Preparation, characterisation and effectiveness of nanocomposites based on Go-Fe3O4 as nanocarriers for insecticide compounds
<p>This research aimed to prepare, characterise and study the effectiveness of two</p><p>magnetic graphene oxide-based nanocomposites, namely gellan gum-graphene</p><p>oxide (GG-GO-Fe3O4) and pectin-graphene oxide (PEC-GO-Fe3O4) a...
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| Format: | thesis |
| Language: | eng |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://ir.upsi.edu.my/detailsg.php?det=8818 |
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| Summary: | <p>This research aimed to prepare, characterise and study the effectiveness of two</p><p>magnetic graphene oxide-based nanocomposites, namely gellan gum-graphene</p><p>oxide (GG-GO-Fe3O4) and pectin-graphene oxide (PEC-GO-Fe3O4) as</p><p>nanocarriers for permethrin and cinnamaldehyde insecticide compounds. This</p><p>research is divided into three parts, namely preparation, characterisation and</p><p>effectiveness studies. Nanocomposites with amorphous structure were</p><p>successfully produced based on the existence of conjugation mechanism between</p><p>GG and PEC with iron oxide at wavenumber peak 650 cm-1. Results from</p><p>thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC)</p><p>have shown that the nanocomposites loaded with insecticides are thermally stable.</p><p>Performance study of nanocomposites loaded with insecticides towards Aedes</p><p>aegypti larvae was analysed through Abbotts and Probits formula via in vitro at</p><p>different pH using ultraviolet-visible (UV-Vis) spectrometer. The encapsulation</p><p>of insecticide to nanocarriers was successfully carried out based on the change in</p><p>intensity and wavenumber of absorption bands from Fourier Transform Infrared</p><p>Spectrometer (FTIR) analysis and size increment of nanocarriers in the range of</p><p>18.2 to 70.1%. The formulated nanocarriers have successfully prolonged the</p><p>release duration of permethrin and cinnamaldehyde by 15 and 24 hours,</p><p>respectively. The release profiles of insecticide compounds were best fitted by</p><p>Korsemeyer-Peppas kinetic model. Formulation of GG-GO-Fe3O4 nanocarrier</p><p>loaded with cinnamaldehyde was found as the most effective formulation to</p><p>control A. aegypti larvae. In conclusion, both nanocarriers studied have shown</p><p>outstanding performance in loading and releasing permethrin and cinnamaldehyde</p><p>in larvicide formulations. In implication, the application of both environmental</p><p>friendly nanocarriers in larvicide formulations could reduce mosquito borne</p><p>diseases and sustain the environment.</p> |
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