Synthesis of hydroxylated and prenylated chalcones

Prenylated chalcones are among the compounds found in local Artocarpus species which reported to have interesting biological activities. Moreover, prenylated chalcones are used as traditional folk medicine for the treatment of inflammation, malarial fever and to treat the ulcers and diarrhea. In thi...

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Main Author:	Hasan, Aso Hameed
Format:	Thesis
Language:	English
Published:	2013
Subjects:	Q Science (General)
Online Access:	http://eprints.utm.my/id/eprint/39737/5/AsoHameedHasanMFS2013.pdf
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id	my-utm-ep.39737
record_format	uketd_dc
spelling	my-utm-ep.397372017-07-13T06:48:04Z Synthesis of hydroxylated and prenylated chalcones 2013-06 Hasan, Aso Hameed Q Science (General) Prenylated chalcones are among the compounds found in local Artocarpus species which reported to have interesting biological activities. Moreover, prenylated chalcones are used as traditional folk medicine for the treatment of inflammation, malarial fever and to treat the ulcers and diarrhea. In this study, 2,4-dihydroxy-3-C-prenylacetophenone and 2,4-dihydroxy-5-C-prenylacetophenone were successfully synthesized by treating resacetophenone with 2-methylbut-3-en-2-ol in the presence of BF3.Et2O as the catalyst. Meanwhile 2,4,6-trihydroxy-3-C-prenylacetophenone was synthesized using K2CO3 as the catalyst in dry acetone in the reaction of prenyl bromide with 2,4,6-trihydroxyacetophenone . In addition, two hydroxylated chalcone namely 2',4',4-trihydroxychalcone , 4',4-dihydroxychalcone) together with 2',4',4,6'-tetrahydroxy-3'-prenylchalcone were synthesized by Claisen-Schmidt condensation of various hydroxyacetophenone and 2,4,6-trihydroxy-3-C-prenylacetophenone for prenylated chalcone with 4-hydroxybenzaldyhe using BF3.Et2O. The structures of all compounds were characterized using spectroscopic methods (NMR and IR). 2013-06 Thesis http://eprints.utm.my/id/eprint/39737/ http://eprints.utm.my/id/eprint/39737/5/AsoHameedHasanMFS2013.pdf application/pdf en public masters Universiti Teknologi Malaysia, Faculty of Science Faculty of Science
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	Q Science (General)
spellingShingle	Q Science (General) Hasan, Aso Hameed Synthesis of hydroxylated and prenylated chalcones
description	Prenylated chalcones are among the compounds found in local Artocarpus species which reported to have interesting biological activities. Moreover, prenylated chalcones are used as traditional folk medicine for the treatment of inflammation, malarial fever and to treat the ulcers and diarrhea. In this study, 2,4-dihydroxy-3-C-prenylacetophenone and 2,4-dihydroxy-5-C-prenylacetophenone were successfully synthesized by treating resacetophenone with 2-methylbut-3-en-2-ol in the presence of BF3.Et2O as the catalyst. Meanwhile 2,4,6-trihydroxy-3-C-prenylacetophenone was synthesized using K2CO3 as the catalyst in dry acetone in the reaction of prenyl bromide with 2,4,6-trihydroxyacetophenone . In addition, two hydroxylated chalcone namely 2',4',4-trihydroxychalcone , 4',4-dihydroxychalcone) together with 2',4',4,6'-tetrahydroxy-3'-prenylchalcone were synthesized by Claisen-Schmidt condensation of various hydroxyacetophenone and 2,4,6-trihydroxy-3-C-prenylacetophenone for prenylated chalcone with 4-hydroxybenzaldyhe using BF3.Et2O. The structures of all compounds were characterized using spectroscopic methods (NMR and IR).
format	Thesis
qualification_level	Master's degree
author	Hasan, Aso Hameed
author_facet	Hasan, Aso Hameed
author_sort	Hasan, Aso Hameed
title	Synthesis of hydroxylated and prenylated chalcones
title_short	Synthesis of hydroxylated and prenylated chalcones
title_full	Synthesis of hydroxylated and prenylated chalcones
title_fullStr	Synthesis of hydroxylated and prenylated chalcones
title_full_unstemmed	Synthesis of hydroxylated and prenylated chalcones
title_sort	synthesis of hydroxylated and prenylated chalcones
granting_institution	Universiti Teknologi Malaysia, Faculty of Science
granting_department	Faculty of Science
publishDate	2013
url	http://eprints.utm.my/id/eprint/39737/5/AsoHameedHasanMFS2013.pdf
_version_	1747816544395591680

Synthesis of hydroxylated and prenylated chalcones

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