Analysis of blood flow into the main artery via mitral valve

Mitral Valve failure causes death if it is not corrected surgically. Such surgical repair can be improved by understanding mitral biomechanics. A two-dimensional FSI model of the Mitral Valve was generated using the ADINA simulation. A simple approximation of the heart geometry was use, the valve di...

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Main Author:	Mohd. Adib, Mohd. Azrul Hisham
Format:	Thesis
Language:	English
Published:	2010
Subjects:	TJ Mechanical engineering and machinery
Online Access:	http://eprints.utm.my/id/eprint/11195/1/MohdAzrulHishamMFKM2010.pdf
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spelling	my-utm-ep.111952018-05-30T04:25:56Z Analysis of blood flow into the main artery via mitral valve 2010-04 Mohd. Adib, Mohd. Azrul Hisham TJ Mechanical engineering and machinery Mitral Valve failure causes death if it is not corrected surgically. Such surgical repair can be improved by understanding mitral biomechanics. A two-dimensional FSI model of the Mitral Valve was generated using the ADINA simulation. A simple approximation of the heart geometry was use, the valve dimensions were based on measurements made. The viscosity of blood and the elastic properties of the valve leaflets were obtained from the literature. In this study, numerical modeling was used to determine the correlation between the degeneration of the Mitral Valves rigidity and backflow problem based on several critical parameters of blood. Two stages of Mitral Valve simulation, systolic and diastolic stage and also with ventricle and without ventricle are investigated. Finally, conclude that rigidity of Mitral Valve antipodes to the backflow and Degeneration causing backflow will reach a constant value and agreed with results from experimental. 2010-04 Thesis http://eprints.utm.my/id/eprint/11195/ http://eprints.utm.my/id/eprint/11195/1/MohdAzrulHishamMFKM2010.pdf application/pdf en public masters Universiti Teknologi Malaysia, Faculty of Mechanical Engineering Faculty of Mechanical Engineering [1] Daniel M. Espino, Michael A. Watkins, Duncan E.T. Shepherd, David W.L. Hukins and Keith G. Buchan. “Simulation of Blood Flow through the Mitral Valve of the Heart: A Fluid Structure Interaction Model”. Department of Mechanical and Manufacturing Engineering, University of Birmingham, Birmingham, UK, 2006. [2] K. S. Kunzelman1, D. R. Einstein and R. P. Cochran, “Fluid–structure interaction models of the mitral valve: function in normal and pathological states”, Central Maine Medical Center, 60 High Street, Lewiston, ME 04210, USA. Pacific Northwest National Laboratory, Richland, WA 99352, USA, 2007. [3] Espino et al, “Determination of the pressure required to cause mitral valve failure”, Medical Engineering and Physics, 28, 36-41. 2006. [4] Ali Mirnajafi, Jeremy M. Raymera, Leigh R. McClurea, Michael S. Sacksa, “The flexural rigidity of the aortic valve leaflet in the commissural region”. Engineered Tissue Mechanics Laboratory, Department of Bioengineering, University of Pittsburgh, 100 Technology drive, Room 234, Pittsburgh, PA 15219, USA. McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA, 2005. [5] Dhanjoo N. Ghista , Anant P. Rao. “Mitral-valve mechanics--stress/strain characteristics of excised leaflets, analysis of its functional mechanics and its medical application”. Biomechanics Division, Indian Institute of Technology, Madras-36, India and School of Engineering, University of Colorado, Fort Collins, Colorado USA, 1995. [6] Reul et al, “Fluid mechanics of the natural mitral valve”, Journal of Biomechanics, 14, 361-372, 1980. [7] Watton et al, “Dynamic modelling of prosthetic chorded mitral valves using the immersed boundary method” , Journal of Biomechanics, In Press, 2006. [8] Roland Fasol, MD, Johann Meinhart, PhD, Manfred Deutsch, MD, and Thomas Binder, MD. “Mitral Valve Repair With the Colvin-Galloway Future Band” Department of Cardiovascular Surgery, Hospital Lainz, and Department of Cardiology, AKH, University of Vienna, Vienna, Austria, 2004. [9] Einstein et al, “The relationship of normal and abnormal microstructural proliferation to the mitral valve closure sound”, Journal of Biomechanical Engineering, 127, 134-147, 2005. [10] Espino et al, “Mitral valve repair: an in vitro comparison of the effect of surgical repair on the pressure required to cause mitral valve regurgitation”, Journal of Heart Valve Disease, 15, 375-381, 2006.
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	TJ Mechanical engineering and machinery
spellingShingle	TJ Mechanical engineering and machinery Mohd. Adib, Mohd. Azrul Hisham Analysis of blood flow into the main artery via mitral valve
description	Mitral Valve failure causes death if it is not corrected surgically. Such surgical repair can be improved by understanding mitral biomechanics. A two-dimensional FSI model of the Mitral Valve was generated using the ADINA simulation. A simple approximation of the heart geometry was use, the valve dimensions were based on measurements made. The viscosity of blood and the elastic properties of the valve leaflets were obtained from the literature. In this study, numerical modeling was used to determine the correlation between the degeneration of the Mitral Valves rigidity and backflow problem based on several critical parameters of blood. Two stages of Mitral Valve simulation, systolic and diastolic stage and also with ventricle and without ventricle are investigated. Finally, conclude that rigidity of Mitral Valve antipodes to the backflow and Degeneration causing backflow will reach a constant value and agreed with results from experimental.
format	Thesis
qualification_level	Master's degree
author	Mohd. Adib, Mohd. Azrul Hisham
author_facet	Mohd. Adib, Mohd. Azrul Hisham
author_sort	Mohd. Adib, Mohd. Azrul Hisham
title	Analysis of blood flow into the main artery via mitral valve
title_short	Analysis of blood flow into the main artery via mitral valve
title_full	Analysis of blood flow into the main artery via mitral valve
title_fullStr	Analysis of blood flow into the main artery via mitral valve
title_full_unstemmed	Analysis of blood flow into the main artery via mitral valve
title_sort	analysis of blood flow into the main artery via mitral valve
granting_institution	Universiti Teknologi Malaysia, Faculty of Mechanical Engineering
granting_department	Faculty of Mechanical Engineering
publishDate	2010
url	http://eprints.utm.my/id/eprint/11195/1/MohdAzrulHishamMFKM2010.pdf
_version_	1747814823973879808

Analysis of blood flow into the main artery via mitral valve

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