Synthesis and characterization of biodegradable and thermoresponsive poly(1,8-Octanediol-glycerol-1,12-Dodecanedioate) and its composites for tissue engineering applications

Synthesis and characterization of biodegradable and thermoresponsive poly(1,8-Octanediol-glycerol-1,12-Dodecanedioate) and its composites for tissue engineering applications

Biodegradable polyesters, poly(1,8-octanediol–glycerol–1,12-dodecanedioate)s (POGDA)s, were synthesized via polycondensation polymerization method without solvent and catalyst and with different monomer molar ratios. Formation of POGDA was confirmed with structural analysis by Fourier transform infr...

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Main Author: Lee, Xiau Yeen
Format: Thesis
Language:English
Published: 2017
Subjects:
TP Chemical technology
Online Access:http://eprints.utm.my/id/eprint/79345/1/LeeXiauYeenPFChE2017.pdf
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spelling my-utm-ep.793452018-10-14T08:44:41Z Synthesis and characterization of biodegradable and thermoresponsive poly(1,8-Octanediol-glycerol-1,12-Dodecanedioate) and its composites for tissue engineering applications 2017 Lee, Xiau Yeen TP Chemical technology Biodegradable polyesters, poly(1,8-octanediol–glycerol–1,12-dodecanedioate)s (POGDA)s, were synthesized via polycondensation polymerization method without solvent and catalyst and with different monomer molar ratios. Formation of POGDA was confirmed with structural analysis by Fourier transform infrared spectroscopy. The effects of varying the monomer molar ratio on POGDA properties were illustrated in the gel content and swelling analysis, ultraviolet–visible spectroscopy, thermal gravimetric analysis, differential scanning calorimetry, x-ray diffraction, tensile test and in vitro degradation tests. In vitro degradation tests were performed in phosphate-buffered solution at 37 °C for 60 days. Thermoresponsive behavior was revealed by POGDA with 0.5 mole ratio of glycerol (Gly), and bending tests were performed to study the shape memory effect. In vitro cytotoxicity tests and cell proliferation tests suggested that these POGDA polymers have potential applications in biomedical fields such as tissue engineering. POGDA (0.5 Gly) loading with hydroxyapatite (HA) were prepared using similar polycondensation polymerization method. Addition of HA improved the mechanical properties and decreased the degradation rate of the composites. Scaffolds were fabricated from POGDA/HA composites using solvent-free salt leaching method. Pore structure in scaffold was visualized with field emission scanning electron microscope and porosities were measured using liquid displacement test. The porous scaffolds fabricated from POGDA/HA composites were found to exhibit thermoresponsive behavior. The cell proliferation tests suggested that the scaffolds have good biocompatibility with fibroblast cells and have potential to be used in tissue engineering. 2017 Thesis http://eprints.utm.my/id/eprint/79345/ http://eprints.utm.my/id/eprint/79345/1/LeeXiauYeenPFChE2017.pdf application/pdf en public phd doctoral Universiti Teknologi Malaysia, Faculty of Chemical & Energy Engineering Faculty of Chemical & Energy Engineering
institution Universiti Teknologi Malaysia
collection UTM Institutional Repository
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
Lee, Xiau Yeen
Synthesis and characterization of biodegradable and thermoresponsive poly(1,8-Octanediol-glycerol-1,12-Dodecanedioate) and its composites for tissue engineering applications
description Biodegradable polyesters, poly(1,8-octanediol–glycerol–1,12-dodecanedioate)s (POGDA)s, were synthesized via polycondensation polymerization method without solvent and catalyst and with different monomer molar ratios. Formation of POGDA was confirmed with structural analysis by Fourier transform infrared spectroscopy. The effects of varying the monomer molar ratio on POGDA properties were illustrated in the gel content and swelling analysis, ultraviolet–visible spectroscopy, thermal gravimetric analysis, differential scanning calorimetry, x-ray diffraction, tensile test and in vitro degradation tests. In vitro degradation tests were performed in phosphate-buffered solution at 37 °C for 60 days. Thermoresponsive behavior was revealed by POGDA with 0.5 mole ratio of glycerol (Gly), and bending tests were performed to study the shape memory effect. In vitro cytotoxicity tests and cell proliferation tests suggested that these POGDA polymers have potential applications in biomedical fields such as tissue engineering. POGDA (0.5 Gly) loading with hydroxyapatite (HA) were prepared using similar polycondensation polymerization method. Addition of HA improved the mechanical properties and decreased the degradation rate of the composites. Scaffolds were fabricated from POGDA/HA composites using solvent-free salt leaching method. Pore structure in scaffold was visualized with field emission scanning electron microscope and porosities were measured using liquid displacement test. The porous scaffolds fabricated from POGDA/HA composites were found to exhibit thermoresponsive behavior. The cell proliferation tests suggested that the scaffolds have good biocompatibility with fibroblast cells and have potential to be used in tissue engineering.
format Thesis
qualification_name Doctor of Philosophy (PhD.)
qualification_level Doctorate
author Lee, Xiau Yeen
author_facet Lee, Xiau Yeen
author_sort Lee, Xiau Yeen
title Synthesis and characterization of biodegradable and thermoresponsive poly(1,8-Octanediol-glycerol-1,12-Dodecanedioate) and its composites for tissue engineering applications
title_short Synthesis and characterization of biodegradable and thermoresponsive poly(1,8-Octanediol-glycerol-1,12-Dodecanedioate) and its composites for tissue engineering applications
title_full Synthesis and characterization of biodegradable and thermoresponsive poly(1,8-Octanediol-glycerol-1,12-Dodecanedioate) and its composites for tissue engineering applications
title_fullStr Synthesis and characterization of biodegradable and thermoresponsive poly(1,8-Octanediol-glycerol-1,12-Dodecanedioate) and its composites for tissue engineering applications
title_full_unstemmed Synthesis and characterization of biodegradable and thermoresponsive poly(1,8-Octanediol-glycerol-1,12-Dodecanedioate) and its composites for tissue engineering applications
title_sort synthesis and characterization of biodegradable and thermoresponsive poly(1,8-octanediol-glycerol-1,12-dodecanedioate) and its composites for tissue engineering applications
granting_institution Universiti Teknologi Malaysia, Faculty of Chemical & Energy Engineering
granting_department Faculty of Chemical & Energy Engineering
publishDate 2017
url http://eprints.utm.my/id/eprint/79345/1/LeeXiauYeenPFChE2017.pdf
_version_ 1747818205812883456

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