Preparation, characterization and biocompatibility evaluation of poly(diol citrate) blend polyethersulfone hemodialysis membranes

Hemodialysis is one of the applied membrane technologies that is regarded as a life-saving therapy for patients with impaired kidneys. It purifies blood toxins outside of the patient’s body using a dialyzer as a kidney replacement. Synthetic materials such as polyethersulfone (PES) polymer are curre...

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Main Author:	Zailani, Muhamad Zulhilmi
Format:	Thesis
Language:	English
Published:	2017
Subjects:	TP Chemical technology
Online Access:	http://eprints.utm.my/id/eprint/78234/1/MuhamadZulhilmiZailaniMFChE2017.pdf
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spelling	my-utm-ep.782342018-07-30T08:51:31Z Preparation, characterization and biocompatibility evaluation of poly(diol citrate) blend polyethersulfone hemodialysis membranes 2017-01 Zailani, Muhamad Zulhilmi TP Chemical technology Hemodialysis is one of the applied membrane technologies that is regarded as a life-saving therapy for patients with impaired kidneys. It purifies blood toxins outside of the patient’s body using a dialyzer as a kidney replacement. Synthetic materials such as polyethersulfone (PES) polymer are currently being used to fabricate the dialyzer membrane for hemodialysis. However, the blood compatibility or hemocompatibility of these materials are still inadequate and administration of an anticoagulant (heparin) is required throughout the dialysis procedure to avoid blood clotting. Therefore this study aimed at developing a biocompatibility membrane for hemodialysis application. In this study, poly (1,8-octanediol citrate) (POC) that synthesized through a simple polycondesation method was used to enhance membrane biocompatibility. Different compositions of POC (0-3%) were added into polyethersulfone (PES) dope solutions to fabricate modified biocompatible PES membranes via the phase-inversion technique. The biocompatibility of the modified PES membranes was evaluated by human serum fibrinogen (FBG) protein adsorption, platelet adhesion, activated partial thromboplastin time (APTT) and prothrombin time (PT), thrombin–antithrombin III (TAT), complement (C3a and C5a) activation and Ca2+ absorption on membrane. Results showed that higher POC wt.% caused a 31% reduction of FBG adsorption, less platelets adhesion, prolonged APTT (11.1 seconds) and PT (2.5 seconds), lower TAT activation, suppressed C5a and C3a activation and absorbed 35% more Ca2+ ion compared to pristine PES membrane. These results indicated that modified PES blended POC has good biocompatibility properties, suggesting potential application in the field of blood purification, especially in hemodialysis. 2017-01 Thesis http://eprints.utm.my/id/eprint/78234/ http://eprints.utm.my/id/eprint/78234/1/MuhamadZulhilmiZailaniMFChE2017.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:105050 masters Universiti Teknologi Malaysia, Faculty of Chemical Engineering Faculty of Chemical Engineering
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Zailani, Muhamad Zulhilmi Preparation, characterization and biocompatibility evaluation of poly(diol citrate) blend polyethersulfone hemodialysis membranes
description	Hemodialysis is one of the applied membrane technologies that is regarded as a life-saving therapy for patients with impaired kidneys. It purifies blood toxins outside of the patient’s body using a dialyzer as a kidney replacement. Synthetic materials such as polyethersulfone (PES) polymer are currently being used to fabricate the dialyzer membrane for hemodialysis. However, the blood compatibility or hemocompatibility of these materials are still inadequate and administration of an anticoagulant (heparin) is required throughout the dialysis procedure to avoid blood clotting. Therefore this study aimed at developing a biocompatibility membrane for hemodialysis application. In this study, poly (1,8-octanediol citrate) (POC) that synthesized through a simple polycondesation method was used to enhance membrane biocompatibility. Different compositions of POC (0-3%) were added into polyethersulfone (PES) dope solutions to fabricate modified biocompatible PES membranes via the phase-inversion technique. The biocompatibility of the modified PES membranes was evaluated by human serum fibrinogen (FBG) protein adsorption, platelet adhesion, activated partial thromboplastin time (APTT) and prothrombin time (PT), thrombin–antithrombin III (TAT), complement (C3a and C5a) activation and Ca2+ absorption on membrane. Results showed that higher POC wt.% caused a 31% reduction of FBG adsorption, less platelets adhesion, prolonged APTT (11.1 seconds) and PT (2.5 seconds), lower TAT activation, suppressed C5a and C3a activation and absorbed 35% more Ca2+ ion compared to pristine PES membrane. These results indicated that modified PES blended POC has good biocompatibility properties, suggesting potential application in the field of blood purification, especially in hemodialysis.
format	Thesis
qualification_level	Master's degree
author	Zailani, Muhamad Zulhilmi
author_facet	Zailani, Muhamad Zulhilmi
author_sort	Zailani, Muhamad Zulhilmi
title	Preparation, characterization and biocompatibility evaluation of poly(diol citrate) blend polyethersulfone hemodialysis membranes
title_short	Preparation, characterization and biocompatibility evaluation of poly(diol citrate) blend polyethersulfone hemodialysis membranes
title_full	Preparation, characterization and biocompatibility evaluation of poly(diol citrate) blend polyethersulfone hemodialysis membranes
title_fullStr	Preparation, characterization and biocompatibility evaluation of poly(diol citrate) blend polyethersulfone hemodialysis membranes
title_full_unstemmed	Preparation, characterization and biocompatibility evaluation of poly(diol citrate) blend polyethersulfone hemodialysis membranes
title_sort	preparation, characterization and biocompatibility evaluation of poly(diol citrate) blend polyethersulfone hemodialysis membranes
granting_institution	Universiti Teknologi Malaysia, Faculty of Chemical Engineering
granting_department	Faculty of Chemical Engineering
publishDate	2017
url	http://eprints.utm.my/id/eprint/78234/1/MuhamadZulhilmiZailaniMFChE2017.pdf
_version_	1747817939889815552

Preparation, characterization and biocompatibility evaluation of poly(diol citrate) blend polyethersulfone hemodialysis membranes

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