Investigation of using potentiostats and microfluidic devices for continuous ions detection

In the light of the importance of the bedside patient monitoring system, a miniaturized, flexible, versatile, disposable and cost effective bedside patient continuous monitoring system is essential. Therefore, this research addresses the development of a cost effective and miniaturize continuous mon...

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Main Author:	Noi, Sherrin
Format:	Thesis
Language:	English
Published:	2016
Subjects:	TP Chemical technology
Online Access:	http://eprints.utm.my/id/eprint/79032/1/SherrinNoiMFBME2016.pdf
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spelling	my-utm-ep.790322018-09-27T04:15:36Z Investigation of using potentiostats and microfluidic devices for continuous ions detection 2016-08 Noi, Sherrin TP Chemical technology In the light of the importance of the bedside patient monitoring system, a miniaturized, flexible, versatile, disposable and cost effective bedside patient continuous monitoring system is essential. Therefore, this research addresses the development of a cost effective and miniaturize continuous monitoring system. For electrochemical analysis, three potentiostats were used: EmStat, CheapStat and in house UTMStat. For lab-on-chip system, two models were proposed and their electrochemistry and pumping characteristics were studied. The 2 layers detection zone was developed through fused filament technology and replication moulding technique with a screen printed electrode attached together. It achieved the maximum flow rate of 0.30405 ml/min with resonance frequency of 20 Hz in micropump reverse direction. With the maximum frequency, the highest oxidation peak current of 15.86176 \|iA in cyclic voltammetry measurement was achieved by 10 mM ferrocyanide ions at potential 0.25 V. The monolithic microfluidic device was developed through sticker masks fabrication and replication moulding technique with two screen printed electrodes attached beneath the inlets and the outlets of the micropump. It achieved the maximum flow rate of 0.19693 ml/min with resonance frequency of 10 Hz in micropump forward direction. With the maximum frequency, the highest oxidation peak current of 28.32518 \|xA in cyclic voltammetry measurement was achieved by 10 mM ferrocyanide ions at potential 0.32 V. Additionally, the electrochemical investigation was extended by measuring the cyclic voltammetry measurements of chloride ions from a mixture by using EmStat and CheapStat. The highest oxidation peak was observed at 61.26875 \|jA and 1.04400 \|±A by using EmStat and CheapStat respectively at potential 0.13 V. Specifically, the monolithic microfluidic device is well integrated in lab-on-chip system with the advantage of miniaturize with the dimensions of 41 mm x 26 mm, cost effective by using sticker masks fabrication and replication moulding technique, disposability since it is inexpensive and meant for biomedical analysis, flexibility where it can be used for other ions detection just by changing the screen printed electrode and can measure the data during pumping. This research successfully provides an alternative approach for continuous monitoring of ferrocyanide and chloride ions detection via cyclic voltammetry and amperometry measurements. 2016-08 Thesis http://eprints.utm.my/id/eprint/79032/ http://eprints.utm.my/id/eprint/79032/1/SherrinNoiMFBME2016.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:110540 masters Universiti Teknologi Malaysia, Faculty of Biosciences and Medical Engineering Faculty of Biosciences and Medical Engineering
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	TP Chemical technology
spellingShingle	TP Chemical technology Noi, Sherrin Investigation of using potentiostats and microfluidic devices for continuous ions detection
description	In the light of the importance of the bedside patient monitoring system, a miniaturized, flexible, versatile, disposable and cost effective bedside patient continuous monitoring system is essential. Therefore, this research addresses the development of a cost effective and miniaturize continuous monitoring system. For electrochemical analysis, three potentiostats were used: EmStat, CheapStat and in house UTMStat. For lab-on-chip system, two models were proposed and their electrochemistry and pumping characteristics were studied. The 2 layers detection zone was developed through fused filament technology and replication moulding technique with a screen printed electrode attached together. It achieved the maximum flow rate of 0.30405 ml/min with resonance frequency of 20 Hz in micropump reverse direction. With the maximum frequency, the highest oxidation peak current of 15.86176 \|iA in cyclic voltammetry measurement was achieved by 10 mM ferrocyanide ions at potential 0.25 V. The monolithic microfluidic device was developed through sticker masks fabrication and replication moulding technique with two screen printed electrodes attached beneath the inlets and the outlets of the micropump. It achieved the maximum flow rate of 0.19693 ml/min with resonance frequency of 10 Hz in micropump forward direction. With the maximum frequency, the highest oxidation peak current of 28.32518 \|xA in cyclic voltammetry measurement was achieved by 10 mM ferrocyanide ions at potential 0.32 V. Additionally, the electrochemical investigation was extended by measuring the cyclic voltammetry measurements of chloride ions from a mixture by using EmStat and CheapStat. The highest oxidation peak was observed at 61.26875 \|jA and 1.04400 \|±A by using EmStat and CheapStat respectively at potential 0.13 V. Specifically, the monolithic microfluidic device is well integrated in lab-on-chip system with the advantage of miniaturize with the dimensions of 41 mm x 26 mm, cost effective by using sticker masks fabrication and replication moulding technique, disposability since it is inexpensive and meant for biomedical analysis, flexibility where it can be used for other ions detection just by changing the screen printed electrode and can measure the data during pumping. This research successfully provides an alternative approach for continuous monitoring of ferrocyanide and chloride ions detection via cyclic voltammetry and amperometry measurements.
format	Thesis
qualification_level	Master's degree
author	Noi, Sherrin
author_facet	Noi, Sherrin
author_sort	Noi, Sherrin
title	Investigation of using potentiostats and microfluidic devices for continuous ions detection
title_short	Investigation of using potentiostats and microfluidic devices for continuous ions detection
title_full	Investigation of using potentiostats and microfluidic devices for continuous ions detection
title_fullStr	Investigation of using potentiostats and microfluidic devices for continuous ions detection
title_full_unstemmed	Investigation of using potentiostats and microfluidic devices for continuous ions detection
title_sort	investigation of using potentiostats and microfluidic devices for continuous ions detection
granting_institution	Universiti Teknologi Malaysia, Faculty of Biosciences and Medical Engineering
granting_department	Faculty of Biosciences and Medical Engineering
publishDate	2016
url	http://eprints.utm.my/id/eprint/79032/1/SherrinNoiMFBME2016.pdf
_version_	1747818130388811776

Investigation of using potentiostats and microfluidic devices for continuous ions detection

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