Anti-tyrosinase and cytotoxic activities of synthetic compound 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone

It has been demonstrated by several studies that synthetic chalcone compound products having antioxidant and anti tyrosinase properties. In this study, the novel synthetic 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone (HTMC) was evaluated for their antityrosinase, antioxidant, and cytotoxicity propertie...

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Main Author:	Ahmad, Nor Azlina
Format:	Thesis
Language:	English
Published:	2012
Subjects:	TP Chemical technology
Online Access:	http://eprints.utm.my/id/eprint/78309/1/NorAzlinaAhmadMFBB20121.pdf
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spelling	my-utm-ep.783092018-08-20T07:25:27Z Anti-tyrosinase and cytotoxic activities of synthetic compound 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone 2012 Ahmad, Nor Azlina TP Chemical technology It has been demonstrated by several studies that synthetic chalcone compound products having antioxidant and anti tyrosinase properties. In this study, the novel synthetic 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone (HTMC) was evaluated for their antityrosinase, antioxidant, and cytotoxicity properties. In anti tyrosinase activities, HTMC showed an activity and is postulated as potential tyrosinase inhibitor. The antityrosinase activity of HTMC, however, was lower than Kojic Acid (positive control). It was due to the structure of HTMC that have been modified synthetically at position 4 by inserting methoxy group. For that reason, the potency of HTMC as tyrosinase inhibitor was reduced and this statement supports our finding that is HTMC have less active compared to kojic acid. In contrast, HTMC demonstrate low antioxidant activities for both DPPH and FRAP assays. The highest percentage of inhibition for HTMC was 37% in DPPH assay at the concentration of 242 μM whilst the highest FRAP value of HTMC was 2 351 μmol/L. It is due to their chemical structure that contains only 1 group of hydroxyl in A-ring at position 2 that reflected to its ability to scavenge free radicals. HTMC showed negligible toxicity effect on Chinese Hamster Ovary (CHO) cell at the concentration of (0, 0.01, 0.1 and 1) μM. As it considered as preliminary report on cytotoxicity effect of HTMC, this data is valuable to be further investigated on human cell line. 2012 Thesis http://eprints.utm.my/id/eprint/78309/ http://eprints.utm.my/id/eprint/78309/1/NorAzlinaAhmadMFBB20121.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:82609 masters Universiti Teknologi Malaysia, Faculty of Biosciences and Medical Engineering Faculty of Biosciences and Medical Engineering
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Ahmad, Nor Azlina Anti-tyrosinase and cytotoxic activities of synthetic compound 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone
description	It has been demonstrated by several studies that synthetic chalcone compound products having antioxidant and anti tyrosinase properties. In this study, the novel synthetic 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone (HTMC) was evaluated for their antityrosinase, antioxidant, and cytotoxicity properties. In anti tyrosinase activities, HTMC showed an activity and is postulated as potential tyrosinase inhibitor. The antityrosinase activity of HTMC, however, was lower than Kojic Acid (positive control). It was due to the structure of HTMC that have been modified synthetically at position 4 by inserting methoxy group. For that reason, the potency of HTMC as tyrosinase inhibitor was reduced and this statement supports our finding that is HTMC have less active compared to kojic acid. In contrast, HTMC demonstrate low antioxidant activities for both DPPH and FRAP assays. The highest percentage of inhibition for HTMC was 37% in DPPH assay at the concentration of 242 μM whilst the highest FRAP value of HTMC was 2 351 μmol/L. It is due to their chemical structure that contains only 1 group of hydroxyl in A-ring at position 2 that reflected to its ability to scavenge free radicals. HTMC showed negligible toxicity effect on Chinese Hamster Ovary (CHO) cell at the concentration of (0, 0.01, 0.1 and 1) μM. As it considered as preliminary report on cytotoxicity effect of HTMC, this data is valuable to be further investigated on human cell line.
format	Thesis
qualification_level	Master's degree
author	Ahmad, Nor Azlina
author_facet	Ahmad, Nor Azlina
author_sort	Ahmad, Nor Azlina
title	Anti-tyrosinase and cytotoxic activities of synthetic compound 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone
title_short	Anti-tyrosinase and cytotoxic activities of synthetic compound 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone
title_full	Anti-tyrosinase and cytotoxic activities of synthetic compound 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone
title_fullStr	Anti-tyrosinase and cytotoxic activities of synthetic compound 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone
title_full_unstemmed	Anti-tyrosinase and cytotoxic activities of synthetic compound 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone
title_sort	anti-tyrosinase and cytotoxic activities of synthetic compound 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone
granting_institution	Universiti Teknologi Malaysia, Faculty of Biosciences and Medical Engineering
granting_department	Faculty of Biosciences and Medical Engineering
publishDate	2012
url	http://eprints.utm.my/id/eprint/78309/1/NorAzlinaAhmadMFBB20121.pdf
_version_	1747817957758599168

Anti-tyrosinase and cytotoxic activities of synthetic compound 2’-hydroxy-3,4,3’,4’-tetramethoxychalcone

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