Interfacial wicking flow through hierarchical structure of natural cellulose fibers for biomedical microfluidic devices

Micro/Nanofluidics technology is a new research area focused on analyzing and controlling flow of fluids and bio-particles at nanometer and micrometer scales. In an attempt to achieve low cost fabrication and operation of microfluidic devices, the use of cotton fabric was proposed as a new platform...

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Main Author:	Sadir, Sahba
Format:	Thesis
Language:	English
Published:	2015
Subjects:	TJ Mechanical engineering and machinery
Online Access:	http://eprints.utm.my/id/eprint/78509/1/SahbaSadirMFKM2015.pdf
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spelling	my-utm-ep.785092018-08-26T11:58:25Z Interfacial wicking flow through hierarchical structure of natural cellulose fibers for biomedical microfluidic devices 2015-11 Sadir, Sahba TJ Mechanical engineering and machinery Micro/Nanofluidics technology is a new research area focused on analyzing and controlling flow of fluids and bio-particles at nanometer and micrometer scales. In an attempt to achieve low cost fabrication and operation of microfluidic devices, the use of cotton fabric was proposed as a new platform for developing low-cost microfluidic devices. This thesis presents a novel wicking fluidic study through the hierarchical structures of textiles by multi-stage analysis of fluid flow at different structural scales, from the macro- (the three dimensional network structure of the cotton fabrics), via the micro- (the tiny segment of the textile structure, twisted multi fibers in a yarn) to the nanoscale (single fiber). The wicking flow within the cotton fabric structure and kapok fiber (as a hollow fiber and a simple model for the wicking flow) was experimentally analyzed using quantitative fluorescence microscopy data from the motion of fluorescent beads. Thereafter, in order to formulate the wicking flow through the hierarchical structure of the fibers network of the cotton fabrics and to predict how the wicking flow depends on the textile structure and basic material properties, experimental analyses based on fluorescent beads tracing with fluorescent and confocal microscopy as well as analytical analyses were carried out. The results of this study formed the foundation of new theories and novel ideas for interfacing microfluidics and nanofluidics. Additionally, the analyses prove that the wicking and the capillary action play important roles in selective mass transport in the textile structures. This phenomenon is potentially useful for biological and chemical detection in biosensors devices. The research targets application in novel passive size-based mechanical cell sorting using cotton fabric chip and fiber based enzyme-linked immunosorbent assay (ELISA). 2015-11 Thesis http://eprints.utm.my/id/eprint/78509/ http://eprints.utm.my/id/eprint/78509/1/SahbaSadirMFKM2015.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:95642 phd doctoral Universiti Teknologi Malaysia, Faculty of Mechanical Engineering Faculty of Mechanical Engineering
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	TJ Mechanical engineering and machinery
spellingShingle	TJ Mechanical engineering and machinery Sadir, Sahba Interfacial wicking flow through hierarchical structure of natural cellulose fibers for biomedical microfluidic devices
description	Micro/Nanofluidics technology is a new research area focused on analyzing and controlling flow of fluids and bio-particles at nanometer and micrometer scales. In an attempt to achieve low cost fabrication and operation of microfluidic devices, the use of cotton fabric was proposed as a new platform for developing low-cost microfluidic devices. This thesis presents a novel wicking fluidic study through the hierarchical structures of textiles by multi-stage analysis of fluid flow at different structural scales, from the macro- (the three dimensional network structure of the cotton fabrics), via the micro- (the tiny segment of the textile structure, twisted multi fibers in a yarn) to the nanoscale (single fiber). The wicking flow within the cotton fabric structure and kapok fiber (as a hollow fiber and a simple model for the wicking flow) was experimentally analyzed using quantitative fluorescence microscopy data from the motion of fluorescent beads. Thereafter, in order to formulate the wicking flow through the hierarchical structure of the fibers network of the cotton fabrics and to predict how the wicking flow depends on the textile structure and basic material properties, experimental analyses based on fluorescent beads tracing with fluorescent and confocal microscopy as well as analytical analyses were carried out. The results of this study formed the foundation of new theories and novel ideas for interfacing microfluidics and nanofluidics. Additionally, the analyses prove that the wicking and the capillary action play important roles in selective mass transport in the textile structures. This phenomenon is potentially useful for biological and chemical detection in biosensors devices. The research targets application in novel passive size-based mechanical cell sorting using cotton fabric chip and fiber based enzyme-linked immunosorbent assay (ELISA).
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Sadir, Sahba
author_facet	Sadir, Sahba
author_sort	Sadir, Sahba
title	Interfacial wicking flow through hierarchical structure of natural cellulose fibers for biomedical microfluidic devices
title_short	Interfacial wicking flow through hierarchical structure of natural cellulose fibers for biomedical microfluidic devices
title_full	Interfacial wicking flow through hierarchical structure of natural cellulose fibers for biomedical microfluidic devices
title_fullStr	Interfacial wicking flow through hierarchical structure of natural cellulose fibers for biomedical microfluidic devices
title_full_unstemmed	Interfacial wicking flow through hierarchical structure of natural cellulose fibers for biomedical microfluidic devices
title_sort	interfacial wicking flow through hierarchical structure of natural cellulose fibers for biomedical microfluidic devices
granting_institution	Universiti Teknologi Malaysia, Faculty of Mechanical Engineering
granting_department	Faculty of Mechanical Engineering
publishDate	2015
url	http://eprints.utm.my/id/eprint/78509/1/SahbaSadirMFKM2015.pdf
_version_	1747818002421645312

Interfacial wicking flow through hierarchical structure of natural cellulose fibers for biomedical microfluidic devices

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