Ultrasonic- and microwave-assisted extraction of curcuminoids and cyclodextrin complexes of curcumin from C. domestica Val.

This study investigates the isolation of curcuminoids from Curcuma domestica Val. using ultrasonic-assisted extraction (UAE), microwave-assisted extraction (MAE) compared with conventional cold solvent extraction method and the use of inclusion complexation of curcumin with methyl-?-cyclodextrin (Mß...

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Main Author:	Jume, Binta Hadi
Format:	Thesis
Language:	English
Published:	2014
Subjects:	QD Chemistry
Online Access:	http://eprints.utm.my/id/eprint/77890/1/BintaHadiJumePFS2014.pdf
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spelling	my-utm-ep.778902018-07-23T05:46:07Z Ultrasonic- and microwave-assisted extraction of curcuminoids and cyclodextrin complexes of curcumin from C. domestica Val. 2014-05 Jume, Binta Hadi QD Chemistry This study investigates the isolation of curcuminoids from Curcuma domestica Val. using ultrasonic-assisted extraction (UAE), microwave-assisted extraction (MAE) compared with conventional cold solvent extraction method and the use of inclusion complexation of curcumin with methyl-?-cyclodextrin (Mß-CD) for improving their solubility. The extractions were optimized by determining the content of three curcuminoid markers, namely curcumin (C), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC). The extraction efficiencies were compared in terms of extraction time, sample through-put and solvent consumption. The optimized parameters for UAE of curcuminoids were extraction amplitude of 100, particle size of 0.30-0.60 mm, extraction time of 20 min, extraction solvent volume of 10 mL and extraction temperature of 60°C. Meanwhile, the relative recoveries (RRs) for aqueous extraction were in the range of 91.59-98.99%, 89.79- 94.95% and 89.33-94.77% for C, DMC and BDMC, respectively. Although UAE using methanol resulted in a slightly higher extraction yield and shorter extraction time compared to those using water, both methods showed similar pattern of results. Despite these, water is cost effective, safe and environmentally friendly. These advantages of aqueous solvent can be used as a yard stick to substitute organic solvents for UAE of curcuminoids from C. domestica. At maximum set energy, the MAE optimum extraction parameters were particle size of 0.30-0.60 mm, extraction time of 3 min, extraction solvent volume of 10 mL and extraction temperature of 60°C with RRs of 92.48-99.44%, 90.58-97.43% and 90.03-96.07% for C, DMC and BDMC, respectively. Both UAE and MAE applications showed remarkable improvements in terms of extraction time, solvent consumption, extraction yield and the quality of extracts compared to conventional cold solvent extractions method. However, as compared to UAE, the optimized MAE application was better in term of quantity of curcuminoids. MAE is also simpler, faster, more efficient approach and allows the possibility of simultaneous multiple extractions. The inclusion complex formed using Mß-CD with the application of MAE was more stable than that with UAE based on the stability constant (KC) values of 213.08 M-1 and 515.19 M-1, for UAE and MAE, respectively. Results from characterization of the inclusion complex with scanning electron microscope showed that co-precipitation method was best for UAE while all of the mixing methods can be used for the inclusion complexation with MAE application. The kneading and co-precipitation methods were found to be the best for the inclusion complexation between turmeric rhizome oleoresins and Mß- CD in UAE, while all of the mixing methods were found to be suitable for inclusion complexation of turmeric rhizome oleoresins with Mß-CD in MAE as indicated by Fourier transform infrared spectroscopy 2014-05 Thesis http://eprints.utm.my/id/eprint/77890/ http://eprints.utm.my/id/eprint/77890/1/BintaHadiJumePFS2014.pdf application/pdf en public http://dms.library.utm.my:8080/vital/access/manager/Repository/vital:98372 phd doctoral Universiti Teknologi Malaysia, Faculty of Science Faculty of Science
institution	Universiti Teknologi Malaysia
collection	UTM Institutional Repository
language	English
topic	QD Chemistry
spellingShingle	QD Chemistry Jume, Binta Hadi Ultrasonic- and microwave-assisted extraction of curcuminoids and cyclodextrin complexes of curcumin from C. domestica Val.
