Ethnobotanical and ethnopharmacological documentation of antimalarial plants used by the Jakun community in Kg Peta, Endau-Rompin, Johor, Malaysia

Malaria, one of the leading infectious diseases in many tropical regions including Malaysia is caused by the parasite Plasmodium. An ethnobotanical survey of medicinal plants used by the indigenous people particularly the Jakun tribe from Kg. Peta, Endau-Rompin, Johor for the treatment of malaria an...

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Main Author:	Ismail, Izdihar
Format:	Thesis
Language:	English English English
Published:	2017
Subjects:	RC Internal medicine
Online Access:	http://eprints.uthm.edu.my/788/3/24p%20IZDIHAR%20ISMAIL.pdf http://eprints.uthm.edu.my/788/1/IZDIHAR%20ISMAIL%20COPYRIGHT%20DECLARATION.pdf http://eprints.uthm.edu.my/788/2/IZDIHAR%20ISMAIL%20WATERMARK.pdf
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spelling	my-uthm-ep.7882021-08-30T08:03:05Z Ethnobotanical and ethnopharmacological documentation of antimalarial plants used by the Jakun community in Kg Peta, Endau-Rompin, Johor, Malaysia 2017-04 Ismail, Izdihar RC Internal medicine Malaria, one of the leading infectious diseases in many tropical regions including Malaysia is caused by the parasite Plasmodium. An ethnobotanical survey of medicinal plants used by the indigenous people particularly the Jakun tribe from Kg. Peta, Endau-Rompin, Johor for the treatment of malaria and malaria associated symptoms was conducted using a semi-structured interview. The declining popularity of application of traditional remedies by the young generation threatens the disappearance of traditional knowledge possessed mainly by the older generation. Hence, the need for documentation of this knowledge justifies the relevance of this study. Out of 19 species (17 families) were recorded, 7 species: Hodgsonia macrocarpa, Pentaphragma begoniifolium, Rennellia elliptica, Saprosma corymbosa, Strychnos ignatii, Tacca integrifolia and Tetracera macrophylla were investigated for phytochemical and in vitro antiplasmodial activities. Twelve aqueous and 12 methanolic extracts were screened for antiplasmodial phytochemical classes i.e., alkaloids, flavonoids, terpenoids and anthraquinones using thin-layer chromatography (TLC). Results revealed the presence of at least one of the phytochemical class in each extracts. Extracts were subjected to antiplasmodial activity through histidine-rich protein II (HRP2) assay against K1 strain of P. falciparum chloroquine-resistant. Overall, ten methanolic extracts from H. macrocarpa (stem), P. begoniifolium (root, stem and leaves), R. elliptica (root, stem and leaves), S. corymbosa (leaves), T. integrifolia (root) and T. macrophylla (stem) have potential antiplasmodial activities against chloroquine-resistant P. falciparum (IC50 < 10 μg/mL). The part of the plants species involves indicates statistically significant difference of IC50 between the kinds of extractions (p < 0.05). The results scientifically validated the plants used in Jakun’s traditional medicine displayed promising therapeutic properties and further studies could lead to develop phytomedicines in the treatment of malaria. 2017-04 Thesis http://eprints.uthm.edu.my/788/ http://eprints.uthm.edu.my/788/3/24p%20IZDIHAR%20ISMAIL.pdf text en public http://eprints.uthm.edu.my/788/1/IZDIHAR%20ISMAIL%20COPYRIGHT%20DECLARATION.pdf text en staffonly http://eprints.uthm.edu.my/788/2/IZDIHAR%20ISMAIL%20WATERMARK.pdf text en validuser mphil masters Universiti Tun Hussein Onn Malaysia Fakulti Sains Gunaan dan Teknologi
institution	Universiti Tun Hussein Onn Malaysia
collection	UTHM Institutional Repository
language	English English English
topic	RC Internal medicine
spellingShingle	RC Internal medicine Ismail, Izdihar Ethnobotanical and ethnopharmacological documentation of antimalarial plants used by the Jakun community in Kg Peta, Endau-Rompin, Johor, Malaysia
