Alzheimer disease biomarker based on carotid artery reactivity

Alzheimer disease biomarker based on carotid artery reactivity

Alzheimer disease (AD) is a progressive neurodegenerative disorder associated with the disruption of neuronal function. Carotid Artery Reactivity (CAR) is a new biomarker method for AD detection which provides various advantages as compared to existing detection method. Current developed methods hav...

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Main Author: Jamlos, Mohd. Aminudin
Format: Thesis
Language:English
Published: 2012
Subjects:
QH301 Biology
Online Access:http://eprints.utm.my/id/eprint/78827/1/MohdAminudinJamlosMFBME2012.pdf
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spelling my-utm-ep.788272018-09-17T04:20:56Z Alzheimer disease biomarker based on carotid artery reactivity 2012-09 Jamlos, Mohd. Aminudin QH301 Biology Alzheimer disease (AD) is a progressive neurodegenerative disorder associated with the disruption of neuronal function. Carotid Artery Reactivity (CAR) is a new biomarker method for AD detection which provides various advantages as compared to existing detection method. Current developed methods have either radiation risk (positron emission tomography [PET] and computed tomography [CT] scanning), high cost and long scanning duration (magnetic resonance imaging [MRI]) or lack accuracy (electroencephalography [EEG]). New AD detection method could be implemented using ultrasound machine by assessing the carotid artery condition since the impairment of this artery leads to brain hypoperfusion, a clinical feature of AD. CAR allows normal functioning artery to dilate in order to permit more bloods flow into the brain. The three different variables utilized to study the CAR were the carotid artery blood flow velocity, its diameter and cross sectional area. Healthy people and Alzheimer patient are believed to have different CAR value. Hence, this study emphasized on finding the normal reactivity value belonging to healthy people and Alzheimer patient. This CAR value could be used to differentiate between healthy people and Alzheimer patient as the new method of detection. The studied subject consisted of 40 healthy people and 20 Alzheimer patients. All subjects had been scanned with ultrasound machine using Doppler and 3D technique before and after performed exercise to achieve 85% of their Maximal Heart Rate (MHR). Readings of each reactivity variables before exercise (rest) and after exercise (stimulated) were recorded to be analyzed to compare its percentage increment value (reactivity). Based on the results, Alzheimer patient recorded very low reactivity value which were 21% (blood flow velocity), 8.1% (diameter changes) and 16.67% (area changes) while normal reactivity recorded high reactivity value which were 109%(blood flow velocity), 22.2% (diameter changes) and 49.59% (area changes). 2012-09 Thesis http://eprints.utm.my/id/eprint/78827/ http://eprints.utm.my/id/eprint/78827/1/MohdAminudinJamlosMFBME2012.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:110863 masters Universiti Teknologi Malaysia, Faculty of Biosciences and Medical Engineering Faculty of Biosciences and Medical Engineering
institution Universiti Teknologi Malaysia
collection UTM Institutional Repository
language English
topic QH301 Biology
spellingShingle QH301 Biology
Jamlos, Mohd. Aminudin
Alzheimer disease biomarker based on carotid artery reactivity
description Alzheimer disease (AD) is a progressive neurodegenerative disorder associated with the disruption of neuronal function. Carotid Artery Reactivity (CAR) is a new biomarker method for AD detection which provides various advantages as compared to existing detection method. Current developed methods have either radiation risk (positron emission tomography [PET] and computed tomography [CT] scanning), high cost and long scanning duration (magnetic resonance imaging [MRI]) or lack accuracy (electroencephalography [EEG]). New AD detection method could be implemented using ultrasound machine by assessing the carotid artery condition since the impairment of this artery leads to brain hypoperfusion, a clinical feature of AD. CAR allows normal functioning artery to dilate in order to permit more bloods flow into the brain. The three different variables utilized to study the CAR were the carotid artery blood flow velocity, its diameter and cross sectional area. Healthy people and Alzheimer patient are believed to have different CAR value. Hence, this study emphasized on finding the normal reactivity value belonging to healthy people and Alzheimer patient. This CAR value could be used to differentiate between healthy people and Alzheimer patient as the new method of detection. The studied subject consisted of 40 healthy people and 20 Alzheimer patients. All subjects had been scanned with ultrasound machine using Doppler and 3D technique before and after performed exercise to achieve 85% of their Maximal Heart Rate (MHR). Readings of each reactivity variables before exercise (rest) and after exercise (stimulated) were recorded to be analyzed to compare its percentage increment value (reactivity). Based on the results, Alzheimer patient recorded very low reactivity value which were 21% (blood flow velocity), 8.1% (diameter changes) and 16.67% (area changes) while normal reactivity recorded high reactivity value which were 109%(blood flow velocity), 22.2% (diameter changes) and 49.59% (area changes).
format Thesis
qualification_level Master's degree
author Jamlos, Mohd. Aminudin
author_facet Jamlos, Mohd. Aminudin
author_sort Jamlos, Mohd. Aminudin
title Alzheimer disease biomarker based on carotid artery reactivity
title_short Alzheimer disease biomarker based on carotid artery reactivity
title_full Alzheimer disease biomarker based on carotid artery reactivity
title_fullStr Alzheimer disease biomarker based on carotid artery reactivity
title_full_unstemmed Alzheimer disease biomarker based on carotid artery reactivity
title_sort alzheimer disease biomarker based on carotid artery reactivity
granting_institution Universiti Teknologi Malaysia, Faculty of Biosciences and Medical Engineering
granting_department Faculty of Biosciences and Medical Engineering
publishDate 2012
url http://eprints.utm.my/id/eprint/78827/1/MohdAminudinJamlosMFBME2012.pdf
_version_ 1747818081000882176

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