Formulation and characterization of ginger-loaded niosome

Ginger oil is well known for its potential as a bioactive phytochemical and long history of medicinal use with antioxidant, anti-obesity and cancer preventive activity. Although many herbal drugs have potential to promote health in vitro findings they have shown less or no in vivo actions due to the...

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Main Author:	Bagheri, Ali
Format:	Thesis
Language:	English
Published:	2013
Subjects:	QK Botany
Online Access:	http://eprints.utm.my/id/eprint/42128/1/AliBagheriMFKK2013.pdf
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id	my-utm-ep.42128
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spelling	my-utm-ep.421282017-07-10T07:32:05Z Formulation and characterization of ginger-loaded niosome 2013 Bagheri, Ali QK Botany Ginger oil is well known for its potential as a bioactive phytochemical and long history of medicinal use with antioxidant, anti-obesity and cancer preventive activity. Although many herbal drugs have potential to promote health in vitro findings they have shown less or no in vivo actions due to their poor solubility or improper molecular size or both, ultimately resulting in poor bioavailability and poor absorption which are the major limiting factors of development herbal drugs. Niosome as a lipid-based carrier system with remarkable advantages over conventional drug delivery systems was used as a carrier in this study in order to get the benefits of both herb and carrier. Therefore, the main objective of this study was to formulate the ginger oil-loaded niosome. Firstly, pre-formulation studies were carried out in order to investigate the feasibility of encapsulation ginger oil as a lipophilic active compound. All niosome formulations were prepared by the film hydration method and characterized for drug entrapment efficiency (EE) and particle size (PS). Niosome formulations were optimized with using Response Surface Methodology (RSM) based on Central Composite Design (CCRD). Interaction of two formulation variables, namely amount of Span 60 (x1) and Labrasol (x2) which have great influence on particle size and entrapment efficiency were studied. Labrasol was determined as a key factor responsible for entrapment efficiency which increasing concentration of Labrasol from 0.45 (mM) to 2.5 (mM) has decreased around 10 % of entrapped drug. In conclusion, the niosomes were successfully able to encapsulate ginger oil with high entrapment efficiency which can be useful in developing more effective use of ginger oil for human health. 2013 Thesis http://eprints.utm.my/id/eprint/42128/ http://eprints.utm.my/id/eprint/42128/1/AliBagheriMFKK2013.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:73523?queryType=vitalDismax&query=Formulation+and+characterization+of+ginger-loaded+niosome&public=true masters Universiti Teknologi Malaysia, Faculty of Chemical Engineering Faculty of Chemical Engineering
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	QK Botany
spellingShingle	QK Botany Bagheri, Ali Formulation and characterization of ginger-loaded niosome
description	Ginger oil is well known for its potential as a bioactive phytochemical and long history of medicinal use with antioxidant, anti-obesity and cancer preventive activity. Although many herbal drugs have potential to promote health in vitro findings they have shown less or no in vivo actions due to their poor solubility or improper molecular size or both, ultimately resulting in poor bioavailability and poor absorption which are the major limiting factors of development herbal drugs. Niosome as a lipid-based carrier system with remarkable advantages over conventional drug delivery systems was used as a carrier in this study in order to get the benefits of both herb and carrier. Therefore, the main objective of this study was to formulate the ginger oil-loaded niosome. Firstly, pre-formulation studies were carried out in order to investigate the feasibility of encapsulation ginger oil as a lipophilic active compound. All niosome formulations were prepared by the film hydration method and characterized for drug entrapment efficiency (EE) and particle size (PS). Niosome formulations were optimized with using Response Surface Methodology (RSM) based on Central Composite Design (CCRD). Interaction of two formulation variables, namely amount of Span 60 (x1) and Labrasol (x2) which have great influence on particle size and entrapment efficiency were studied. Labrasol was determined as a key factor responsible for entrapment efficiency which increasing concentration of Labrasol from 0.45 (mM) to 2.5 (mM) has decreased around 10 % of entrapped drug. In conclusion, the niosomes were successfully able to encapsulate ginger oil with high entrapment efficiency which can be useful in developing more effective use of ginger oil for human health.
format	Thesis
qualification_level	Master's degree
author	Bagheri, Ali
author_facet	Bagheri, Ali
author_sort	Bagheri, Ali
title	Formulation and characterization of ginger-loaded niosome
title_short	Formulation and characterization of ginger-loaded niosome
title_full	Formulation and characterization of ginger-loaded niosome
title_fullStr	Formulation and characterization of ginger-loaded niosome
title_full_unstemmed	Formulation and characterization of ginger-loaded niosome
title_sort	formulation and characterization of ginger-loaded niosome
granting_institution	Universiti Teknologi Malaysia, Faculty of Chemical Engineering
granting_department	Faculty of Chemical Engineering
publishDate	2013
url	http://eprints.utm.my/id/eprint/42128/1/AliBagheriMFKK2013.pdf
_version_	1747816696574377984

Formulation and characterization of ginger-loaded niosome

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