higher correlation was observed with the permeability (r= 0.613). Thus, present results indicate that the low-field MRI have the potential and provide promising insight to determine the condition of articular cartilage. It could be further develop to serve as an early intervention of OA disease. 2017 Thesis http://eprints.utem.edu.my/id/eprint/20555/ http://eprints.utem.edu.my/id/eprint/20555/1/Study%20Of%20Biomechanical%20Properties%20Of%20Articular%20Cartilage%20Using%20Low-Field%20Magnetic%20Resonance%20Imaging.pdf text en public http://eprints.utem.edu.my/id/eprint/20555/2/Study%20of%20biomechanical%20properties%20of%20articular%20cartilage%20using%20low-field%20magnetic%20resonance%20imaging.pdf text en validuser https://plh.utem.edu.my/cgi-bin/koha/opac-detail.pl?biblionumber=105831 mphil masters Universiti Teknikal Malaysia Melaka Faculty Of Mechanical Engineering Abd Latif, Mohd Juzaila 1. Adam, C., Eckstein, F., Milz, S., and Putz, R., 1998. The Distribution of Cartilage Thickness within the Joints of the Lower Limb of Elderly Individuals. Journal of Anatomy, 193(2), pp. 203–214. 2. Agnesi, F., Amrami, K.K., Frigo, C.A., and Kaufman, K.R., 2007. 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Study of biomechanical properties of articular cartilage using low-field magnetic resonance imaging

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