Reflectance spectroscopy system for real time and non-invasive detection of transcutaneous bilirubin level

Blood bilirubin level would be elevated when one's liver is unable to remove bilirubin sufficiently from the blood. The conventional methods used for monitoring and measuring the bilirubin level are time consuming, tedious and invasive in nature. This study aims to investigate the feasibility o...

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Main Author:	Ong, Pek Ek
Format:	Thesis
Language:	English English English
Published:	2018
Subjects:	TK7800-8360 Electronics
Online Access:	http://eprints.uthm.edu.my/248/1/24p%20ONG%20PEK%20EK.pdf http://eprints.uthm.edu.my/248/2/ONG%20PEK%20EK%20COPYRIGHT%20DECLARATION.pdf http://eprints.uthm.edu.my/248/3/ONG%20PEK%20EK%20WATERMARK.pdf
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spelling	my-uthm-ep.2482021-07-14T01:40:12Z Reflectance spectroscopy system for real time and non-invasive detection of transcutaneous bilirubin level 2018-06 Ong, Pek Ek TK7800-8360 Electronics Blood bilirubin level would be elevated when one's liver is unable to remove bilirubin sufficiently from the blood. The conventional methods used for monitoring and measuring the bilirubin level are time consuming, tedious and invasive in nature. This study aims to investigate the feasibility of using Modified Lambeti Beer (MLB) A model in the prediction of one's bilirubin concentration using a priori knowledge of the extinction coefficient of bilirubin and haemoglobin components in the wavelength range of 400 500 nm. This study verified validity of the predicted value using light attenuation data from TracePro for a single-layered skin model with varying bilirubin concentration. The results revealed some promising trends in estimated bilirubin concentration and considerably good accuracy with percent mean relative error in the predicted bilirubin concentration, Cbil(p) calculated as 59.9 %. This study performed contact and non-contact experiments for the demonstration works. A total number of 60 individuals of different health status, skin tone and gender have been recruited for the contact experiment. Meanwhile, six healthy subjects was recruited for the noncontact experiment, and measurement was performed at various selected skin sites. From the contact experiment, this work found a lower skin bilirubin level in renal disease subjects compared to healthy subjects. In addition, a lower bilirubin was observed for individuals with dark skin compared to fair skin, and a higher bilirubin level in male compared to their female counterparts. Based on the experiments performed on healthy subjects using non-contact experiment arrangement, this work found that palm site has the lowest in the predicted mean transcutaneous bilirubin concentration with highest consistency given by 0.44±0.4 g/1 as compared to other skin sites. This study concluded that the developed system and strategy may be used as an alternative means to assess one's skin bilirubin level. 2018-06 Thesis http://eprints.uthm.edu.my/248/ http://eprints.uthm.edu.my/248/1/24p%20ONG%20PEK%20EK.pdf text en public http://eprints.uthm.edu.my/248/2/ONG%20PEK%20EK%20COPYRIGHT%20DECLARATION.pdf text en staffonly http://eprints.uthm.edu.my/248/3/ONG%20PEK%20EK%20WATERMARK.pdf text en validuser mphil masters Universiti Tun Hussein Onn Malaysia Faculty of Electrical and Electronic Engineering
institution	Universiti Tun Hussein Onn Malaysia
collection	UTHM Institutional Repository
language	English English English
topic	TK7800-8360 Electronics
spellingShingle	TK7800-8360 Electronics Ong, Pek Ek Reflectance spectroscopy system for real time and non-invasive detection of transcutaneous bilirubin level
description	Blood bilirubin level would be elevated when one's liver is unable to remove bilirubin sufficiently from the blood. The conventional methods used for monitoring and measuring the bilirubin level are time consuming, tedious and invasive in nature. This study aims to investigate the feasibility of using Modified Lambeti Beer (MLB) A model in the prediction of one's bilirubin concentration using a priori knowledge of the extinction coefficient of bilirubin and haemoglobin components in the wavelength range of 400 500 nm. This study verified validity of the predicted value using light attenuation data from TracePro for a single-layered skin model with varying bilirubin concentration. The results revealed some promising trends in estimated bilirubin concentration and considerably good accuracy with percent mean relative error in the predicted bilirubin concentration, Cbil(p) calculated as 59.9 %. This study performed contact and non-contact experiments for the demonstration works. A total number of 60 individuals of different health status, skin tone and gender have been recruited for the contact experiment. Meanwhile, six healthy subjects was recruited for the noncontact experiment, and measurement was performed at various selected skin sites. From the contact experiment, this work found a lower skin bilirubin level in renal disease subjects compared to healthy subjects. In addition, a lower bilirubin was observed for individuals with dark skin compared to fair skin, and a higher bilirubin level in male compared to their female counterparts. Based on the experiments performed on healthy subjects using non-contact experiment arrangement, this work found that palm site has the lowest in the predicted mean transcutaneous bilirubin concentration with highest consistency given by 0.44±0.4 g/1 as compared to other skin sites. This study concluded that the developed system and strategy may be used as an alternative means to assess one's skin bilirubin level.
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Ong, Pek Ek
author_facet	Ong, Pek Ek
author_sort	Ong, Pek Ek
title	Reflectance spectroscopy system for real time and non-invasive detection of transcutaneous bilirubin level
title_short	Reflectance spectroscopy system for real time and non-invasive detection of transcutaneous bilirubin level
title_full	Reflectance spectroscopy system for real time and non-invasive detection of transcutaneous bilirubin level
title_fullStr	Reflectance spectroscopy system for real time and non-invasive detection of transcutaneous bilirubin level
title_full_unstemmed	Reflectance spectroscopy system for real time and non-invasive detection of transcutaneous bilirubin level
title_sort	reflectance spectroscopy system for real time and non-invasive detection of transcutaneous bilirubin level
granting_institution	Universiti Tun Hussein Onn Malaysia
granting_department	Faculty of Electrical and Electronic Engineering
publishDate	2018
url	http://eprints.uthm.edu.my/248/1/24p%20ONG%20PEK%20EK.pdf http://eprints.uthm.edu.my/248/2/ONG%20PEK%20EK%20COPYRIGHT%20DECLARATION.pdf http://eprints.uthm.edu.my/248/3/ONG%20PEK%20EK%20WATERMARK.pdf
_version_	1747830564154507264

Reflectance spectroscopy system for real time and non-invasive detection of transcutaneous bilirubin level

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