Preparation and characterization of poly (methyl methacrylate)-silver nanoparticles polymer composite as a dental prosthesis
Silver nanoparticles (AgNPs) have been used for centuries in the field of medicine due to the its antimicrobial properties. AgNPs had been synthesized and incorporated in different aspects of biomaterials. According to previous studies, AgNPs provides sufficient antimicrobial effect at lower filler...
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| Format: | Thesis |
| Language: | English English English |
| Published: |
2023
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| Subjects: | |
| Online Access: | http://eprints.uthm.edu.my/10970/1/24p%20ADEL%20BENDJAMA.pdf http://eprints.uthm.edu.my/10970/2/ADEL%20BENDJAMA%20COPYRIGHT%20DECLARATION.pdf http://eprints.uthm.edu.my/10970/3/ADEL%20BENDJAMA%20WATERMARK.pdf |
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| Summary: | Silver nanoparticles (AgNPs) have been used for centuries in the field of medicine due to the its antimicrobial properties. AgNPs had been synthesized and incorporated in different aspects of biomaterials. According to previous studies, AgNPs provides sufficient antimicrobial effect at lower filler level by increasing membrane permeability and destroying bacteria due to its small size. Therefore, AgNPs can be used in dentistry towards prevention and reduction of biofilm formation on the surfaces of dental prosthesis. The main objective of this study is to synthesize poly (methyl methacrylate)-silver nanoparticles antimicrobial acrylic resin for dental prosthesis. The antibacterial effect of the AgNPs incorporated into acrylic resin poly methyl methacrylate (PMMA) was studied and the incorporating effects on the thermal stability of these polymeric biocides were evaluated. Colloidal AgNPs were added to PMMA (ONDA-CRYL) with different concentration (0.021 mg/ml, 0.0525 mg/ml, 0.084 mg/ml). The antimicrobial activity of the silver nanoparticle incorporated into PMMA was measured using disk diffusion method. Thermal stability, morphological and average size, and size distribution of AgNPs/PMMA were determined by transmission electron microscope, scanning electron microscope, and X-ray diffraction. The thermal stability and the glass transition temperature of the four samples were determined by using the thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) analysis. From this study, it was found that the modified PMMA prosthesis base containing 0.084 mg/ml of AgNPs (S3) significantly exhibited antimicrobial properties in vitro, where the number of biofilm bacteria formed is 1.104/ml comparing with the control sample (S0). The incorporation of AgNPs at concentration 0.084 mg/ml to PMMA shows thermal stability at temperature of 350oC-370oC without altering their mechanical properties. Therefore, the AgNPs-PMMA nanocomposite could be used as a dental prosthesis |
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