description	Malaria, one of the leading infectious diseases in many tropical regions including Malaysia is caused by the parasite Plasmodium. An ethnobotanical survey of medicinal plants used by the indigenous people particularly the Jakun tribe from Kg. Peta, Endau-Rompin, Johor for the treatment of malaria and malaria associated symptoms was conducted using a semi-structured interview. The declining popularity of application of traditional remedies by the young generation threatens the disappearance of traditional knowledge possessed mainly by the older generation. Hence, the need for documentation of this knowledge justifies the relevance of this study. Out of 19 species (17 families) were recorded, 7 species: Hodgsonia macrocarpa, Pentaphragma begoniifolium, Rennellia elliptica, Saprosma corymbosa, Strychnos ignatii, Tacca integrifolia and Tetracera macrophylla were investigated for phytochemical and in vitro antiplasmodial activities. Twelve aqueous and 12 methanolic extracts were screened for antiplasmodial phytochemical classes i.e., alkaloids, flavonoids, terpenoids and anthraquinones using thin-layer chromatography (TLC). Results revealed the presence of at least one of the phytochemical class in each extracts. Extracts were subjected to antiplasmodial activity through histidine-rich protein II (HRP2) assay against K1 strain of P. falciparum chloroquine-resistant. Overall, ten methanolic extracts from H. macrocarpa (stem), P. begoniifolium (root, stem and leaves), R. elliptica (root, stem and leaves), S. corymbosa (leaves), T. integrifolia (root) and T. macrophylla (stem) have potential antiplasmodial activities against chloroquine-resistant P. falciparum (IC50 < 10 μg/mL). The part of the plants species involves indicates statistically significant difference of IC50 between the kinds of extractions (p < 0.05). The results scientifically validated the plants used in Jakun’s traditional medicine displayed promising therapeutic properties and further studies could lead to develop phytomedicines in the treatment of malaria.
format	Thesis
qualification_name	Master of Philosophy (M.Phil.)
qualification_level	Master's degree
author	Ismail, Izdihar
author_facet	Ismail, Izdihar
author_sort	Ismail, Izdihar
title	Ethnobotanical and ethnopharmacological documentation of antimalarial plants used by the Jakun community in Kg Peta, Endau-Rompin, Johor, Malaysia
title_short	Ethnobotanical and ethnopharmacological documentation of antimalarial plants used by the Jakun community in Kg Peta, Endau-Rompin, Johor, Malaysia
title_full	Ethnobotanical and ethnopharmacological documentation of antimalarial plants used by the Jakun community in Kg Peta, Endau-Rompin, Johor, Malaysia
title_fullStr	Ethnobotanical and ethnopharmacological documentation of antimalarial plants used by the Jakun community in Kg Peta, Endau-Rompin, Johor, Malaysia
title_full_unstemmed	Ethnobotanical and ethnopharmacological documentation of antimalarial plants used by the Jakun community in Kg Peta, Endau-Rompin, Johor, Malaysia
title_sort	ethnobotanical and ethnopharmacological documentation of antimalarial plants used by the jakun community in kg peta, endau-rompin, johor, malaysia
granting_institution	Universiti Tun Hussein Onn Malaysia
granting_department	Fakulti Sains Gunaan dan Teknologi
publishDate	2017
url	http://eprints.uthm.edu.my/788/3/24p%20IZDIHAR%20ISMAIL.pdf http://eprints.uthm.edu.my/788/1/IZDIHAR%20ISMAIL%20COPYRIGHT%20DECLARATION.pdf http://eprints.uthm.edu.my/788/2/IZDIHAR%20ISMAIL%20WATERMARK.pdf
_version_	1747830681440878592

Ethnobotanical and ethnopharmacological documentation of antimalarial plants used by the Jakun community in Kg Peta, Endau-Rompin, Johor, Malaysia

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