Anti-diabetic effect of agarwood leaf extracts on straptozotocin-induced type II diabetic ICR mice

Alternative treatments of insulin-independent diabetes mellitus have attracted many researchersover the years. The treatment should have a clearer mechanism of action and easier to administer.Asian traditional medicine contains a number of herbal extracts believed to combat thesymptoms of diabetes m...

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Main Author:	Fayyadh, Aws Ali
Format:	thesis
Language:	eng
Published:	2019
Subjects:	RA Public aspects of medicine
Online Access:	https://ir.upsi.edu.my/detailsg.php?det=6552
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institution	Universiti Pendidikan Sultan Idris
collection	UPSI Digital Repository
language	eng
topic	RA Public aspects of medicine
spellingShingle	RA Public aspects of medicine Fayyadh, Aws Ali Anti-diabetic effect of agarwood leaf extracts on straptozotocin-induced type II diabetic ICR mice
description	Alternative treatments of insulin-independent diabetes mellitus have attracted many researchersover the years. The treatment should have a clearer mechanism of action and easier to administer.Asian traditional medicine contains a number of herbal extracts believed to combat thesymptoms of diabetes mellitus. Thus, the purpose of this study was to investigate the potentialof agarwood leaf extracts against type II diabetic ICR mice. A group of ICR mice of both sexes,aged 8 weeks were induced by a single intraperitoneal injection of 100 mg/kg body weight ofstreptozotocin (STZ). Mice (fasting) with blood glucose over 200 mg/dl were used in thisexperiment. Diabetic mice were divided into three groups and were forced fed with 50, 100 and150 mg plant extract /kg body weight for 14 consecutive days respectivly. Two different typesof solvents used in this study were distilled water and 95% methanol. Aqueous and methanolicextracts of Aquilaria malaccensis leaf exhibited a significant reduction of hyperglycemia infasting diabetic mice at the lowest concentration (50 mg/kg b.w). Both extracts with differentsolvents reduced hyperglycemia within three days of administration and these were observed forall doses. For methanolic extract, low (50 mg/kg body weight) and moderate (100 mg/kg bodyweight) doses, reduced hyperglycemia in fasting diabetic mice compered with the highest dose(150 mg/kg body weight) after two hours of forced fed. In conclusion, these data suggest thatboth extracts of agarwood leaf possess potential anti-diabetic activity in both diabetic male andfemale mice. Hence, active constituents of agarwood leaf extracts which responsible for antidiabeticactivity requires further to be investigated and these findings contribute to potentialdiabetic treatment.
format	thesis
qualification_name
qualification_level	Master's degree
author	Fayyadh, Aws Ali
author_facet	Fayyadh, Aws Ali
author_sort	Fayyadh, Aws Ali
title	Anti-diabetic effect of agarwood leaf extracts on straptozotocin-induced type II diabetic ICR mice
title_short	Anti-diabetic effect of agarwood leaf extracts on straptozotocin-induced type II diabetic ICR mice
title_full	Anti-diabetic effect of agarwood leaf extracts on straptozotocin-induced type II diabetic ICR mice
title_fullStr	Anti-diabetic effect of agarwood leaf extracts on straptozotocin-induced type II diabetic ICR mice
title_full_unstemmed	Anti-diabetic effect of agarwood leaf extracts on straptozotocin-induced type II diabetic ICR mice
title_sort	anti-diabetic effect of agarwood leaf extracts on straptozotocin-induced type ii diabetic icr mice
granting_institution	Universiti Pendidikan Sultan Idris
granting_department	Fakulti Sains dan Matematik
publishDate	2019
url	https://ir.upsi.edu.my/detailsg.php?det=6552
_version_	1747833277568253952
spelling	oai:ir.upsi.edu.my:65522022-01-06 Anti-diabetic effect of agarwood leaf extracts on straptozotocin-induced type II diabetic ICR mice 2019 Fayyadh, Aws Ali RA Public aspects of medicine Alternative treatments of insulin-independent diabetes mellitus have attracted many researchersover the years. The treatment should have a clearer mechanism of action and easier to administer.Asian traditional medicine contains a number of herbal extracts believed to combat thesymptoms of diabetes mellitus. Thus, the purpose of this study was to investigate the potentialof agarwood leaf extracts against type II diabetic ICR mice. A group of ICR mice of both sexes,aged 8 weeks were induced by a single intraperitoneal injection of 100 mg/kg body weight ofstreptozotocin (STZ). Mice (fasting) with blood glucose over 200 mg/dl were used in thisexperiment. Diabetic mice were divided into three groups and were forced fed with 50, 100 and150 mg plant extract /kg body weight for 14 consecutive days respectivly. Two different typesof solvents used in this study were distilled water and 95% methanol. Aqueous and methanolicextracts of Aquilaria malaccensis leaf exhibited a significant reduction of hyperglycemia infasting diabetic mice at the lowest concentration (50 mg/kg b.w). Both extracts with differentsolvents reduced hyperglycemia within three days of administration and these were observed forall doses. For methanolic extract, low (50 mg/kg body weight) and moderate (100 mg/kg bodyweight) doses, reduced hyperglycemia in fasting diabetic mice compered with the highest dose(150 mg/kg body weight) after two hours of forced fed. In conclusion, these data suggest thatboth extracts of agarwood leaf possess potential anti-diabetic activity in both diabetic male andfemale mice. Hence, active constituents of agarwood leaf extracts which responsible for antidiabeticactivity requires further to be investigated and these findings contribute to potentialdiabetic treatment. 2019 thesis https://ir.upsi.edu.my/detailsg.php?det=6552 https://ir.upsi.edu.my/detailsg.php?det=6552 text eng closedAccess Masters Universiti Pendidikan Sultan Idris Fakulti Sains dan Matematik Abdirahman, Y., Juma, K., Makori, W., Agyirifo, D., & Ngugi, M. (2015). Blood GlucoseLowering Effect and Safety of the Aqueous Leaf Extracts of Zanha africana.Pharmaceutica Analytica Acta, 6(9).Abo, K., Fred-Jaiyesimi, A., & Jaiyesimi, A. (2008). Ethnobotanical studies of medicinal plantsused in the management of diabetes mellitus in South Western Nigeria. Journal ofEthnopharmacology, 115(1), 67-71.Adam, A. Z., Lee, S. Y., & Mohamed, R. (2017). Pharmacological properties of agarwood tea derivedfrom Aquilaria (Thymelaeaceae) leaves: An emerging contemporary herbal drink. Journal of HerbalMedicine.AIHW. 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