Identification of the cellular origin and "stemness" phenotype of malignant rhabdoid tumours (MRT) may represent a new therapeutic approach in paediatric oncology
introduction: Malignant Rhabdoid Tumours (MRT) arc especially lethal cancers that predominantly occur in infants and young ehildrcn. MRT arc caused by biallelic inactivation of a single gene; SMARCB I which is a component of SWI/S F chromatin remodelling complex. The tumours can be found almost ever...
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| Format: | Thesis Book |
| Language: | English |
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Table of Contents:
- 1. Introduction
- 2. Materials and Methods
- 3. An analysis of putative cell of origin for malignant rhabdoid tumours (MRT)
- 4. Somatic CRISPS/CAS9 mediated knockout of SMARCB1 in a putative cell of origin: a system for the development of Malignant Rhabdoid Tumours (MRT) models and identification of potential therapeutic targets
- 5. Establishing Tumoursphere assay of Malignant Rhabdoid Tumours (MRT) cell lines for self-renewal identification and analysis
- 6. Therapeutic targeting of the self-renewal machinery as a novel Malignant Rhabdoid Tumour cancer therapy strategy
- 7. Conclusion
- 8. Reference