description	This study investigates the isolation of curcuminoids from Curcuma domestica Val. using ultrasonic-assisted extraction (UAE), microwave-assisted extraction (MAE) compared with conventional cold solvent extraction method and the use of inclusion complexation of curcumin with methyl-?-cyclodextrin (Mß-CD) for improving their solubility. The extractions were optimized by determining the content of three curcuminoid markers, namely curcumin (C), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC). The extraction efficiencies were compared in terms of extraction time, sample through-put and solvent consumption. The optimized parameters for UAE of curcuminoids were extraction amplitude of 100, particle size of 0.30-0.60 mm, extraction time of 20 min, extraction solvent volume of 10 mL and extraction temperature of 60°C. Meanwhile, the relative recoveries (RRs) for aqueous extraction were in the range of 91.59-98.99%, 89.79- 94.95% and 89.33-94.77% for C, DMC and BDMC, respectively. Although UAE using methanol resulted in a slightly higher extraction yield and shorter extraction time compared to those using water, both methods showed similar pattern of results. Despite these, water is cost effective, safe and environmentally friendly. These advantages of aqueous solvent can be used as a yard stick to substitute organic solvents for UAE of curcuminoids from C. domestica. At maximum set energy, the MAE optimum extraction parameters were particle size of 0.30-0.60 mm, extraction time of 3 min, extraction solvent volume of 10 mL and extraction temperature of 60°C with RRs of 92.48-99.44%, 90.58-97.43% and 90.03-96.07% for C, DMC and BDMC, respectively. Both UAE and MAE applications showed remarkable improvements in terms of extraction time, solvent consumption, extraction yield and the quality of extracts compared to conventional cold solvent extractions method. However, as compared to UAE, the optimized MAE application was better in term of quantity of curcuminoids. MAE is also simpler, faster, more efficient approach and allows the possibility of simultaneous multiple extractions. The inclusion complex formed using Mß-CD with the application of MAE was more stable than that with UAE based on the stability constant (KC) values of 213.08 M-1 and 515.19 M-1, for UAE and MAE, respectively. Results from characterization of the inclusion complex with scanning electron microscope showed that co-precipitation method was best for UAE while all of the mixing methods can be used for the inclusion complexation with MAE application. The kneading and co-precipitation methods were found to be the best for the inclusion complexation between turmeric rhizome oleoresins and Mß- CD in UAE, while all of the mixing methods were found to be suitable for inclusion complexation of turmeric rhizome oleoresins with Mß-CD in MAE as indicated by Fourier transform infrared spectroscopy
format	Thesis
qualification_name	Doctor of Philosophy (PhD.)
qualification_level	Doctorate
author	Jume, Binta Hadi
author_facet	Jume, Binta Hadi
author_sort	Jume, Binta Hadi
title	Ultrasonic- and microwave-assisted extraction of curcuminoids and cyclodextrin complexes of curcumin from C. domestica Val.
title_short	Ultrasonic- and microwave-assisted extraction of curcuminoids and cyclodextrin complexes of curcumin from C. domestica Val.
title_full	Ultrasonic- and microwave-assisted extraction of curcuminoids and cyclodextrin complexes of curcumin from C. domestica Val.
title_fullStr	Ultrasonic- and microwave-assisted extraction of curcuminoids and cyclodextrin complexes of curcumin from C. domestica Val.
title_full_unstemmed	Ultrasonic- and microwave-assisted extraction of curcuminoids and cyclodextrin complexes of curcumin from C. domestica Val.
title_sort	ultrasonic- and microwave-assisted extraction of curcuminoids and cyclodextrin complexes of curcumin from c. domestica val.
granting_institution	Universiti Teknologi Malaysia, Faculty of Science
granting_department	Faculty of Science
publishDate	2014
url	http://eprints.utm.my/id/eprint/77890/1/BintaHadiJumePFS2014.pdf
_version_	1747817856150536192

Ultrasonic- and microwave-assisted extraction of curcuminoids and cyclodextrin complexes of curcumin from C. domestica Val.

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