Low power cmos potentiometric circuit design for label-free DNA detection

DNA detector is one of the main way to use in order to detect diseases, preventing crime and so on. The DNA detecting process is limited due to the bulky and expensive existing DNA detector machine. As the demand of the small, portable and inexpensive biosensor for point-of-care testing aid and medi...

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Main Author:	Khalid, Muhammad Harris
Format:	Thesis
Language:	English
Published:	2019
Subjects:	TK Electrical engineering Electronics Nuclear engineering
Online Access:	http://eprints.utm.my/id/eprint/86050/1/MuhammadHarrisKhalidMSKE2019.pdf
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id	my-utm-ep.86050
record_format	uketd_dc
spelling	my-utm-ep.860502020-08-30T08:53:06Z Low power cmos potentiometric circuit design for label-free DNA detection 2019 Khalid, Muhammad Harris TK Electrical engineering. Electronics Nuclear engineering DNA detector is one of the main way to use in order to detect diseases, preventing crime and so on. The DNA detecting process is limited due to the bulky and expensive existing DNA detector machine. As the demand of the small, portable and inexpensive biosensor for point-of-care testing aid and medical diagnostic, the research and development of biosensor are increasing exponentially every year. The aim of this work is to develop an on-chip Complementary Metal Oxide Semiconductor (CMOS) biosensor circuit based on the charge-modulated field effect transistor (CMFET) for a label-free deoxyribonucleic acid (DNA) detection. This project focusing on low voltage and low power design potentiometric DNA detection circuit. Overall of detection circuit consists of two main circuits which are self-cascode source drain follower and two-stage differential amplifier. The proposed detection circuit is designed and simulates using 0.13 µm Silterra CMOS fabrication with 1.2 V supply. The power consumption of the improved source-drain follower circuit is 1.36 µW and with gain of 0.998 dB. The two-stage differential amplifier achives a voltage gain of 56.02 dB and high common mode rejection ration (CMRR) of 90 dB. 2019 Thesis http://eprints.utm.my/id/eprint/86050/ http://eprints.utm.my/id/eprint/86050/1/MuhammadHarrisKhalidMSKE2019.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:132685 masters Universiti Teknologi Malaysia, Faculty of Engineering - School of Electrical Engineering Faculty of Engineering - School of Electrical Engineering
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	TK Electrical engineering Electronics Nuclear engineering
spellingShingle	TK Electrical engineering Electronics Nuclear engineering Khalid, Muhammad Harris Low power cmos potentiometric circuit design for label-free DNA detection
description	DNA detector is one of the main way to use in order to detect diseases, preventing crime and so on. The DNA detecting process is limited due to the bulky and expensive existing DNA detector machine. As the demand of the small, portable and inexpensive biosensor for point-of-care testing aid and medical diagnostic, the research and development of biosensor are increasing exponentially every year. The aim of this work is to develop an on-chip Complementary Metal Oxide Semiconductor (CMOS) biosensor circuit based on the charge-modulated field effect transistor (CMFET) for a label-free deoxyribonucleic acid (DNA) detection. This project focusing on low voltage and low power design potentiometric DNA detection circuit. Overall of detection circuit consists of two main circuits which are self-cascode source drain follower and two-stage differential amplifier. The proposed detection circuit is designed and simulates using 0.13 µm Silterra CMOS fabrication with 1.2 V supply. The power consumption of the improved source-drain follower circuit is 1.36 µW and with gain of 0.998 dB. The two-stage differential amplifier achives a voltage gain of 56.02 dB and high common mode rejection ration (CMRR) of 90 dB.
format	Thesis
qualification_level	Master's degree
author	Khalid, Muhammad Harris
author_facet	Khalid, Muhammad Harris
author_sort	Khalid, Muhammad Harris
title	Low power cmos potentiometric circuit design for label-free DNA detection
title_short	Low power cmos potentiometric circuit design for label-free DNA detection
title_full	Low power cmos potentiometric circuit design for label-free DNA detection
title_fullStr	Low power cmos potentiometric circuit design for label-free DNA detection
title_full_unstemmed	Low power cmos potentiometric circuit design for label-free DNA detection
title_sort	low power cmos potentiometric circuit design for label-free dna detection
granting_institution	Universiti Teknologi Malaysia, Faculty of Engineering - School of Electrical Engineering
granting_department	Faculty of Engineering - School of Electrical Engineering
publishDate	2019
url	http://eprints.utm.my/id/eprint/86050/1/MuhammadHarrisKhalidMSKE2019.pdf
_version_	1747818486181134336

Low power cmos potentiometric circuit design for label-free DNA detection

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