Improvement of haemodynamic stent strut configuration for patent ductus arteriosus through computational modelling

Currently, the treatment of Patent Ductus Arteriosus (PDA) by the implantation of coronary stent has resulted in severe hemodynamic complications. There is thus a need to customize and improve current stent geometry specific to PDA to overcome this problem. Computational Fluid Dynamics (CFD) approac...

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Main Author:	Taib, Ishkrizat
Format:	Thesis
Language:	English
Published:	2016
Subjects:	TJ Mechanical engineering and machinery
Online Access:	http://eprints.utm.my/id/eprint/78085/1/IshkrizatTaibPFKM2016.pdf
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id	my-utm-ep.78085
record_format	uketd_dc
spelling	my-utm-ep.780852018-07-23T06:10:21Z Improvement of haemodynamic stent strut configuration for patent ductus arteriosus through computational modelling 2016-01 Taib, Ishkrizat TJ Mechanical engineering and machinery Currently, the treatment of Patent Ductus Arteriosus (PDA) by the implantation of coronary stent has resulted in severe hemodynamic complications. There is thus a need to customize and improve current stent geometry specific to PDA to overcome this problem. Computational Fluid Dynamics (CFD) approaches, verified by an experimental technique are used to analyze current stent strut configurations. Statistical analysis is used to rank the parameter performance and to obtain the best stent configuration. The most favorable configuration is then used to design new stent strut configuration specific for PDA. In the analysis of the new stent design, CFD results show low possibility of re-stenosis process due to thrombosis formation, inflammation, and neo-intimal hyperplasia. Furthermore, comprehensive CFD analysis by solving fluid-structure interaction (FSI) cases has produced an optimum stent strut configuration that is structurally sound. The strength of stent strut configuration due to hemodynamic effect is analyzed through the Von Misses stress distribution. The results show that the new improved design of stent strut configuration has excellent hemodynamic performance. Finally, the new stent design is predicted to be able to overcome hemodynamic complications and stent structural failure when applied specifically to PDA. 2016-01 Thesis http://eprints.utm.my/id/eprint/78085/ http://eprints.utm.my/id/eprint/78085/1/IshkrizatTaibPFKM2016.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:97585 phd doctoral Universiti Teknologi Malaysia, Faculty of Mechanical Engineering Faculty of Mechanical Engineering
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	TJ Mechanical engineering and machinery
spellingShingle	TJ Mechanical engineering and machinery Taib, Ishkrizat Improvement of haemodynamic stent strut configuration for patent ductus arteriosus through computational modelling
description	Currently, the treatment of Patent Ductus Arteriosus (PDA) by the implantation of coronary stent has resulted in severe hemodynamic complications. There is thus a need to customize and improve current stent geometry specific to PDA to overcome this problem. Computational Fluid Dynamics (CFD) approaches, verified by an experimental technique are used to analyze current stent strut configurations. Statistical analysis is used to rank the parameter performance and to obtain the best stent configuration. The most favorable configuration is then used to design new stent strut configuration specific for PDA. In the analysis of the new stent design, CFD results show low possibility of re-stenosis process due to thrombosis formation, inflammation, and neo-intimal hyperplasia. Furthermore, comprehensive CFD analysis by solving fluid-structure interaction (FSI) cases has produced an optimum stent strut configuration that is structurally sound. The strength of stent strut configuration due to hemodynamic effect is analyzed through the Von Misses stress distribution. The results show that the new improved design of stent strut configuration has excellent hemodynamic performance. Finally, the new stent design is predicted to be able to overcome hemodynamic complications and stent structural failure when applied specifically to PDA.
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Taib, Ishkrizat
author_facet	Taib, Ishkrizat
author_sort	Taib, Ishkrizat
title	Improvement of haemodynamic stent strut configuration for patent ductus arteriosus through computational modelling
title_short	Improvement of haemodynamic stent strut configuration for patent ductus arteriosus through computational modelling
title_full	Improvement of haemodynamic stent strut configuration for patent ductus arteriosus through computational modelling
title_fullStr	Improvement of haemodynamic stent strut configuration for patent ductus arteriosus through computational modelling
title_full_unstemmed	Improvement of haemodynamic stent strut configuration for patent ductus arteriosus through computational modelling
title_sort	improvement of haemodynamic stent strut configuration for patent ductus arteriosus through computational modelling
granting_institution	Universiti Teknologi Malaysia, Faculty of Mechanical Engineering
granting_department	Faculty of Mechanical Engineering
publishDate	2016
url	http://eprints.utm.my/id/eprint/78085/1/IshkrizatTaibPFKM2016.pdf
_version_	1747817903318630400

Improvement of haemodynamic stent strut configuration for patent ductus arteriosus through computational modelling

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