Chemical constituents from Ficus deltoidea var. kunstleri corner and its antidiabetic property (IR)

<p>The aims of this study are to determine the chemical structures of the isolated compounds from the leaves and stem bark of Ficus deltoidea var. kunstleri by using various type of spectroscopy and to evaluate their antidiabetic activities. The isolation process of isolated compounds...

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Main Author: Nor Afifah Md Jamal
Format: thesis
Language:eng
Published: 2017
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Online Access:https://ir.upsi.edu.my/detailsg.php?det=3349
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spelling oai:ir.upsi.edu.my:33492020-02-27 Chemical constituents from Ficus deltoidea var. kunstleri corner and its antidiabetic property (IR) 2017 Nor Afifah Md Jamal QK Botany <p>The aims of this study are to determine the chemical structures of the isolated compounds from the leaves and stem bark of Ficus deltoidea var. kunstleri by using various type of spectroscopy and to evaluate their antidiabetic activities. The isolation process of isolated compounds involved extraction, separation and purification by using column chromatography and preparative thin layer chromatography techniques. These compounds were structurally identified by using various spectroscopic techniques such as 1D (1H,13C and DEPT) and 2D-NMR (HMBC,HMQC and COSY), UV, IR and mass spectrometry; and also by comparison with previous studies. Study on in-vitro antidiabetic activities were evaluated by using -glucosidase inhibitory assay with 4- nitrophenyl--D-glucopyranoside (pNPG) as substrate. As findings, chromatographic purification of F. deltoidea var. kunstleri afforded eleven chemical compounds: - tocopherol, -amyrin cinnamate, triglycerides fatty acids, hexadecyl palmitate, bergapten which are first time reported from this species and two mixture of compounds; mixture of pentacyclic triterpenes; lupeol, -amyrin, -amyrin and a mixture of sterols; stigmasterol and -sitosterol together with a new ester triterpene; euphol ester. The bioactivity of glucosidase inhibition on the crude extracts and isolated compounds from this variation was first time reported. As conclusion, all crude extracts and the isolated compounds were inactive against the in-vitro -glucosidase activity and have no potential as antidiabetic drugs. The implication is the results from this study can be used as future references to discover possible potential new drugs.</p> 2017 thesis https://ir.upsi.edu.my/detailsg.php?det=3349 https://ir.upsi.edu.my/detailsg.php?det=3349 text eng closedAccess Masters Universiti Pendidikan Sultan Idris Fakulti Sains dan Matematik N/A
institution Universiti Pendidikan Sultan Idris
collection UPSI Digital Repository
language eng
topic QK Botany
spellingShingle QK Botany
Nor Afifah Md Jamal
Chemical constituents from Ficus deltoidea var. kunstleri corner and its antidiabetic property (IR)
description <p>The aims of this study are to determine the chemical structures of the isolated compounds from the leaves and stem bark of Ficus deltoidea var. kunstleri by using various type of spectroscopy and to evaluate their antidiabetic activities. The isolation process of isolated compounds involved extraction, separation and purification by using column chromatography and preparative thin layer chromatography techniques. These compounds were structurally identified by using various spectroscopic techniques such as 1D (1H,13C and DEPT) and 2D-NMR (HMBC,HMQC and COSY), UV, IR and mass spectrometry; and also by comparison with previous studies. Study on in-vitro antidiabetic activities were evaluated by using -glucosidase inhibitory assay with 4- nitrophenyl--D-glucopyranoside (pNPG) as substrate. As findings, chromatographic purification of F. deltoidea var. kunstleri afforded eleven chemical compounds: - tocopherol, -amyrin cinnamate, triglycerides fatty acids, hexadecyl palmitate, bergapten which are first time reported from this species and two mixture of compounds; mixture of pentacyclic triterpenes; lupeol, -amyrin, -amyrin and a mixture of sterols; stigmasterol and -sitosterol together with a new ester triterpene; euphol ester. The bioactivity of glucosidase inhibition on the crude extracts and isolated compounds from this variation was first time reported. As conclusion, all crude extracts and the isolated compounds were inactive against the in-vitro -glucosidase activity and have no potential as antidiabetic drugs. The implication is the results from this study can be used as future references to discover possible potential new drugs.</p>
format thesis
qualification_name
qualification_level Master's degree
author Nor Afifah Md Jamal
author_facet Nor Afifah Md Jamal
author_sort Nor Afifah Md Jamal
title Chemical constituents from Ficus deltoidea var. kunstleri corner and its antidiabetic property (IR)
title_short Chemical constituents from Ficus deltoidea var. kunstleri corner and its antidiabetic property (IR)
title_full Chemical constituents from Ficus deltoidea var. kunstleri corner and its antidiabetic property (IR)
title_fullStr Chemical constituents from Ficus deltoidea var. kunstleri corner and its antidiabetic property (IR)
title_full_unstemmed Chemical constituents from Ficus deltoidea var. kunstleri corner and its antidiabetic property (IR)
title_sort chemical constituents from ficus deltoidea var. kunstleri corner and its antidiabetic property (ir)
granting_institution Universiti Pendidikan Sultan Idris
granting_department Fakulti Sains dan Matematik
publishDate 2017
url https://ir.upsi.edu.my/detailsg.php?det=3349
_version_ 1747833073157799936