Laboratory Animal Allergy (LAA) among the animal facilities’ workers in a research institute: A clinical survey

Research animal facilities had been identified as a risky environment for the development of Laboratory Animal Allergy (LAA) among the exposed workers. The risk degree is in parallel with the nature of contact, intensity of exposure and individual susceptibility. Early recognition of LAA via active...

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Main Author:	Heng, Pei Pei
Format:	Thesis
Language:	eng eng eng
Published:	2019
Subjects:	HF5001-6182 Business
Online Access:	https://etd.uum.edu.my/8395/1/s824118_01.pdf https://etd.uum.edu.my/8395/2/s824118_02.pdf https://etd.uum.edu.my/8395/3/824118%20REFERENCES.docx
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id	my-uum-etd.8395
record_format	uketd_dc
spelling	my-uum-etd.83952022-08-08T04:48:57Z Laboratory Animal Allergy (LAA) among the animal facilities’ workers in a research institute: A clinical survey 2019 Heng, Pei Pei Othman Yeop Abdullah Graduate School of Business Othman Yeop Abdullah Graduate School of Business HF5001-6182 Business Research animal facilities had been identified as a risky environment for the development of Laboratory Animal Allergy (LAA) among the exposed workers. The risk degree is in parallel with the nature of contact, intensity of exposure and individual susceptibility. Early recognition of LAA via active clinical surveillance is imperative before it progresses into occupational asthma with chronic disability. This study aimed to determine the prevalence of LAA among animal facilities’ workers in Institute for Medical Research, Malaysia together with its associated exposure or environmental risk factors. This cross-sectional study recruited a total of 87 workers exposed to animal allergen and 87 control subjects. Self-administered LAA questionnaire contained details of occupational and socio-environmental history as well as lung function test (spirometry) were employed as study tools. Statistical analysis were performed using SPSS version 20, utilizing descriptive analysis , cross tabulation, independent t-test ,Mann Whitney U-test and Multivariable Logistic Regression (MLR).More than half of the exposed subjects were reported at least one LAA symptoms (58.6%) and declined ling function (56.3%). Upper respiratory symptoms were the most prevalent LAA symptoms (49.4%). There was significant association between the reported symptoms and abnormal lung profile (p<0.05). In term of lung function values, the mean FEV1, median FVC and mean FEV1/FVC were significantly lower among the exposed group compared to the control group (p<0.001). MLR substantiated that atopic workers, smokers and those did not comply to full PPE regularly upon animal contact were more likely to develop LAA. LAA is an acknowledged occupational hazard. Therefore knowing the existing prevalence and its risk factors to design an effective LAA prevention program consisted of exposure avoidance as well as exposure reduction which combines the engineering control, administrative control and PPE is of paramount importance. 2019 Thesis https://etd.uum.edu.my/8395/ https://etd.uum.edu.my/8395/1/s824118_01.pdf text eng public https://etd.uum.edu.my/8395/2/s824118_02.pdf text eng public https://etd.uum.edu.my/8395/3/824118%20REFERENCES.docx text eng public other masters Universiti Utara Malaysia
institution	Universiti Utara Malaysia
collection	UUM ETD
language	eng eng eng
topic	HF5001-6182 Business
spellingShingle	HF5001-6182 Business Heng, Pei Pei Laboratory Animal Allergy (LAA) among the animal facilities’ workers in a research institute: A clinical survey
description	Research animal facilities had been identified as a risky environment for the development of Laboratory Animal Allergy (LAA) among the exposed workers. The risk degree is in parallel with the nature of contact, intensity of exposure and individual susceptibility. Early recognition of LAA via active clinical surveillance is imperative before it progresses into occupational asthma with chronic disability. This study aimed to determine the prevalence of LAA among animal facilities’ workers in Institute for Medical Research, Malaysia together with its associated exposure or environmental risk factors. This cross-sectional study recruited a total of 87 workers exposed to animal allergen and 87 control subjects. Self-administered LAA questionnaire contained details of occupational and socio-environmental history as well as lung function test (spirometry) were employed as study tools. Statistical analysis were performed using SPSS version 20, utilizing descriptive analysis , cross tabulation, independent t-test ,Mann Whitney U-test and Multivariable Logistic Regression (MLR).More than half of the exposed subjects were reported at least one LAA symptoms (58.6%) and declined ling function (56.3%). Upper respiratory symptoms were the most prevalent LAA symptoms (49.4%). There was significant association between the reported symptoms and abnormal lung profile (p<0.05). In term of lung function values, the mean FEV1, median FVC and mean FEV1/FVC were significantly lower among the exposed group compared to the control group (p<0.001). MLR substantiated that atopic workers, smokers and those did not comply to full PPE regularly upon animal contact were more likely to develop LAA. LAA is an acknowledged occupational hazard. Therefore knowing the existing prevalence and its risk factors to design an effective LAA prevention program consisted of exposure avoidance as well as exposure reduction which combines the engineering control, administrative control and PPE is of paramount importance.
format	Thesis
qualification_name	other
qualification_level	Master's degree
author	Heng, Pei Pei
author_facet	Heng, Pei Pei
author_sort	Heng, Pei Pei
title	Laboratory Animal Allergy (LAA) among the animal facilities’ workers in a research institute: A clinical survey
title_short	Laboratory Animal Allergy (LAA) among the animal facilities’ workers in a research institute: A clinical survey
title_full	Laboratory Animal Allergy (LAA) among the animal facilities’ workers in a research institute: A clinical survey
title_fullStr	Laboratory Animal Allergy (LAA) among the animal facilities’ workers in a research institute: A clinical survey
title_full_unstemmed	Laboratory Animal Allergy (LAA) among the animal facilities’ workers in a research institute: A clinical survey
title_sort	laboratory animal allergy (laa) among the animal facilities’ workers in a research institute: a clinical survey
granting_institution	Universiti Utara Malaysia
granting_department	Othman Yeop Abdullah Graduate School of Business
publishDate	2019
url	https://etd.uum.edu.my/8395/1/s824118_01.pdf https://etd.uum.edu.my/8395/2/s824118_02.pdf https://etd.uum.edu.my/8395/3/824118%20REFERENCES.docx
_version_	1747828384867549184

Laboratory Animal Allergy (LAA) among the animal facilities’ workers in a research institute: A clinical survey

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